Volitional learning promotes theta phase coding in the human hippocampus
Pacheco Estefan, Daniel (Ruhr-Universität Bochum. Abteilung für Neuropsychologie)
Zucca, Riccardo (Institut Hospital del Mar d'Investigacions Mèdiques)
Arsiwalla, Xerxes D. (Institute for Bioengineering of Catalonia (IBEC). Universitat Pompeu Fabra (UPF))
Principe, Alessandro (Institut Hospital del Mar d'Investigacions Mèdiques)
Zhang, Hui (Ruhr-Universität Bochum)
Rocamora Zúñiga, Rodrigo Alberto (Institut Hospital del Mar d'Investigacions Mèdiques)
Axmacher, Nikolai (Ruhr-Universität Bochum)
Verschure, Paul F. M. J. (Institute for Bioengineering of Catalonia (IBEC). Universitat Pompeu Fabra (UPF). ICREA, Catalan Institution for Research and Advanced Studies)

Data:	2021
Resum:	Electrophysiological studies in rodents show that active navigation enhances hippocampal theta oscillations (4-12 Hz), providing a temporal framework for stimulus-related neural codes. Here we show that active learning promotes a similar phase coding regime in humans, although in a lower frequency range (3-8 Hz). We analyzed intracranial electroencephalography (iEEG) from epilepsy patients who studied images under either volitional or passive learning conditions. Active learning increased memory performance and hippocampal theta oscillations and promoted a more accurate reactivation of stimulus-specific information during memory retrieval. Representational signals were clustered to opposite phases of the theta cycle during encoding and retrieval. Critically, during active but not passive learning, the temporal structure of intracycle reactivations in theta reflected the semantic similarity of stimuli, segregating conceptually similar items into more distant theta phases. Taken together, these results demonstrate a multilayered mechanism by which active learning improves memory via a phylogenetically old phase coding scheme.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	active learning ; intracranial EEG ; theta oscillations ; neural phase coding ; hippocampus
Publicat a:	Proceedings of the National Academy of Sciences of the United States of America, Vol. 118 Núm. 10 (2021) , ISSN 1091-6490

DOI: 10.1073/pnas.2021238118
PMID: 33674388

12 p, 2.1 MB

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