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Articles 41 registres trobats  inicianterior22 - 31següent  anar al registre: La cerca s'ha fet en 0.01 segons. 
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25 p, 4.2 MB Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells / Tishchenko, Alexander (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Azorín, Daniel D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vidal-Brime, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; José Muñoz, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jiménez Arenas, Pol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pearce, Christopher (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Girao, Henrique (University of Coimbra. Faculty of Medicine) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Connexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both pro- and anti-tumorigenic properties, but the mechanisms underlying these characteristics are not fully understood. [...]
2020 - 10.3390/cancers12102798
Cancers, Vol. 12 Núm. 10 (2020) , p. 2798  
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23.
9 p, 559.7 KB Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients / Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Somoza, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Maestu, Inmaculada (Hospital Universitari Doctor Peset (València)) ; Ureste, Maria Martín (Hospital Universitari Doctor Peset (València)) ; Sánchez Hernández, Alfredo (Consorci Hospitalari Provincial de Castelló) ; Córdoba Ortega, Juan Felipe (Hospital Arnau de Vilanova (Lleida, Catalunya)) ; Sansano, Irene (Hospital Universitari Vall d'Hebron) ; Venturas, Griselda (Hospital Universitari Vall d'Hebron) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Precision medicine has revolutionized the understanding and treatment of cancer by identifying subsets of patients who are amenable to specific treatments according to their molecular characteristics, as exemplified by epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). [...]
2019 - 10.1007/s40487-019-00099-9
Oncology and Therapy, Vol. 7 (august 2019) , p. 131-139  
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16 p, 1.6 MB Integrating clinical, molecular, proteomic and histopathological data within the tissue context : tissunomics / Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hümmer, Stefan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Peg, Vicente (Centro de Investigación Biomédica en Red de Cáncer) ; Matías-Guiu, Xavier (Hospital Universitari de Bellvitge) ; de Torres, Inés (Hospital Universitari Vall d'Hebron) ; Castellvi, Josep (Centro de Investigación Biomédica en Red de Cáncer) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vall d'Hebron Institut de Recerca (VHIR)
Malignant tumours show a marked degree of morphological, molecular and proteomic heterogeneity. This variability is closely related to microenvironmental factors and the location of the tumour. The activation of genetic alterations is very tissue-dependent and only few tumours have distinct genetic alterations. [...]
2019 - 10.1111/his.13828
Histopathology, Vol. 75 (may 2019) , p. 4-19  
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17 p, 1.3 MB Clinical implications of intratumor heterogeneity : challenges and opportunities / Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Capdevila, Claudia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; De Mattos-Arruda, Leticia (Vall d'Hebron Institut d'Oncologia) ; Diaz-Cano, Salvador J. (King's College Hospital NHS Foundation Trust) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. [...]
2020 - 10.1007/s00109-020-01874-2
Journal of Molecular Medicine (Berlin, Germany), Vol. 98 (january 2020) , p. 161-177  
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30 p, 7.5 MB The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer / De Mattos-Arruda, Leticia (Vall d'Hebron Institut d'Oncologia) ; Sammut, Stephen-John (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Ross, Edith M. (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Bashford-Rogers, Rachael (Department of Medicine. University of Cambridge) ; Greenstein, Erez (Weizmann Institute of Science (Israel). Department of Immunology) ; Markus, Havell (Mayo Clinic Center for Individualized Medicine) ; Morganella, Sandro (Department of Medical Genetics. The Clinical School. University of Cambridge) ; Teng, Yvonne (Cancer Molecular Diagnosis Laboratory. NIHR Cambridge Biomedical Research Centre) ; Maruvka, Yosef (Massachusetts General Hospital (Boston)) ; Pereira, Bernard (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Rueda, Oscar M. (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Chin, Suet-Feung (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Contente-Cuomo, Tania (Mayo Clinic Center for Individualized Medicine) ; Mayor, Regina (Centro de Investigación Biomédica en Red de Cáncer) ; Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ; Ali, H. Raza (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Cope, Wei (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Tiezzi, Daniel (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Dariush, Aliakbar (Institute of Astronomy. University of Cambridge) ; Dias Amarante, Tauanne (Department of Medical Genetics. The Clinical School. University of Cambridge) ; Reshef, Dan (Weizmann Institute of Science (Israel). Department of Immunology) ; Ciriaco, Nikaoly (Hospital Universitari Vall d'Hebron) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ; Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ; Vassiliou, George (Wellcome Trust/MRC Cambridge Stem Cell Institute) ; Getz, Gad (Massachusetts General Hospital (Boston)) ; Nik-Zainal, Serena (Department of Medical Genetics. The Clinical School. University of Cambridge) ; Murtaza, Muhammed (Mayo Clinic Center for Individualized Medicine) ; Friedman, Nir (Weizmann Institute of Science (Israel). Department of Immunology) ; Markowetz, Florian (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ; Seoane Suárez, Joan (Vall d'Hebron Institut d'Oncologia) ; Caldas, Carlos (Cancer Research UK Cambridge Cancer Centre (Regne Unit)) ; Universitat Autònoma de Barcelona
The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. [...]
