Impact of gastrointestinal symptoms and psychological distress on quality of life in systemic sclerosis : a cross-sectional study
Alcalá González, Luis Gerardo (Hospital Universitari Vall d'Hebron)
Guillén-Del-Castillo, Alfredo (Hospital Universitari Vall d'Hebron)
Aguilar, Ariadna (Hospital Universitari Vall d'Hebron)
Barber Caselles, Claudia (Hospital Universitari Vall d'Hebron)
Codina, Claudia (Hospital Universitari Vall d'Hebron)
Marín García, Antonio (Hospital Universitari Vall d'Hebron)
Malagelada Prats, Carolina (Universitat Autònoma de Barcelona)
Simeón-Aznar, Carmen Pilar (Hospital Universitari Vall d'Hebron)

Data:	2024
Resum:	Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by microvascular damage and fibrosis. Mortality in patients with SSc has significantly decreased. Consequently, patients with SSc have longer life expectancy, and health-related quality of life (HrQoL) has become more relevant in the comprehensive management of the disease. To evaluate the impact between gastrointestinal (GI) symptom burden and psychological well-being on HrQoL in patients with SSc. Nested cross-sectional study conducted between January and July 2022. A single-centre cohort of 166 patients with SSc, including 103 (55%) with limited cutaneous SSc, 43 (24%) with diffuse SSc and 37 (21%) with sine-sclerosis SSc. GI symptom burden was assessed using the University of California Los Angeles Scleroderma Clinical Trial Consortium gastrointestinal tract 2. 0 (UCLA SCTC GIT 2. 0) questionnaire, psychological well-being was measured with the Hospital Anxiety and Depression Scale (HADS), and HrQoL was evaluated using the Short Form 36 (SF-36) questionnaire. Demographic, clinical and immunological data were collected from a prospectively maintained database. Patients with moderate to severe GI symptoms (UCLA SCTC GIT 2. 0 score.
Ajuts:	Instituto de Salud Carlos III PI22/01804
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Quality of Life ; Psychological Stress ; Motility disorders
Publicat a:	BMJ open, Vol. 14 (november 2024) , ISSN 2044-6055

DOI: 10.1136/bmjopen-2024-089725
PMID: 39609018

8 p, 1.3 MB

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