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Articles 93 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
1.
9 p, 964.3 KB Experts document on methotrexate use in combined therapy with biological or targeted synthetic disease modifying drugs in patients with rheumatoid arthritis Documento de expertos sobre el uso de terapia combinada de metotrexato con terapias biológicas o terapias dirigidas a pacientes con artritis reumatoide / Tornero-Molina, J. (Hospital de Guadalajara) ; Alperi-López, M. (Hospital Universitario Central de Asturias) ; Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ; de Agustín, Juan José (Hospital Universitari Vall d'Hebron) ; Escudero, A. (Hospital Universitario Reina Sofía) ; García-Vicuña, R. (Hospital Universitario La Princesa) ; González-Gay, M.Á. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Hidalgo, C. (Complejo Asistencial Universitario de Salamanca) ; Rubio, E. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Sanmartí, Raimon (Hospital Clínic i Provincial de Barcelona) ; Casamira, N. (Laboratorios Gebro Pharma) ; Calvo Alén, Jaime (Hospital Universitario Araba) ; Universitat Autònoma de Barcelona
We aimed to develop recommendations for the management of methotrexate (MTX) when considering the combination with biological (b) or targeted synthetic (ts) disease modifying drugs (DMARDs) in rheumatoid arthritis (RA). [...]
2022 - 10.1016/j.reuma.2020.08.003
Reumatologia Clinica, Vol. 18 Núm. 1 (enero 2022) , p. 33-41  
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2.
10 p, 659.8 KB A Pharmacovigilance Study in First Episode of Psychosis : Psychopharmacological Interventions and Safety Profiles in the PEPs Project / Bioque, Miquel (Hospital Clínic i Provincial de Barcelona) ; Llerena, Adrián (Universidad de Extremadura) ; Cabrera, Bibiana (Hospital Clínic i Provincial de Barcelona) ; Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona) ; Lobo, Antonio (Universidad de Zaragoza) ; González-Pinto, Ana (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ; Díaz-Caneja, Covadonga M. (Hospital General Universitario Gregorio Marañón) ; Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau) ; Aguilar, Eduardo J. (Hospital Clínic València) ; Bulbena Vilarrasa, Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ; Castro-Fornieles, Josefina (Hospital Clínic i Provincial de Barcelona) ; Vieta, Eduard (Hospital Clínic i Provincial de Barcelona) ; Lafuente, Amàlia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Mas, Sergi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Parellada, Mara (Hospital General Universitario Gregorio Marañón) ; Saiz-Ruiz, Jerónimo (Hospital Ramon y Cajal) ; Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra) ; Bernardo, Miguel (Universitat de Barcelona) ; Gassó, P. ; Amoretti, S. ; García Bernardo, E. ; Tapia-Casellas, C. ; Alonso-Solís, Anna (Institut d'Investigació Biomèdica Sant Pau) ; Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau) ; Hernández, M. ; González, I. ; Ruiz, P. ; Modrego, F. ; Escartí, M.J. ; Mané, Anna ; Torrent, C. ; Baeza, I. ; Contreras, F. ; Albacete, A. ; Bobes, Julio ; García-Portilla, Maria Paz ; Zabala Rabadán, A. ; Segarra Echevarría, R. ; Rodriguez-Jimenez, R. ; Morales-Muñoz, I. ; Butjosa, A. ; Landin-Romero, R. ; Sarró, S. ; Ibáñez, Á. ; Sánchez-Torres, A.M. ; Balanzá-Martínez, Vicent ; Universitat Autònoma de Barcelona
The characterization of the first episode of psychosis and how it should be treated are principal issues in actual research. Realistic, naturalistic studies are necessary to represent the entire population of first episode of psychosis attended in daily practice. [...]
2016 - 10.1093/ijnp/pyv121
International journal of neuropsychopharmacology, Vol. 19 Núm. 4 (january 2016)  
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3.
49 p, 3.2 MB Cancer epigenetics in clinical practice / Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute to the acquisition of hallmark tumor capabilities by regulating gene expression programs that promote tumorigenesis. [...]
2023 - 10.3322/caac.21765
CA Cancer Journal for Clinicians, Vol. 73 Núm. 4 (2023) , p. 376-424  
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4.
18 p, 347.3 KB Fraternidad política y enfermedades raras / Puyol González, Àngel 1968- (Universitat Autònoma de Barcelona)
Rare diseases generally receive less funding for their medical research and treatments than other diseases. Apart from well-known scientific and economic explanations, there are two major ethical positions regarding this fact, the one that approves it for reasons of utilitarian ethics, and the one that condemns it by insisting on egalitarian and individual rights reasons. [...]
2021 - 10.12795/ARAUCARIA.2021.I46.17
Araucaria: revista Iberoamericana de filosofía, política, humanidades y relaciones internacionales, Núm. 46 (2021) , p. 351-368  
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5.
5 p, 1.6 MB Stabilization and Binding of [V4O12]4− and Unprecedented [V20O54(NO3)]n− to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug VIVO(acetylacetonato)2 / Ferraro, Giarita (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ; Tito, Gabriella (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ; Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ; Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ; Merlino, Antonello (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)
High-resolution crystal structures of lysozyme in the presence of the potential drug VIVO(acetylacetonato)2 under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of VIV to VV and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V4O12]4−, which interacts with lysozyme non-covalently, and the unprecedented [V20O54(NO3)]n−, which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.
