Addressing Heterogeneity in Binge Eating Disorder : A Cluster Analysis Approach Based on Age of Onset, Clinical and Psychopathological Features
Camacho-Barcia, Lucía (Hospital Universitari de Bellvitge. Servei de Psicologia Clínica)
Sánchez-Salido, Lia T (Universitat de Barcelona. Departament d'Infermeria Fonamental i Clínica)
Jiménez-del Toro, Jessica (Hospital Universitari de Bellvitge. Servei de Psicologia Clínica)
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Sánchez, Isabel (Universitat de Barcelona. Departament de Ciències Clíniques)
Supit, Kim (Universiteit van Amsterdam. Department of Neurobiology)
Micali, Nadia (Great Ormond Street Institute of Child Health (Regne Unit))
Giel, Katrin E (University of Tübingen. Department of Psychosomatic Medicine)
Jiménez-Murcia, Susana (Universitat de Barcelona. Departament de Ciències Clíniques)
Zipfel, Stephan (University of Tübingen. Centre of Excellence for Eating Disorders (KOMET))
Fernández Aranda, Fernando (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)

Data:	2025
Descripció:	13 pàg.
Resum:	This study investigates clinical heterogeneity in patients with binge eating disorder (BED) and its association with treatment outcomes. A two-step cluster analysis was conducted on a clinical sample of 196 BED patients, using an agglomerative hierarchical procedure based on both categorical and quantitative measures-psychopathological symptoms, personality traits, emotional dysregulation, body composition, and food addiction. A subsequent comparison between clusters assessed therapy outcomes. Two distinct clusters emerged: C1 (n = 77) and C2 (n = 119). C2 patients exhibited a more dysfunctional profile, marked by more frequent binge episodes, higher eating psychopathology, greater emotion regulation difficulties, higher impulsivity levels, worse psychopathological state, higher food addiction levels, and personality traits reflecting greater harm avoidance and lower self-directedness and cooperativeness. While clusters did not differ by age, C2 had earlier age of onset and longer duration of the disorder. In contrast, C1 showed a more functional profile, later age of onset, lower total body fat mass, and better treatment outcomes. These findings highlight heterogeneity in BED, particularly regarding age of onset and associated clinical features, which may influence treatment response. The results suggest the need for distinct treatment strategies and more personalised therapeutic approaches tailored to patient subtypes.
Ajuts:	European Commission 101080219 Instituto de Salud Carlos III FORT23/00032 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00824
Nota:	Altres ajuts: We also thank CERCA Programme/Generalitat de Catalunya for institutional support. FFA and RG were supported by The Catalan Institution for Research and Advanced Studies (ICREA Academia Program). LCB was supported by Sara Borrell fellowship -CD22/00171- Instituto de Salud Carlos III (ISCIII) and co-founded by the European Union.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	European eating disorders review, 2025 , ISSN 1099-0968

DOI: 10.1002/erv.70034
PMID: 41045041

13 p, 698.8 KB

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