Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina
Jenssen, Marte (UiT-The Arctic University of Norway)
Kristoffersen, Venke (UiT-The Arctic University of Norway)
Motiram-Corral, Kumar (Universitat Autònoma de Barcelona)
Isaksson, Johan (UiT-The Arctic University of Norway)
Rämä, Teppo (UiT-The Arctic University of Norway)
Andersen, Jeanette H. (UiT-The Arctic University of Norway)
Hansen, Espen H. (UiT-The Arctic University of Norway)
Hansen, Kine Østnes (UiT-The Arctic University of Norway)

Data:	2021
Descripció:	8
Resum:	As part of our search for bioactive metabolites from understudied marine microorganisms, the new chlorinated metabolite chlovalicin B (1) was isolated from liquid cultures of the marine basidiomycete Digitatispora marina, which was collected and isolated from driftwood found at Vannøya, Norway. The structure of the novel compound was elucidated by spectroscopic methods including 1D and 2D NMR and analysis of HRMS data, revealing that 1 shares its molecular scaffold with a previously isolated compound, chlovalicin. This represents the first compound isolated from the Digitatispora genus, and the first reported fumagillin/ovalicin-like compound isolated from Basidiomycota. Compound 1 was evaluated for antibacterial activities against a panel of five bacteria, its ability to inhibit bacterial biofilm formation, for antifungal activity against Candida albicans, and for cytotoxic activities against malignant and non-malignant human cell lines. Compound 1 displayed weak cytotoxic activity against the human melanoma cell line A2058 (~50% survival at 50 µM). No activity was detected against biofilm formation or C. albicans at 50 µM, or against bacterial growth at 100 µM nor against the production of cytokines by the human acute monocytic leukemia cell line THP-1 at 50 µM.
Ajuts:	European Commission 690944
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Digitatispora marina ; Marine fungus sensu stricto ; Basidiomycota ; Bioprospecting ; Chlorinated secondary metabolite ; Natural products
Publicat a:	Molecules, Vol. 26, Num. 24 (December 2021) , art. 7560, ISSN 1420-3049

DOI: 10.3390/molecules26247560
PMID: 34946641

8 p, 713.0 KB

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