2023 - 10.1002/anie.202310655
Angewandte Chemie (International ed. Internet), Vol. 62, Issue 50 (December 2023) , art. e202310655  
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6.
8 p, 615.7 KB Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors : role of immunosuppresors and failure of antiretrovirals / Roc, Lourdes (Hospital Universitario Miguel Servet (Saragossa)) ; De Mendoza, Carmen (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Fernández-Alonso, Miriam (Clinica Universitaria (Pamplona)) ; Reina, Gabriel (Clinica Universitaria (Pamplona)) ; Soriano, Vicente (Facultad de Ciencias de la Salud UNIR) ; Caballero Requero, Estrella (Hospital Universitari Vall d'Hebron) ; Molina Romero, Israel (Hospital Universitari Vall d'Hebron) ; Manzardo, Christian (Hospital Clínic i Provincial de Barcelona) ; Miró, Josep M. (Hospital Clínic i Provincial de Barcelona) ; Escudero, Domingo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Niubó, Jordi (Hospital Universitari de Bellvitge) ; Margall, Núria (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. [...]
2019 - 10.1177/2049936119868028
Therapeutic Advances in Infectious Disease, Vol. 6 (2019) , p. 1-8  
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7.
16 p, 2.1 MB Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies : a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology / Grávalos, Cristina (Hospital Universitario 12 de Octubre (Madrid)) ; Sanmartín, O. (Fundació Institut Valencià d'Oncologia) ; Gúrpide, A. (Clínica Universidad de Navarra) ; España, A. (Clínica Universidad de Navarra) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Suh Oh, H.J. (Complejo Hospitalario Universitario de Pontevedra) ; Aragón, I. (Complejo Hospitalario Universitario de Huelva) ; Segura, S. (Hospital del Mar (Barcelona, Catalunya)) ; Beato, C. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Botella, R. (Instituto de Investigación Sanitaria La Fe) ; Universitat Autònoma de Barcelona
Progress in the understanding of many tumors has enabled the development of new therapies, such as those targeted at specific molecules involved in cell growth (targeted therapies) or intended to modulate the immune system (immunotherapy). [...]
2019 - 10.1007/s12094-018-1953-x
Clinical & Translational Oncology, Vol. 21 Núm. 5 (january 2019) , p. 556-571  
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8.
10 p, 536.2 KB Prevention of stroke in patients with chronic coronary syndromes or peripheral arterial disease / Parker, W.A.E. (University of Sheffield) ; Gorog, D.A. (University of Hertfordshire) ; Geisler, T. (University of Tübingen) ; Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Sibbing, D. (Medizinische Klinik und Poliklinik I. Campus Großhadern) ; Rocca, B. (Catholic University) ; Storey, R.F. (University of Sheffield) ; Universitat Autònoma de Barcelona
Stroke is a common and devastating condition caused by atherothrombosis, thromboembolism, or haemorrhage. Patients with chronic coronary syndromes (CCS) or peripheral artery disease (PAD) are at increased risk of stroke because of shared pathophysiological mechanisms and risk-factor profiles. [...]
2021 - 10.1093/EURHEARTJ/SUAA165
European heart journal supplements, Vol. 22 (2021) , p. M26-M34  
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9.
11 p, 132.7 KB Los retos de la reducción de daños como política pública de drogas en Brasil / Moraes, Maristela (Universidade Federal de Campina Grande (Brazil)) ; Montenegro Martínez, Marisela (Universitat Autònoma de Barcelona. Departament de Psicologia Social) ; Medrado, Benedito (Universidade Federal de Pernambuco (Brazil). Departamento de Psicologia) ; Romaní, Oriol 1951- (Universitat Rovira i Virgili)
La implementación de las políticas públicas de la reducción de daños en Brasil ha sido objeto de múltiples debates. Tratamos de las principales tensiones de este campo a partir del análisis de 15 documentos de políticas de salud en Brasil. [...]
The implementation of harm reduction public policies in Brazil has been discussed in many studies. We approached the main tensions in this field based on the analysis of 15 documents related to health policies in Brazil. [...]
2015 - 10.24879/20150090020015
Psicologia em Pesquisa, Vol. 9 Núm. 2 (Julho-Dezembro 2015) , p. 148-158  
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10.
10 p, 982.7 KB Trends in cause-specific mortality : deaths of despair in Spain, 1980-2019 / Piñeiro, Bárbara (Centre d'Estudis Demogràfics) ; Spijker, Jeroen (Centre d'Estudis Demogràfics) ; Trias-Llimós, Sergi (Centre d'Estudis Demogràfics) ; Blanes, Amand (Centre d'Estudis Demogràfics) ; Permanyer, Iñaki (Centre d'Estudis Demogràfics)
Background: Research from various countries has shown increases in alcohol- and drug-related deaths and suicide, known as 'deaths of despair' over recent decades, particularly among low-educated middle-aged individuals. [...]
2023 - 10.1093/pubmed/fdad133
Journal of public health, June 2023, p. 1-19  
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