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21.
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18 p, 1.7 MB |
Addition of Immune Checkpoint Inhibitors to Chemotherapy vs Chemotherapy Alone as First-Line Treatment in Extensive-Stage Small-Cell Lung Carcinoma : A Systematic Review and Meta-Analysis
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Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
González-Cao, María (Hospital Dexeus) ;
Domine, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
de Castro, Javier (Hospital Universitario La Paz (Madrid)) ;
Cobo, Manuel (Instituto de Investigación Biomédica de Málaga) ;
Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Navarro, Alejandro (Vall d'Hebron Institut d'Oncologia) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Trigo, José Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Mosquera, Joaquín (Complejo Hospitalario Universitario de A Coruña) ;
Crama, Leonardo (Medical Department Roche) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Introduction: The addition of immune checkpoint inhibitors (ICIs) to conventional chemotherapy (CT) as first-line treatment improves survival in extensive-stage small-cell lung cancer (ES-SCLC). The aim of this meta-analysis was to determine the relative efficacy of first-line ICIs compared with CT in patients with ES-SCLC. [...]
2022 -  10.1007/s40487-021-00182-0
Oncology and Therapy, Vol. 10 Núm. 1 (june 2022) , p. 167-184
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22.
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9 p, 430.4 KB |
Dupilumab Efficacy in Steroid-Dependent Severe Asthma by Baseline Oral Corticosteroid Dose
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Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Maspero, Jorge F (Fundación CIDEA) ;
Castro, Mario (University of Kansas School of Medicine) ;
Hanania, Nicola A. (Baylor College of Medicine) ;
Ford, Linda B (Asthma & Allergy Center) ;
Halpin, David M G (College of Medicine and Health) ;
Jackson, David J (King's College London) ;
Daizadeh, Nadia (Sanofi-Syntelabo) ;
Djandji, Michel (Sanofi-Syntelabo) ;
Mitchell, Colin P (Sanofi-Syntelabo) ;
Crikelair, Nora (Regeneron Pharmaceuticals. Inc) ;
Jacob-Nara, Juby A (Sanofi-Syntelabo) ;
Deniz, Yamo (Regeneron Pharmaceuticals. Inc) ;
Rowe, Paul J (Sanofi-Syntelabo) ;
Ortiz, Benjamin (Regeneron Pharmaceuticals. Inc) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4/-13, key and central drivers of type 2 inflammation in multiple diseases. In the phase 3 LIBERTY ASTHMA VENTURE (VENTURE) study (NCT02528214), dupilumab versus placebo reduced oral corticosteroid (OCS) dose and improved clinical outcomes in patients with OCS-dependent severe asthma. [...]
2022 - 10.1016/j.jaip.2022.03.020
The Journal of allergy and clinical immunology. In practice, Vol. 10 Núm. 7 (July 2022) , p. 1835-1843
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23.
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14 p, 2.8 MB |
Infection dynamics, transmission, and evolution after an outbreak of porcine reproductive and respiratory syndrome virus
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Clilvert, Hepzibar (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Martín-Valls, Gerard (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Li, Yanli (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Martín Castillo, Margarita (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Cortey, Martí (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Mateu de Antonio, Enrique María (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
The present study was aimed at describing the infection dynamics, transmission, and evolution of porcine reproductive and respiratory syndrome virus (PRRSV) after an outbreak in a 300-sow farrow-to-wean farm that was implementing a vaccination program. [...]
2023 - 10.3389/fmicb.2023.1109881
Frontiers in microbiology, Vol. 14 (february 2023)
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24.
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10 p, 577.6 KB |
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
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Mantegazza, Renato (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Wolfe, Gil I. (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Muppidi, Srikanth (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Wiendl, Heinz (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Fujita, Kenji P. (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
O'Brien, Fanny L. (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Booth, Heather D.E. (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Howard, James F (Fondazione IRCCS Istituto Neurologico Carlo Besta (R.M.) (Milà, Itàlia)) ;
Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Cortés-Vicente, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau) ;
Vidal-Fernández, Núria (Institut d'Investigació Biomèdica Sant Pau)
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. [...]
2021 - 10.1212/WNL.0000000000011207
Neurology, Vol. 96 Núm. 4 (january 2021) , p. e610-e618
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25.
