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Articles 38 registres trobats  anterior11 - 20següentfinal  anar al registre: La cerca s'ha fet en 0.03 segons. 
11.
16 p, 1.0 MB The role of macroh2a histone variants in cancer / Hsu, Chen-Jen (Internal Medicine C. Greifswald University Medicine) ; Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Heidel, Florian H. (Leibniz Institute on Aging. Fritz-Lipmann Institute)
The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. [...]
2021 - 10.3390/cancers13123003
Cancers, Vol. 13 Núm. 12 (february 2021) , p. 3003  
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12.
12 p, 1.9 MB Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease / Watt, Stephen (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Vasquez, Louella (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Walter, Klaudia (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Mann, Alice L. (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Kundu, Kousik (School of Clinical Medicine. University of Cambridge) ; Chen, Lu (Sichuan University) ; Sims, Ying (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Ecker, Simone (UCL Cancer Institute) ; Burden, Frances (National Health Service Blood and Transplant) ; Farrow, Samantha (National Health Service Blood and Transplant) ; Farr, Ben (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Iotchkova, Valentina (University of Oxford) ; Elding, Heather (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Mead, Daniel (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Tardaguila, Manuel (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Ponstingl, Hannes (Human Genetics. Wellcome Sanger Institute. Genome Campus) ; Richardson, David (European Molecular Biology Laboratory. European Bioinformatics Institute) ; Datta, Avik (European Molecular Biology Laboratory. European Bioinformatics Institute) ; Flicek, Paul (European Molecular Biology Laboratory. European Bioinformatics Institute) ; Clarke, Laura (European Molecular Biology Laboratory. European Bioinformatics Institute) ; Downes, Kate (National Health Service Blood and Transplant) ; Pastinen, Tomi (Center for Pediatric Genomic Medicine. Children's Mercy) ; Fraser, Peter (Florida State University) ; Frontini, Mattia (University of Exeter Medical School) ; Javierre, B. M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Spivakov, Mikhail (Imperial College Faculty of Medicine) ; Soranzo, Nicole (University of Cambridge)
Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. [...]
2021 - 10.1038/s41467-021-22548-8
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 2298  
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13.
18 p, 1.1 MB The mutational landscape of myeloid leukaemia in down syndrome / de Castro, Carini Picardi Morais (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Cadefau, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cuartero, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Children with Down syndrome (DS) are particularly prone to haematopoietic disorders. Paediatric myeloid malignancies in DS occur at an unusually high frequency and generally follow a well-defined stepwise clinical evolution. [...]
2021 - 10.3390/cancers13164144
Cancers, Vol. 13 Núm. 16 (august 2021) , p. 4144  
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14.
25 p, 6.2 MB Poly(Adp-ribose) binding and macroh2a mediate recruitment and functions of kdm5a at dna lesions / Kumbhar, Ramhari (University of Texas at Austin) ; Sanchez, Anthony (University of Texas at Austin) ; Perren, Jullian (University of Texas at Austin) ; Gong, Fade (Baylor College of Medicine) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Medina, Frank (University of Texas at Austin) ; Devanathan, Sravan K. (University of Texas at Austin) ; Xhemalce, Blerta (University of Texas at Austin) ; Matouschek, Andreas (University of Texas at Austin) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buck-Koehntop, Bethany A. (University of Utah) ; Miller, Kyle M. (University of Texas at Austin) ; Universitat Autònoma de Barcelona
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. [...]
2021 - 10.1083/jcb.202006149
The journal of cell biology, Vol. 220 Núm. 7 (2021) , p. e202006149  
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15.
15 p, 5.0 MB 3D chromatin remodelling in the germ line modulates genome evolutionary plasticity / Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Burden, Frances (University of Kent. School of Bioscience) ; Doddamani, Dadakhalandar (University of Kent. School of Bioscience) ; Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Leach, Emma (University of Kent. School of Bioscience) ; Marín-García, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gubern Burset, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Vara González, Covadonga (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Paytuví-Gallart, Andreu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ellis, Peter J. I. (University of Kent. School of Bioscience) ; Farré, Marta (University of Kent. School of Bioscience) ; Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chromosome folding has profound impacts on gene regulation, whose evolutionary consequences are far from being understood. Here we explore the relationship between 3D chromatin remodelling in mouse germ cells and evolutionary changes in genome structure. [...]
