Effects of Paediatric Post-COVID-19 Condition on Physical Function and Daily Functioning : A Cross-Sectional Study
Goicoechea Calvo, Aroia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Coll-Fernandez, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navarro Expósito, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Colomer Giralt, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gonzalez-Aumatell, Alba (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Méndez Hernández, Maria (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Carreras-Abad, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pallares Fontanet, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tebé, Cristian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Dura Mata, María José (Universitat Autònoma de Barcelona. Departament de Medicina)
Rodrigo Gonzalo de Líria, Carlos (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)

Data:	2025
Resum:	Background/Objectives: Lack of objective evidence exists regarding changes in physical function and impact on daily functioning in paediatric post-COVID-19 condition (PPCC). This study aimed to assess exercise capacity, fatigue, and peripheral and respiratory muscle strength in PPCC patients compared with healthy controls. Additionally, the impact of PPCC on domains of daily life was evaluated. Methods: A cross-sectional study was performed. Study variables: exercise capacity (6 min walk test, 6MWT), inspiratory muscle strength (maximal inspiratory pressure, PImax), handgrip strength (handheld dynamometer, HHD), quadriceps femoris muscle thickness (QF MT), rectus femoris muscle thickness (RF MT), rectus femoris cross-sectional area (RF CSA), rectus femoris echo-intensity (RF EI), fatigue (Paediatric Functional Assessment of Chronic Illness Therapy-Fatigue, pedsFACIT-F), and physical activity (Assessment of Physical Activity Levels Questionnaire, APALQ). Results: A total of 115 PPCC patients and 227 healthy controls were included. The PPCC group had lower 6MWT (509. 00 ± 86. 12, p < 0. 001), PImax (68. 71 ± 26. 23, p < 0. 001), HHD (82. 84 ± 29. 09, p < 0. 001), APALQ (7. 94 ± 3. 14, p < 0. 001), pedsFACIT-F (24. 51 ± 11. 01, p < 0. 001), QF MT mid-thigh (33. 21 ± 7. 99, p = 0. 011), and higher RF EI (p < 0. 001) vs. controls. Only 37. 63% of the PPCC group resumed previous sports, 43. 48% were unable to attend school full-time and 28. 7% could not participate in after-school activities. Conclusions: Paediatric post-COVID-19 condition patients exhibited significant impairments in terms of physical function, with a high impact on daily functioning. This knowledge is necessary to provide targeted therapeutic interventions.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	paediatric post-COVID-19 condition ; long COVID ; Children ; Exercise capacity ; Physical activity ; Fatigue ; Young people ; Adolescents
Publicat a:	Children, Vol. 12, Num. 9 (September 2025) , art. 1216, ISSN 2227-9067

DOI: 10.3390/children12091216
PMID: 41007081

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