Artículos

Artículos Encontrados 521 registros  anterior11 - 20siguientefinal  ir al registro: La búsqueda tardó 0.00 segundos. 
11.
20 p, 2.2 MB Role of muscle IL-6 in gender-specific metabolism in mice / Molinero Egea, María Amalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fernandez-Perez, Antonio (Universidad Autonoma de Madrid. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades metabólicas asociadas CIBERDEM) ; Mogas Barcons, Aina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giralt Carbonell, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Comes Orpinell, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fernandez Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Vallejo, Mario (Universidad Autonoma de Madrid (CSIC-UAM). Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades metabólicas asociadas CIBERDEM.) ; Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature cycle during the light phase) and energy intake (response to fast/ refeeding). [...]
2017 - 10.1371/journal.pone.0173675
PLoS ONE, Vol. 12, Núm. 3 (March 2017) , art. e173675  
12.
18 p, 288.5 KB Translational research opportunities regarding homologous recombination in ovarian cancer / Romeo Marín, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pardo, J.C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Román, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Solé, Francesc (Institut Germants Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and rucaparib are already commercialized). [...]
2018 - 10.3390/ijms19103249
International Journal of Molecular Sciences, Vol. 19 Núm. 10 (19 2018) , p. 3249  
13.
11 p, 1.1 MB Immune-mediated inflammatory diseases differently affect IGRAs' accuracy for latent tuberculosis infection diagnosis in clinical practice / Latorre,Irene (Institut Germans Trias i Pujol. Servei de Microbiologia) ; Mínguez, Sonia (Institut Germans Trias i Pujol. Servei de Reumatologia) ; Carrascosa, José-Manuel (Institut Germans Trias i Pujol. Servei de Dermatologia) ; Naves, Juan (Institut Germans Trias i Pujol. Servei de Digestiu) ; Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Servei de Microbiologia) ; Muriel, Beatriz (Institut Germans Trias i Pujol. Servei de Microbiologia) ; Prat, Cristina (Institut Germans Trias i Pujol. Servei de Microbiologia) ; García-García, Esther (Institut Germans Trias i Pujol. Servei de Microbiologia) ; Casas, Irma (Institut Germans Trias i Pujol. Servei de Medicina Preventiva) ; Domènech, Eugeni (Institut Germans Trias i Pujol. Servei de Digestiu) ; Ferrándiz, Carlos (Institut Germans Trias i Pujol. Servei de Dermatologia) ; Mateo, Lourdes (Institut Germans Trias i Pujol. Servei de Reumatologia) ; Domínguez, Jose (Institut Germans Trias i Pujol. Servei de Microbiologia) ; Universitat Autònoma de Barcelona
Background. Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT. [...]
2017 - 10.1371/journal.pone.0189202
Plos one, Vol. 12 Núm. 12 (december 2017) , p. 1-11  
14.
12 p, 1.2 MB Epidemiological, clinical, diagnostic and economic features of an immigrant population of chronic schistosomiasis sufferers with long-term residence in a nonendemic country (North Metropolitan area of Barcelona, 2002-2016) / Roure, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Valerio, Lluís (Servei Atenció Primària, Santa Coloma de Gramenet) ; Pérez-Quílez, Olga (Servei Atenció Primària, Santa Coloma de Gramenet) ; Fernádez-Rivas, Gema (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez-Cuevas, Octavio (Servei Atenció Primària, Santa Coloma de Gramenet) ; Alcántara-Román, Albert (Servei Atenció Primària, Santa Coloma de Gramenet) ; Viasus, Diego (Hospital Universidad del Norte (Barranquilla)) ; Pedro-Botet, M. Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sabrià, Miquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Background. Schistosomiasis, one of the neglected tropical diseases (NTD) listed by the WHO, is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. [...]
2017 - 10.1371/journal.pone.0185245
Plos one, Vol. 12 Núm. 9 (september 2017) , p. 1-12  
15.
