Articles

Articles 21 registres trobats  anterior11 - 20següent  anar al registre: La cerca s'ha fet en 0.00 segons. 
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None, 434.1 KB Network-centric medicine for peripheral nerve injury : treating the whole to boost endogenous mechanisms of neuroprotection and regeneration / Romeo-Guitart, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Peripheral nerve injuries caused by accidents may lead to paralysis, sensory disturbances, anaesthesia, and lack of autonomic functions. Functional recovery after disconnection of the motoneuronal soma from target tissue with proximal rupture of axons is determined by several factors: motoneuronal soma viability, proper axonal sprouting across inhibitory zones and elongation toward specific muscle, effective synapse contact rebuilding, and prevention of muscle atrophy. [...]
2019 - 10.4103/1673-5374.251187
Neural Regeneration Research, Vol. 14 (july 2019) , p. 1122-1128  
12.
20 p, 3.3 MB Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy / Romeo-Guitart, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Leiva-Rodríguez, Tatiana (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Complete restoring of functional connectivity between neurons or target tissue after traumatic lesions is still an unmet medical need. Using models of nerve axotomy and compression, we investigated the effect of autophagy induction by genetic and pharmacological manipulation on motor nerve regeneration. [...]
2019 - 10.3390/cells8111354
Cells, Vol. 8 Núm. 11 (2019) , p. 1-20  
13.
15 p, 1.2 MB GRP78 at the centre of the stage in cancer and neuroprotection / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. [...]
2017 - 10.3389/fnins.2017.00177
Frontiers in Neuroscience, Vol. 11, (May 2017) , p. 177  
14.
15 p, 11.4 MB Neuroprotective drug for nerve trauma revealed using artificial intelligence / Romeo-Guitart, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valls, Raquel (Anaxomics Biotech.) ; Leiva-Rodríguez, Tatiana (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; González-Pérez, Francisco (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Petegnief, Valerie (Institut de Recerca Biomèdica de Lleida) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Coma, Mireia (Anaxomics Biotech.) ; Mas, José Manuel (Anaxomics Biotech.) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Here we used a systems biology approach and artifcial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. [...]
2018 - 10.1038/s41598-018-19767-3
Scientific reports, Vol. 8 (2018) , art. 1879  
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12 p, 7.4 MB Boosted Regeneration and Reduced Denervated Muscle Atrophy by NeuroHeal in a Pre-clinical Model of Lumbar Root Avulsion with Delayed Reimplantation / Romeo-Guitart, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
The "gold standard" treatment of patients with spinal root injuries consists of delayed surgical reconnection of nerves. The sooner, the better, but problems such as injury-induced motor neuronal death and muscle atrophy due to long-term denervation mean that normal movement is not restored. [...]
2017 - 10.1038/s41598-017-11086-3
Scientific reports, Vol. 7 (2017) , art. 12028  
16.
13 p, 3.4 MB Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Isus, Laura (Institut de Recerca Biomèdica de Lleida) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Mancuso, Francesco M. (Vall d'Hebron Institut d'Oncologia) ; Borràs, Eva (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Sabidó, Eduard (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats)
Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. [...]
2015 - 10.1038/srep09185
Scientific reports, Vol. 5 (2015) , art. 9185  
17.
17 p, 352.4 KB Synaptic failure : focus in an integrative view of ALS / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (Universidad de Zaragoza) ; Vaz, Rita (Universidade de Lisboa. Faculdade de Farmácia) ; Osta, Rosario (Universidad de Zaragoza) ; Brites, Dora (Universidade de Lisboa. Faculdade de Farmácia) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
From early description by Charcot, the classification of the Amyotrophic Lateral Sclerosis (ALS) is evolving from a subtype of Motor Neuron (MN) Disease to be considered rather a multi-systemic, non-cell autonomous and complex neurodegenerative disease. [...]
2016 - 10.3233/BPL-140001
Brain plasticity, Vol. 1, issue 2 (2016) , p. 159-175  
18.
14 p, 11.1 MB Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (Universidad de Zaragoza) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sporadic and familiar amyotrophic lateral sclerosis (ALS) cases presented lower cholinergic activity than in healthy individuals in their still preserved spinal motoneurons (MNs) suggesting that cholinergic reduction might occur before MN death. [...]
2013 - 10.1002/brb3.104
Brain and behavior, Vol. 3, Núm. 2 (February 2013) , p. 145-158  
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8 p, 491.4 KB Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12 / Badiola Benito, Nahuai (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Penas Pérez, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Barneda Zahonero, Bruna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fadó, Rut (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sánchez Opazo, Guillem (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Comella i Carnicé, Joan Xavier, 1963- (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sabrià i Pau, Josefa (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Zhu, Chao (University of Gothenburg. Institute of Neuroscience and Physiology) ; Blomgren, K. (University of Gothenburg. Institute of Neuroscience and Physiology) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing events that are activated by ER stress after cerebral ischemia are incompletely understood. [...]
2011 - 10.1038/cddis.2011.31
Cell death and disease, Vol. 2 (April 2011) , art. e149  
20.
17 p, 5.8 MB Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems / Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mulet, Roger (Anaxomics Biotech) ; Pujol, Albert (Institut de Recerca Biomèdica de Lleida) ; Mas, José Manuel (Anaxomics Biotech) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Aloy, Patrick (Institut de Recerca Biomèdica de Lleida) ; Coma, Mireia (Anaxomics Biotech) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there is no effective treatment. One of the main difficulties in developing new therapies lies on the multiple events that contribute to motor neuron death in amyotrophic lateral sclerosis. [...]
2016 - 10.1371/journal.pone.0147626
PloS one, Vol. 11, Num. 1 (January 2016) , p. 1-17  

Articles : 21 registres trobats   anterior11 - 20següent  anar al registre:
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