The history of Down syndrome-associated Alzheimer's disease; past, present, and future
Maure Blesa, Lucia (Institut de Recerca Sant Pau)
Carmona Iragui, Maria (Institut de Recerca Sant Pau)
Lott, I. (Irvine. School of Medicine)
Head, Elizabeth (University of California. Irvine)
Wisniewski, Thomas M. (New York University Grossman School of Medicine)
Rafii, M.S. (University of Southern California)
Espinosa, J. (University of Colorado Anschutz Medical Campus)
Flórez, J. (University of Cantabria)
Mobley, W.C. (University of California San Diego)
Holland, A. (University of Cambridge)
Strydom, A. (King's College London)
Zaman, Shahid (University of Cambridge)
Fortea, Juan (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2025
Resum:	The landscape of Down syndrome-associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observations to the elucidation of complex genetic and molecular mechanisms. This perspective article chronicles key milestones and breakthroughs, paying homage to the pioneering scientists and advancements that have shaped the field. A thorough review of historical and contemporary literature offers a comprehensive narrative, highlighting the evolution of knowledge surrounding DSAD, from early recognition to the characterization of clinical presentation and natural history. The unique challenges and ethical considerations associated with DSAD populations are also examined, underscoring the importance of tailoring research and clinical approaches. By reflecting on the field's trajectory, this work celebrates past achievements while emphasizing the critical need for sustained research efforts. As part of a special issue, this article provides a foundation for appreciating the challenges and opportunities that lie ahead in advancing DSAD understanding and care. Highlights: This article provides a comprehensive overview of Down syndrome-associated Alzheimer's disease (DSAD) history, from early descriptions to its recognition as a genetic form of AD. It reflects on historical challenges faced by individuals with intellectual disabilities in achieving inclusion in scientific research. This historical perspective highlights the critical contributions of individuals with DS in advancing understanding of AD natural history. It explores pivotal milestones and efforts that have driven progress in DSAD research. Finally, it provides context to understand challenges and opportunities in DSAD research and its future directions.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Down syndrome ; Down syndrome-associated Alzheimer's disease ; amyloid ; clinical trials ; historical perspective
Publicat a:	Alzheimer's & dementia, Vol. 21 Núm. 6 (june 2025) , p. e70158, ISSN 1552-5279

DOI: 10.1002/alz.70158
PMID: 40469048

12 p, 1012.9 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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