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8 p, 937.1 KB |
Interstitial lung disease and anti-myeloperoxidase antibodies : Not a simple association
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Sebastiani, M. (Rheumatology Unit. Azienda Ospedaliera Policlinico di Modena. University of Modena and Reggio Emilia) ;
Luppi, F. (Department of Medicine and Surgery. University of Milano Bicocca. Respiratory Unit. San Gerardo Hospital. ASST di Monza) ;
Sambataro, G. (Regional Referral Centre for Rare Lung Diseases. A.O.U. "Policlinico-Vittorio Emanuele". Department of Clinical and Experimental Medicine. University of Catania) ;
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau) ;
Cerri, S. (Respiratory Unit. University of Modena and Reggio Emilia) ;
Tomietto, P. (Rheumatology Unit. University of Trieste) ;
Cassone, G. (PhD Program in Clinical and Experimental Medicine. University of Modena and Reggio Emilia) ;
Bocchino, M. (Department of Clinical Medicine and Surgery. Federico II University Hospital) ;
Atienza-Mateo, Belén (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Cameli, Paolo (University of Siena. Department of Medicine. Surgery & Neurosciences) ;
Moya, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Faverio, P. (Department of Medicine and Surgery. University of Milano Bicocca. Respiratory Unit. San Gerardo Hospital. ASST di Monza) ;
Bargagli, E. (Respiratory Diseases Unit. Department of Medical Sciences. Surgery and Neurosciences. Siena University) ;
Vancheri, C. (Regional Referral Centre for Rare Lung Diseases. A.O.U. "Policlinico-Vittorio Emanuele". Department of Clinical and Experimental Medicine. University of Catania) ;
Gonzalez-Gay, M.A. (Cardiovascular Pathophysiology and Genomics Research Unit. School of Physiology. Faculty of Health Sciences. University of the Witwatersrand) ;
Clini, E. (Respiratory Unit. University of Modena and Reggio Emilia) ;
Salvarani, C. (Rheumatology Unit. Irccs Arcispedale Santa Maria Nuova. Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia) ;
Manfredi, A. (Rheumatology Unit. Azienda Ospedaliera Policlinico di Modena. University of Modena and Reggio Emilia)
Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7-23% of these patients develops clinically overt vasculitis. [...]
2021 - 10.3390/jcm10122548
Journal of clinical medicine, Vol. 10 Núm. 12 (february 2021) , p. 2548
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26.
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11 p, 732.0 KB |
Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling : An individual-level analysis within 13 months in the ORCHESTRA cohort
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Collatuzzo, Giulia (Department of Medical and Surgical Sciences, University of Bologna) ;
De Palma, Giuseppe (University of Brescia) ;
Violante, Francesco S. (University of Verona) ;
Larese Filon, Francesca (University of Trieste) ;
Fabianova, Eleonora (Regional Authority of Public Health) ;
Violán, Concepció (Universitat Autònoma de Barcelona) ;
Vimercati, Luigi (University of Bari) ;
Leustean, Mihaela (National Institute of Public Health) ;
Rodriguez-Suarez, Marta Maria (Universidad de Oviedo) ;
Sansone, Emanuele (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Sala, Emma (ASST Ospedali Civili di Brescia) ;
Zunarelli, Carlotta (Universidad de Bologna) ;
Lodi, Vittorio (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Monaco, Maria Grazia Lourdes (University Hospital of Verona (Itàlia)) ;
Spiteri, Gianluca (University Hospital of Verona (Itàlia)) ;
Negro, Corrado (Unit of University of Trieste) ;
Beresova, Jana (Regional Authority of Public Health) ;
Carrasco-Ribelles, Lucia Amalía (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Tafuri, Silvio (Interdisciplinary Department of Medicine, University of Bari) ;
Asafo, Shuffield S. (Department of Medical and Surgical Sciences, University of Bologna) ;
Ditano, Giorgia (Department of Medical and Surgical Sciences, University of Bologna) ;
Abedini, Mahsa (Department of Medical and Surgical Sciences, University of Bologna) ;
Boffetta, Paolo (Stony Brook University)
We investigated changes in serologic measurements after COVID-19 vaccination in 19,422 subjects. An individual-level analysis was performed on standardized measurements. Age, infection, vaccine doses, time between doses and serologies, and vaccine type were associated with changes in serologic levels within 13 months. [...]
2023 - 10.3389/fimmu.2022.1079884
Frontiers in immunology, Vol. 13 (january 2023)
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27.