15 p, 2.0 MB Monitoring t-cell responses in translational studies: optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-specific responses / Brinke, Anja ten (Sanquin Research (Amsterdam)) ; Marek-Trzonkowska,Natalia (Medical University of Gdansk. Department of Family Medicine) ; Mansilla, Maria J. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Turksma, Annelies W. (Sanquin Research (Amsterdam)) ; Piekarska, Karolina (Medical University of Gdansk. Department of Family Medicine) ; Iwaszkiewicz-Grzes, Dorota (Medical University of Gdansk. Department of Clinical Immunology and Transplantology) ; Passerini, Laura (IRCCS San Raffaele Scientific Institute) ; Locafaro, Grazia (IRCCS San Raffaele Scientific Institute) ; Puñet Ortiz, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; van Ham, S. Marieke (Sanquin Research (Amsterdam)) ; Hernandez Fuentes, Maria P. (MRC Centre for Transplantation, King's College London) ; Martínez Cáceres, Eva M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gregori, Silvia (IRCCS San Raffaele Scientific Institute) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Adoptive therapy with regulatory T cells or tolerance-inducing antigen (Ag)- presenting cells is innovative and promising therapeutic approach to control undesired and harmful activation of the immune system, as observed in autoimmune diseases, solid organ and bone marrow transplantation. [...]
2017
Frontiers in immunology, Vol. 8 (december 2017) , p. 1-15  
16.
15 p, 5.9 MB Prenatal administration of Betamethasone causes changes in the T cell receptor repertoire influencing Development of autoimmunity / Gieras, Anna (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Gehbauer, Christina (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Engler, Jan Broder (Institute of Neuroimmunology and Multiple Sclerosis. Center for Molecular Neurobiology Hamburg) ; Diepenbruck, Ines (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Glau, Laura (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Joosse, Simon A. (University Medical Center Hamburg-Eppendorf. Department of Tumor Biology) ; Kersten, Nora (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Klinge, Stefanie (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Mittrücker, Hans-Willi (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Friese, Manuel A. (Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology Hamburg) ; Vives-Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Tolosa, Eva (University Medical Center Hamburg-Eppendorf. Department of Immunology) ; Universitat Autònoma de Barcelona
Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. [...]
2017 - 10.3389/fimmu.2017.01505
Frontiers in immunology, Vol. 8 (november 2017) , p. 1-15  
17.
11 p, 2.5 MB A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles / Suárez, Henar (Instituto de Investigación Sanitaria La Princesa) ; Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Reyes, Raquel (Centro de Biología Molecular Severo Ochoa) ; López-Martín, Soraya (Instituto de Investigación Sanitaria La Princesa) ; Rodríguez, María Josefa (Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas) ; Carrascosa, José L. (Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas) ; Cabañas, Carlos (Centro de Biología Molecular Severo Ochoa) ; Borràs, Francesc E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Yáñez-Mó, María (Instituto de Investigación Sanitaria La Princesa) ; Universitat Autònoma de Barcelona
Most experimental approaches commonly employed for the characterization and quantitation of EVs are time consuming, require of specialized instrumentation and often are rather inaccurate. To circumvent the caveats imposed by EV small size, we used general and specific membrane markers in bead assisted flow cytometry, to provide a semi-quantitative measure of EV content in a given sample. [...]
2017 - 10.1038/s41598-017-11249-2
Scientific reports, Vol. 7 (september 2017) , p. 1-11  
18.
12 p, 3.0 MB Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses / Manils, Joan (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Fischer, Heinz (Medical University of Vienna. Department of Dermatology) ; Climent, Joan (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Casas, Eduard (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; García-Martínez, Celia (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Bas, Jordi (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Sukseree, Supawadee (Medical University of Vienna. Department of Dermatology) ; Vavouri, Tanya (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Ciruela, Francisco (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; de Anta, Josep Maria (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Tschachler, Erwin (Medical University of Vienna. Department of Dermatology) ; Eckhart, Leopold (Medical University of Vienna. Department of Dermatology) ; Soler, Concepció (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Universitat Autònoma de Barcelona
The cornification of keratinocytes on the surface of skin and oral epithelia is associated with the degradation of nuclear DNA. The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifying keratinocytes. [...]
