ASPHIRE : AsseSsing the Pulmonary Hazards and molecular mechanIsms of Nanoplastics from TyRe Wear Emissions
Egea, Raquel (Universitat Autònoma de Barcelona)
Hernández Bonilla, Alba
Rubio Lorente, Laura

Publicación:	Universitat Autònoma de Barcelona, 2025
Resumen:	The ASPHIRE project aims to advance the evidence base on the pulmonary toxicity of tyre-wear nanoplastics (TW-NPLs) by elucidating the cellular and molecular mechanisms underlying adverse outcomes, thereby informing effective mitigation strategies and regulatory measures to safeguard public health. Purpose of the data: The data collected will support the following project objectives: 1. Generation of TW-NPL test materials. Characterise various TW-NPLs physicochemical properties to understand their properties and cell internalisation behaviour. 2. Definition of the cellular and molecular processes altered by long-term exposure to TW-NPLs. Analyse the behaviour and fate of TW-NPLs using New Advanced Methodologies including the assessment of key biological effects, the analysis of omic alterations and functional and molecular assays to validate findings. 3. Establishment of causal relationships and characterisation fo the molecular mechanisms. Integration of internal and external evidence using a weight-of-evidence approach and organization within an AOP framekork. Data collection: 1. Nanoplastics Characterisation, 2. Nanoplastics Internalisation. 3. Advanced ALI Calu-3 model. 4. Key biological effects. 5. Omic alterations. 6. Integration of internal and external evidence. 7. AOP framework. Most of the data will be in ASCII (American Standard Code for Information Interchange) files, e. g. comma-separated variable (CSV) format, which can be imported into rich text files for word processing or spreadsheets. Where specialist software is used, information on free readers will be provided. Data will be produced in the following formats: Images: jpeg, odg, pdf, png, tiff, pttx; Tables: xlsx, csv; Text: docx, pdf, txt, fastq. The estimated size of the raw data may reach up to 1TB.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Pla de gestió de dades

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