Treatment Algorithms for Inflammatory Myopathies in Adults : from Guidelines to Clinical Practice
Selva O'Callaghan, Albert (Hospital Universitari Vall d'Hebron)
Trallero Araguás, Ernesto (Hospital Universitari Vall d'Hebron)
Gil Vila, Albert (Hospital Universitari Vall d'Hebron)
Matas-Garcia, Ana (Hospital Clínic i Provincial de Barcelona)
Edo-Fernandez, Clara (Hospital Universitari Vall d'Hebron)
Milisenda, José César (Hospital Clínic i Provincial de Barcelona)
Pinal Fernandez, Iago (Johns Hopkins University School of Medicine)

Data:	2025
Resum:	Purpose of Review Inflammatory myopathies are a heterogeneous group of systemic autoimmune disorders with highly variable clinical presentations. The limited number of clinical trials has hindered the development of strong evidence-based management strategies. Therefore, there is a pressing need for consensus-driven treatment guidelines tailored to the various clinical and immunological phenotypes. This review combines existing published guidelines with the authors' clinical experience to provide a comprehensive, pragmatic approach to management. Recent Findings A comparative review of existing treatment guidelines was recently published, revealing significant heterogeneity in therapeutic approaches and recommendations. This observation is consistent with our own experience during a multidisciplinary meeting, primarily involving internal medicine specialists and rheumatologists. Furthermore, recent clinical trials and observational studies investigating novel therapies offer promising prospects that could influence future clinical decision-making. Summary Although establishing a unified therapeutic algorithm remains challenging, this review aims to translate current knowledge into clinical practice by integrating existing guidelines, our own clinical experience, and the most recent evidence published on the topic.
Ajuts:	Instituto de Salud Carlos III PI22/00708
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; Versió publicada
Matèria:	Inflammatory myopathy ; Myositis ; Dermatomyositis ; Antisynthetase syndrome ; Immune-mediated necrotizing myopathy ; Myositis guidelines ; Myositis treating algorithm ; Myositis clinical practice
Publicat a:	Current treatment options in rheumatology, Vol. 11 (2025) , art. 21, ISSN 2198-6002

DOI: 10.1007/s40674-025-00239-5

16 p, 2.5 MB

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