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11 p, 2.8 MB |
Malondialdehyde-modified HDL particles elicit a specific IgG response in abdominal aortic aneurysm
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Rodríguez-Carrio, J. (Universidad de Oviedo. Instituto de Salud Del Principado de Asturias (ISPA)) ;
Cerro-Pardo, Isabel (IIS-Fundación Jiménez-Díaz) ;
Lindholt, Jes S (Odense University Hospital (Dinamarca)) ;
Bonzon-Kulichenko, Elena (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Martínez-López, D. (IIS-Fundación Jiménez-Díaz) ;
Roldán-Montero, R. (IIS-Fundación Jiménez-Díaz) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Michel, J.B. (Inserm U1148) ;
Blanco-Colio, Luis Miguel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Vázquez, Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Suárez, A. (Universidad de Oviedo. Instituto de Salud Del Principado de Asturias (ISPA)) ;
Martín-Ventura, J.L. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
High Density Lipoprotein (HDL) plays a protective role in abdominal aortic aneurysm (AAA); however, recent findings suggest that oxidative modifications could lead to dysfunctional HDL in AAA. This study aimed at testing the effect of oxidized HDL on aortic lesions and humoral immune responses in a mouse model of AAA induced by elastase, and evaluating whether antibodies against modified HDL can be found in AAA patients. [...]
2021 - 10.1016/j.freeradbiomed.2021.08.004
Free Radical Biology and Medicine, Vol. 174 (october 2021) , p. 171-181
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28.
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29.
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17 p, 1.5 MB |
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA) : Rationale, Design, and Baseline Data
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Pagano, Gennaro (F Hoffmann-La Roche AG Research and Development Division) ;
Boess, Frank (Roche Pharma Research and Early Development) ;
Taylor, Kirsten I. (Faculty of Psychology. University of Basel) ;
Ricci, Benedicte (Roche Pharma Research and Early Development) ;
Mollenhauer, Brit ;
Poewe, Werner ;
Boulay, Anne ;
Anzures-Cabrera, Judith (Roche Products Ltd) ;
Vogt, Annamarie ;
Marchesi, Maddalena ;
Post, Anke ;
Nikolcheva, Tania ;
Kinney, Gene G. (Prothena Biosciences Inc. South San Francisco) ;
Zago, Wagner M. ;
Ness, Daniel K. ;
Svoboda, Hanno (F. Hoffmann-La Roche) ;
Britschgi, Markus ;
Ostrowitzki, Susanne ;
Simuni, Tanya ;
Marek, Kenneth (Institute for Neurodegenerative Disorders) ;
Koller, Martin ;
Sevigny, Jeff ;
Doody, Rachelle ;
Fontoura, Paulo ;
Umbricht, Daniel ;
Bonni, Azad ;
Altendorf, Claudia ;
Anandan, Chareyna ;
Andrews, Giulia ;
Ansquer, Solène ;
Arrouasse, Raphaele ;
Aslam, Sana ;
Azulay, Jean-Philippe ;
Baker, Jeanette ;
Balaguer Martinez, Ernest ;
Barbu, Shadi ;
Bardram, Kara ;
Bega, Danny ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Benatru, Isabelle ;
Benchetrit, Eve ;
Bernhard, Felix ;
Besharat, Amir ;
Bette, Sagari ;
Bichon, Amelie ;
Billnitzer, Andrew ;
Blondeau, Sophie ;
Boraud, Thomas ;
Borngräber, Freiderike ;
Boyd, James ;
Brockmann, Kathrin ;
Brodsky, Matthew ;
Brown, Ethan ;
Bruecke, Christof ;
Calvas, Fabienne ;
Canelo, Monica ;
Carbone, Federico ;
Carroll, Claire ;
Casado Fernandez, Laura ;
Cassé-Perrot, Catherine ;
Castrioto, Anna ;
Catala, Helene ;
