HDL-Cholesterol and Triglycerides Dynamics : Essential Players in Metabolic Syndrome
Alcover, Sebastian (Institut de Recerca Sant Pau)
Ramos-Regalado, Lisaidy (Institut de Recerca Sant Pau)
Girón Martínez, Gabriela Obdulia (Institut de Recerca Sant Pau)
Muñoz-García, N. (Universitat de Barcelona)
Vilahur, Gemma (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	Metabolic syndrome (MetS) is a complex cluster of interrelated metabolic disorders that significantly elevate the risk of cardiovascular disease, making it a pressing public health concern worldwide. Among the key features of MetS, dyslipidemia-characterized by altered levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)-plays a crucial role in the disorder's progression. This review aims to elucidate the intricate interplay between HDL-C and TG within the context of lipid metabolism and cardiovascular health, while also addressing the detrimental impact of various cardiovascular risk factors and associated comorbidities. The dynamics of HDL-C and TG are explored, highlighting their reciprocal relationship and respective contributions to the pathophysiology of MetS. Elevated levels of TGs are consistently associated with reduced concentrations of HDL-C, resulting in a lipid profile that promotes the development of vascular disease. Specifically, as TG levels rise, the protective cardiovascular effects of HDL-C are diminished, leading to the increased accumulation of pro-atherogenic TG-rich lipoproteins and low-density lipoprotein particles within the vascular wall, contributing to the progression of atheromas, which can ultimately result in significant ischemic cardiovascular events. Ultimately, this paper underscores the significance of HDL and TG as essential targets for therapeutic intervention, emphasizing their potential in effectively managing MetS and reducing cardiovascular risk.
Ajuts:	Agencia Estatal de Investigación PID2021-128891OB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1480
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	HDL ; Antioxidant activity ; Atherosclerosis ; Cardiovascular disease ; Insulin resistance ; Lipid metabolism ; Metabolic syndrome ; Reverse cholesterol transport ; Triglycerides
Publicat a:	Antioxidants, Vol. 14 Núm. 4 (april 2025) , p. 434, ISSN 2076-3921

DOI: 10.3390/antiox14040434
PMID: 40298782

27 p, 2.5 MB

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