2019 - 10.1016/j.celrep.2019.04.098
Cell reports, Vol. 27 Núm. 9 (28 2019) , p. 2690-2708.e10  
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27.
20 p, 5.5 MB Insight into the role and regulation of gap junction genes in lung cancer and identification of nuclear Cx43 as a putative biomarker of poor prognosis / Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sansano, Irene (Hospital Universitari Vall d'Hebron) ; Montero, María Ángeles (Hospital Universitari Vall d'Hebron) ; Romagosa, Cleofé (Hospital Universitari Vall d'Hebron) ; Temprana-Salvador, Jordi (Hospital Universitari Vall d'Hebron) ; Martinez-Marti, Alex (Hospital Universitari Vall d'Hebron) ; Moliné, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández-Losa, J. (Centro de Investigación Biomédica en Red de Cáncer) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. [...]
2019 - 10.3390/cancers11030320
Cancers, Vol. 11 Núm. 3 (march 2019) , p. 320  
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28.
12 p, 8.9 MB Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions / Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Calucho, Maite (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castro, Zoraida (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ortega-Aznar, Arantxa (Hospital Universitari Vall d'Hebron) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (University of Toronto) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Bone morphogenetic proteins (BMPs) are secreted proteins that belong to the transforming growth factor-β superfamily. In the adult brain, they modulate neurogenesis, favor astrogliogenesis, and inhibit oligodendrogenesis. [...]
2019 - 10.1016/j.ajpath.2018.11.007
American Journal of Pathology, Vol. 189 Núm. 3 (march 2019) , p. 665-676  
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8 p, 425.0 KB Characterization of Kelch domain-containing protein 7B in breast tumours and breast cancer cell lines / Martín-Pardillos, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón Y Cajal, Santiago (Hospital Universitari Vall d'Hebron)
Adenocarcinomas exhibit great heterogeneity, with many genetic and epigenetic alterations. The Kelch domain-containing protein 7B (KLHDC7B) has recently been identified as epigenetically modified and upregulated in breast cancer. [...]
2019 - 10.3892/ol.2019.10672
Oncology Letters, Vol. 18 Núm. 3 (september 2019) , p. 2853-2860  
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30.
11 p, 2.1 MB Interplay between ncRNAs and cellular communication : A proposal for understanding cell-specific signaling pathways / Ramón y Cajal, Santiago (Centro de Investigación Biomédica en Red de Cáncer) ; Segura, M. F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hümmer, Stefan (Centro de Investigación Biomédica en Red de Cáncer) ; Universitat Autònoma de Barcelona
Intercellular communication is essential for the development of specialized cells, tissues, and organs and is critical in a variety of diseases including cancer. Current knowledge states that different cell types communicate by ligand-receptor interactions: hormones, growth factors, and cytokines are released into the extracellular space and act on receptors, which are often expressed in a cell-type-specific manner. [...]
2019 - 10.3389/fgene.2019.00281
Frontiers in genetics, Vol. 10 Núm. APR (2019) , p. 281  
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12 p, 4.1 MB Brain ApoA-I, ApoJ and ApoE immunodetection in cerebral amyloid angiopathy / Camacho, Jessica (Hospital Universitari Vall d'Hebron) ; Moliné, Teresa (Hospital Universitari Vall d'Hebron) ; Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ; Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron)
Cerebral amyloid angiopathy (CAA) is a common cause of lobar intracerebral hemorrhage (ICH) in elderly individuals and it is the result of the cerebrovascular deposition of beta-amyloid (Ab) protein. [...]
2019 - 10.3389/fneur.2019.00187
Frontiers in neurology, Vol. 10 (2019) , p. 187  
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Articles : 41 registres trobats   inicianterior22 - 31següent  anar al registre:
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