Chan, Justine ;
Cheriet, Samia ;
Ciabarra, Aanthony ;
Classen, Joseph ;
Coleman, Juliana ;
Coleman, Robert ;
Compta, Yaroslau ;
Corbillé, Anne-Gaëlle ;
Corvol, Jean-Christophe ;
Cosgaya, Marina ;
Dahodwala, Nabila ;
Damier, Philippe ;
David, Elodie ;
Davis, Thomas ;
Dean, Marissa ;
Debilly, Berengere ;
DeGiorgio, Janell ;
Deik, Andres ;
Delaby, Laure ;
Delfini, Marie-Helene ;
Derkinderen, Pascal ;
Derost, Philipp ;
de Toledo, María ;
Deuel, Lisa ;
Diaz-Hernandez, Ann Marie ;
Dietiker, Cameron ;
Dimenshteyn, Karina ;
Dotor, Julio ;
Durif, Franck ;
Ebentheuer, Jens ;
Eggert, Karla Maria ;
Eichau Madueño, Sara ;
Eickhoff, Claudia ;
Ellenbogen, Aaron ;
Ellmerer, Philipp ;
Esparragosa Vazquez, Inés ;
Eusebio, Alexandre ;
Ewert, Siobhan ;
Fang, John ;
Feigenbaum, Danielle ;
Fluchere, Frederique ;
Foubert-Samier, Alexandra ;
Fournier, Marie ;
Fradet, Anne ;
Fraix, Valerie ;
Frank, Samuel ;
Fries, Franca ;
Galitzky, Monique ;
Gallardo Pérez, Marisol ;
Moreno, Jose Manuel García ;
Gasca, Carmen ;
Gasser, Thomas ;
Gibbons, Joyce ;
Giordana, Caroline ;
González Martinez, Alicia ;
Goodman, Ira ;
Gorospe, Arantza ;
Goubeaud, Marie ;
Grabli, David ;
Graziella, Mangone ;
Grimaldi, Stephan ;
Gross, Jeffrey ;
Guimaraes-Costa, Raquel ;
Hartmann, Andreas ;
Hartmann, Christian ;
Hassell, Travis ;
Hauser, Robert ;
Hernandez, Antonio ;
Hernández-Vara, Jorge ;
Hoeglinger, Günter ;
Homedes, Christian ;
Horta, Andrea ;
Houeto, Jean-Luc ;
Huebl, Julius ;
Hui, Jennifer ;
Isaacson, Stuart ;
Jankovic, Joseph ;
Janzen, Annette ;
Jauregui, Junior ;
Jiao, Jocelyne ;
Martí Domenech, María José ;
Joseph, Xavier ;
Kadimi, Srinath ;
Kaminski, Pat ;
Kannenberg, Silja ;
Kassubek, Jan ;
Katz, Maya ;
Klos, Kevin ;
Klos, Shannon ;
Kobet, Christopher ;
Koebert, Jennifer ;
Krause, Patricia ;
Kuehn, Andrea ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Kumar, Rajeev ;
Kunz, Martin ;
Kurvits, Lille ;
Kwei, Kimberly ;
Laganiere, Simon ;
Laurens, Brice ;
Levin, Johannes ;
Levy, Oren ;
LeWitt, Peter ;
Cristóbal, Gurutz Linazasoro ;
Litvan, Irene ;
Lizarraga, Karlo ;
Longardner, Katherine ;
Lopez, Rocío ;
López Manzanares, Lydia ;
Lucas del Pozo, Sara ;
Luquín Pulido, María Rosario ;
Luthra, Nijee ;
Lyons, Kelly ;
Maass, Sylvia ;
Machetanz, Gerrit ;
Macías, Yolanda ;
Maltete, David ;
Manez Miro, Jorge Uriel ;
Mariani, Louise-Laure ;
Marin, Juan ;
Marini, Kathrin ;
Marques, Ana ;
Marti, Gloria ;
Martí Domenech, María José ;
Martinez, Saul ;
Meissner, Wassilios ;
Meoni, Sara ;
Mollenhauer, Brit ;
Martinez, Dunia Mon ;
Moon, Johnson ;
Moro, Elena ;
Morrison, Peter ;
Muehlberg, Christoph ;
Multani, Manpreet ;
Murphy, Christine ;
Nicholas, Anthony ;
Pahwa, Rajesh ;
Palasí Franco, Antoni ;
Pape, Heidi ;
Patel, Neepa ;
Patel, Prity ;
Peball, Marina ;
Peckham, Elizabeth ;
Peery, Terry ;
Perez, Rafael ;
Perez, Jesús ;
Petit, Alisa ;
Pinkhardt, Elmar ;
Poewe, Werner ;
Pomies, Elsa ;
Preterre, Cecile ;
Quinn, Joseph ;
Rascol, Olivier ;
Remy, Philippe ;
Richard, Irene ;
Roeben, Benjamin ;
Ruether, Emily ;
Rumpf, Jost-Julian ;
Russell, David ;
Salhi, Hayet ;
Samaniego-Toro, Daniela ;
Samier-Foubert, Alexandra ;
Sánchez, Antonio ;
Schmitt, Emmanuelle ;
Schnitzler, Alfons ;
Schorr, Oliver ;
Schwartzbard, Julie ;
Schweyer, Kerstin ;
Seppi, Klaus ;
Sergo, Victoria ;
Shill, Holly ;
Siderowf, Andrew ;
Simuni, Tanya ;
Spampinato, Umberto ;
Sriram, Ashok ;
Stover, Natividad ;
Tanner, Caroline ;