2022 - 10.1038/s41467-022-30296-6
Nature communications, Vol. 13 (May 2022) , art. 2608  
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16.
13 p, 1.6 MB MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma / Vella, Serena (Ospedale Pediatrico Bambino Gesù) ; Pomella, Silvia (Istituto Dermopatico dell'Immacolata) ; Leoncini, Pier Paolo (Ospedale Pediatrico Bambino Gesù) ; Colletti, Marta (Ospedale Pediatrico Bambino Gesù) ; Conti, Beatrice (Ospedale Pediatrico Bambino Gesù) ; Marquez, Victor E. (Frederick National Laboratory for Cancer Research) ; Strillacci, Antonio (University of Bologna) ; Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gallego, Soledad (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Milano, Giuseppe M. (Ospedale Pediatrico Bambino Gesù) ; Capogrossi, Maurizio C. (Istituto Dermopatico dell'Immacolata) ; Bertaina, Alice (Ospedale Pediatrico Bambino Gesù) ; Ciarapica, Roberta (Istituto Dermopatico dell'Immacolata) ; Rota, Rossella (Laboratory of Angiogenesis, Ospedale Pediatrico Bambino Gesù) ; Universitat Autònoma de Barcelona
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 histone H3 methyltransferase that regulates the balance between cell proliferation and differentiation by epigenetically silencing muscle-specific genes. [...]
2015 - 10.1186/s13148-015-0107-z
Clinical Epigenetics, Vol. 7 (august 2015)  
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17.
23 p, 4.4 MB Histone H1 Post-Translational Modifications : Update and Future Perspectives / Andrés Nieto, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; García-Gomis, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ponte Marull, Immaculada (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Suau, Pedro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Roque Córdova, Alicia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes. [...]
2020 - 10.3390/ijms21165941
International journal of molecular sciences, Vol. 21, Num. 16 (August 2020) , art. 5941  
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18.
14 p, 542.4 KB Chromatin dynamics and transcriptional control of circadian rhythms in arabidopsis / Marić, Aida (Centre de Recerca en Agrigenòmica) ; Mas, Paloma (Centre de Recerca en Agrigenòmica)
Circadian rhythms pervade nearly all aspects of plant growth, physiology, and development. Generation of the rhythms relies on an endogenous timing system or circadian clock that generates 24-hour oscillations in multiple rhythmic outputs. [...]
2020 - 10.3390/genes11101170
Genes, Vol. 11, Núm. 10 (October 2020) , art. 1170  
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19.
14 p, 2.0 MB Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation / Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bywater, M. J. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Sanij, E. (Department of Pathology. University of Melbourne) ; Cameron, D. P. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Schierding, W. (Liggins Institute. The University of Auckland) ; Brajanovski, N. (Cancer Research Division. Peter MacCallum Cancer Centre) ; Son, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Sornkom, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Hein, N. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ; Evers, M. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ; Pearson, R. B. (Department of Biochemistry and Molecular Biology. University of Melbourne) ; McArthur, G. A. (St Vincent's Hospital (Sydney)) ; Ganley, A. R. D. (School of Biological Sciences. The University of Auckland) ; O'Sullivan, J. M. (Liggins Institute. The University of Auckland) ; Hannan, R. D. (School of Biomedical Sciences. University of Queensland) ; Poortinga, G. (St Vincent's Hospital (Sydney)) ; Universitat Autònoma de Barcelona
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. [...]
2019 - 10.1038/s42003-019-0284-y
Communications Biology, Vol. 2 Núm. 1 (january 2019) , p. 39  
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20.
16 p, 2.3 MB SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina / Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Simonet, N. G. (Institut d'Investigació Biomèdica de Bellvitge) ; Chahar, S. (Montpellier Institute of Molecular Genetics (IGMM). CNRS. University of Montpellier) ; Kane-Goldsmith, N. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Newkirk, S. J. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ; Lee, S. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ; Xing, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Verzi, M. P. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; An, W. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ; Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Tischfield, J. A. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Serrano, L. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Universitat Autònoma de Barcelona
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. [...]
2019 - 10.1093/nar/gkz519
Nucleic acids research, Vol. 47 Núm. 15 (january 2019) , p. 7870-7885  
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