2017 - 10.1038/s41598-017-12308-4
Scientifics reports, Vol. 7 (september 2017) , p. 1-12  
19.
13 p, 3.4 MB Human Pancreatic ß Cell lncRNAs Control Cell-Specific Regulatory Networks / Akerman, Ildem (Institut d’Investigacions Biomèdiques August Pi I Sunyer) ; Tu, Zhidong (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ; Beucher, Anthony (Department of Medicine, Imperial College London) ; Rolando, Delphine M.Y. (Department of Medicine, Imperial College London) ; Sauty-Colace, Claire (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière) ; Benazra, Marion (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière) ; Nakic, Nikolina (Department of Medicine, Imperial College London) ; Yang, Jialiang (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ; Wang, Huan (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ; Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Moran, Ignasi (Department of Medicine, Imperial College London) ; Garcia Hurtado, Javier (Institut d’Investigacions Biomèdiques August Pi I Sunyer) ; Castro, Natalia (Institut d’Investigacions Biomèdiques August Pi I Sunyer) ; Gonzalez Franco, Roser (Department of Medicine, Imperial College London) ; Stewart, Andrew F. (Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai) ; Bonner, Caroline (European Genomic Institute for Diabetes) ; Piemonti, Lorenzo (Diabetes Research Institute (HSR-DRI), San Raffaele Scientific Institute) ; Berney, Thierry (Cell Isolation and Transplantation Center, University of Geneva,) ; Groop, Leif (Department of Clinical Sciences, Lund University Diabetes Centre) ; Kerr-Conte, Julie (European Genomic Institute for Diabetes) ; Pattou, Francois (European Genomic Institute for Diabetes) ; Argmann, Carmen (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ; Schadt, Eric (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai) ; Ravassard, Phillipe (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière) ; Jorge Ferrer (Institut d’Investigacions Biomèdiques August Pi i Sunyer) ; Universitat Autònoma de Barcelona
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic ß cells. ß cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. [...]
2017 - 10.1016/j.cmet.2016.11.016
Cell metabolism, Vol. 25 (february 2017) , p. 400-411  
20.
10 p, 1.4 MB Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case- Control (MCC) Study / Gómez Acebo, Inés (CIBER Epidemiologia y Salud Pública) ; Dierssen Sotos, Trinidad (CIBER Epidemiologia y Salud Pública) ; Fernandez Navarro, Pablo (CIBER Epidemiologia y Salud Pública) ; Palazuelos, Camilo (Universidad de Cantabria) ; Moreno, Víctor (Institut Català d'Oncologia) ; Aragonés, Nuria (CIBER Epidemiologia y Salud Pública) ; Castaño Vinyals, Gemma (CIBER Epidemiologia y Salud Pública) ; Jiménez Monleón, Jose J. (CIBER Epidemiologia y Salud Pública) ; Ruiz Cerdá, Jose Luis (Hospital Universitario La Fe) ; Pérez Gómez, Beatriz (CIBER Epidemiologia y Salud Pública) ; Ruiz-Dominguez, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Alonso Molero, Jessica (Universidad de Cantabria) ; Pollán, Marina (CIBER Epidemiologia y Salud Pública) ; Kogevinas, Manolis (CIBER Epidemiologia y Salud Pública) ; Llorca, Javier (CIBER Epidemiologia y Salud Pública) ; Universitat Autònoma de Barcelona
Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. [...]
2017 - 10.1038/s41598-017-09386-9
Scientific reports, Vol. 7 Núm. 8994 (august 2017) , p. 1-10  

Artículos : Encontrados 521 registros   anterior11 - 20siguientefinal  ir al registro:
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