Tarakad, Arjun ;
Taylor, Carolyn ;
Thalamus, Claire ;
Toothaker, Thomas ;
Van Blercom, Nadege ;
Vanegas-Arrogave, Nora ;
Vela, Lydia ;
Vergnet, Sylvian ;
Vidal, Tiphaine ;
Vöglein, Jonathan ;
Walsh, Ryan ;
Waters, Cheryl ;
Wegscheider, Mirko ;
Weidinger, Endy ;
Weill, Caroline ;
Wenzel, Gregor ;
Witjas, Tatiana ;
Wurster, Isabel ;
Wright, Brenton ;
Zimmermann, Milan ;
Zuzuarregui, Rafael ;
Abt, Markus ;
Bamdadian, Atieh ;
Barata, Teresa ;
Barbet, Nicholas ;
Belli, Sara ;
Boess, Frank ;
Bonni, Azad ;
Borroni, Edilio ;
Boulay, Anne ;
Britschgi, Markus ;
Chague, Jerome ;
Cosson, Valerie ;
Czech, Christian ;
Deptula, Dennis ;
Diack, Cheikh ;
Doody, Rachelle ;
Dukart, Juergen ;
D'Urso, Giulia ;
Dziadek, Sebastian (F. Hoffmann-La Roche) ;
Eddleston, Hannah ;
Edgar, Chris ;
Essioux, Laurent ;
Farell, Morgan ;
Finch, Rebecca (Roche Products Ltd) ;
Fontoura, Paulo ;
Gruenbauer, Waltraud ;
Hahn, Andreas ;
Holiga, Stefan (F. Hoffmann-La Roche) ;
Honer, Michael ;
Jadidi, Shirin ;
Johnson-Wood, Kelly ;
Keller, Markus ;
Kilchenmann, Timothy ;
Koller, Martin ;
Kremer, Thomas ;
Kustermann, Thomas (F. Hoffmann-La Roche) ;
Landsdall, Claire ;
Lindemann, Michael (F. Hoffmann-La Roche) ;
Lipsmeier, Florian ;
Luzy, Cecile ;
Manchester, Marianne ;
Marchesi, Maddalena ;
Martenyi, Ferenc ;
Martin-Facklam, Meret ;
Mironova, Katerina ;
Monnet, Annabelle (F. Hoffmann-La Roche) ;
Moore, Emma ;
Ness, Daniel K. ;
Niggli, Markus ;
Nikolcheva, Tania (F. Hoffmann-La Roche) ;
Ostrowitzki, Susanne ;
Passmard, Benedicte ;
Poirier, Agnes ;
Post, Anke ;
Prasad, Megana ;
Pross, Nathalie (F. Hoffmann-La Roche) ;
Quock, Tiffany ;
Rose, Ellen ;
Sarry, Christoph ;
Schubert, Christine ;
Selkoe, Dennis ;
Sevigny, Jeff ;
Sink, Kaycee ;
Staunton, Hannah ;
Steven, Tim ;
Strasak, Alexander ;
Svoboda, Hanno ;
Tripuraneni, Radhika ;
Trundell, Dylan ;
Umbricht, Daniel ;
Verselis, Lynne ;
Vogt, Annamarie ;
Volkova-Volkmar, Ekaterina ;
Weber, Cornelia ;
Weber, Silke ;
Zago, Wagner (Prothena Biosciences Inc. (San Francisco))
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. [...]
2021 - 10.3389/fneur.2021.705407
Frontiers in neurology, Vol. 12 (january 2021) , p. 705407
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11 p, 1.5 MB |
Long-term efficacy and safety of risankizumab for the treatment of moderate-to-severe plaque psoriasis : interim analysis of the LIMMitless open-label extension trial beyond 3 years of follow-up
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Papp, Kim A (K Papp Clinical Research and Probity Medical Research) ;
Lebwohl, M. G. (Icahn School of Medicine at Mount Sinai) ;
Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Ohtsuki, M. (Jichi Medical University) ;
Beissert, Stefan (Department of Dermatology. University Hospital Carl Gustav Carus. TU Dresden) ;
Zeng, J. (AbbVie Inc.) ;
Rubant, S. (AbbVie Inc.) ;
Sinvhal, R. (AbbVie Inc.) ;
Zhao, Y. (AbbVie Inc.) ;
Soliman, A.M. (AbbVie Inc.) ;
Alperovich, G. (AbbVie Inc.) ;
Leonardi, C. (Central Dermatology. Richmond Heights)
Background: Psoriasis is a chronic inflammatory skin disease requiring prolonged treatment. New biologic therapies require long-term evaluation to assess the durability of their efficacy and safety profiles over time. [...]
2021 - 10.1111/bjd.20595
British journal of dermatology, Vol. 185 Núm. 6 (december 2021) , p. 1135-1145
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