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11.
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8 p, 275.5 KB |
Pirfenidone for Idiopathic Pulmonary Fibrosis and Beyond
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Aimo, Alberto (Fondazione Toscana Gabriele Monasterio) ;
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nieri, Dario (Pisa University Hospital) ;
Tavanti, Laura Maria (Pisa University Hospital) ;
Meschi, Claudia (University of Pisa) ;
Panichella, Giorgia (Scuola Superiore Sant'Anna) ;
Lupón, Josep (Instituto de Salud Carlos III) ;
Pistelli, Francesco (Pisa University Hospital) ;
Carrozzi, Laura (University of Pisa) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Emdin, Michele (Fondazione Toscana Gabriele Monasterio) ;
Universitat Autònoma de Barcelona
Pirfenidone (PFD) slows the progression of idiopathic pulmonary fibrosis (IPF) by inhibiting the exaggerated fibrotic response and possibly through additional mechanisms, such as anti-inflammatory effects. [...]
2022 -  10.15420/cfr.2021.30
Cardiac Failure Review, Vol. 8 (april 2022)
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12.
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21 p, 722.6 KB |
Sex-Related Differences in Mortality Following Admission for Acute Heart Failure Across the Left Ventricular Ejection Fraction Spectrum
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Santas, Enrique (Universitat de València) ;
Palau, Patricia (Universitat de València) ;
Llàcer, Pau (Hospital Universitario Ramón y Cajal (Madrid)) ;
De la Espriella, Rafael (Universitat de València) ;
Miñana, Gema (Universitat de València) ;
Núñez-Marín, Gonzalo (Universitat de València) ;
Lorenzo, Miguel (Universitat de València) ;
Heredia, Raquel (Universitat de València) ;
Sanchis, Juan (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Chorro, Francisco J (Universitat de València) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Núñez, Julio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Following a heart failure (HF)-decompensation, there is scarce data about sex-related prognostic differences across left ventricular ejection fraction (LVEF) status. We sought to evaluate sex-related differences in 6-month mortality risk across LVEF following admission for acute HF. [...]
2021 - 10.1161/JAHA.121.022404
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 11 (december 2021)
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13.
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0 p, 3.6 MB |
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
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Rohde, David (Massachusetts General Hospital and Harvard Medical School) ;
Vandoorne, Katrien (Massachusetts General Hospital and Harvard Medical School) ;
Lee, I-Hsiu (Department of Radiology, Massachusetts General Hospital) ;
Grune, Jana (Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ;
Zhang, Shuang (Department of Radiology, Massachusetts General Hospital) ;
McAlpine, Cameron S. (Department of Radiology, Massachusetts General Hospital) ;
Schloss, Maximilian J. (Department of Radiology, Massachusetts General Hospital) ;
Nayar, Ribhu (Department of Radiology, Massachusetts General Hospital) ;
Courties, Gabriel (Department of Radiology, Massachusetts General Hospital) ;
Frodermann, Vanessa (Department of Radiology, Massachusetts General Hospital) ;
Wojtkiewicz, Gregory (Massachusetts General Hospital) ;
Honold, Lisa (Department of Radiology, Massachusetts General Hospital) ;
Chen, Qi (Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ;
Schmidt, Stephen (Massachusetts General Hospital) ;
Iwamoto, Yoshiko (Massachusetts General Hospital) ;
Sun, Yuan (Department of Radiology, Massachusetts General Hospital) ;
Cremer, Sebastian (Department of Radiology, Massachusetts General Hospital) ;
Hoyer, Friedrich F. (Department of Radiology, Massachusetts General Hospital) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol) ;
Ji, Fei (Department of Molecular Biology, Massachusetts General Hospital) ;
Zhou, Bin (Chinese Academy of Sciences) ;
Adams, Ralf H. (Max Planck Institute for Molecular Biomedicine (Alemanya)) ;
Wythe, Joshua D. (Department of Molecular Physiology and Biophysics, Baylor College of Medicine (Estats Units d'Amèrica)) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Watanabe, Hideto (Aichi Medical University) ;
Jung, Yookyung (Massachusetts General Hospital) ;
van der Laan, Anja M. (Department of Cardiology, University of Amsterdam) ;
Piek, Jan J. (Department of Cardiology, University of Amsterdam) ;
Kfoury, Youmna (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Désogère, Pauline A. (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Vinegoni, Claudio (Department of Radiology, Massachusetts General Hospital) ;
Dutta, Partha (Department of Medicine, University of Pittsburgh School of Medicine) ;
Sadreyev, Ruslan I. (Department of Pathology, Massachusetts General Hospital and Harvard Medical School) ;
Caravan, Peter (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ;
Libby, Peter (Department of Medicine, Brigham and Women's Hospital) ;
Scadden, David T. (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Lin, Charles P. (Aichi Medical University) ;
Naxerova, Kamila (Department of Radiology, Massachusetts General Hospital) ;
Swirski, Filip K. (Department of Radiology, Massachusetts General Hospital) ;
Nahrendorf, Matthias (Department of Internal Medicine I, University Hospital Wuerzburg)
Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic leukocyte pool, but whether cardiovascular disease affects the hematopoietic organ's microvasculature is unknown. [...]
2021 - 10.1038/s44161-021-00002-8
Nature cardiovascular research, Vol. 1 (december 2021) , p. 28-44
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14.
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21 p, 1.6 MB |
A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
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de la Fuente, Ana (Clínica Universidad de Navarra) ;
Santisteban, Marta (Clínica Universidad de Navarra) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aramendía, José Manuel (Clínica Universidad de Navarra) ;
Díaz, Agnes (Clínica Universidad de Navarra) ;
Santaballa, Ana (Instituto de Investigación Sanitaria La Fe) ;
Hernándiz, Amparo (Instituto de Investigación Sanitaria La Fe) ;
Sepúlveda, Pilar (Instituto de Investigación Sanitaria La Fe) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López, Begoña (Clínica Universidad de Navarra) ;
Picazo, José María López (Clínica Universidad de Navarra) ;
Mazo, Manuel M. (Clínica Universidad de Navarra) ;
Rábago, Gregorio (Clínica Universidad de Navarra) ;
Gavira, Juan José (Clínica Universidad de Navarra) ;
García-Bolao, Ignacio (Clínica Universidad de Navarra) ;
Díez, Javier (Clínica Universidad de Navarra) ;
González, Arantxa (Clínica Universidad de Navarra) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ravassa, Susana (Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona
Left ventricular dysfunction (LVD) induced by anthracycline-based cancer chemotherapy (ACC) is becoming an urgent healthcare concern. Myocardial fibrosis (MF) may contribute to LVD after ACC. We show that elevated circulating levels of procollagen type I C-terminal propeptide (PICP, biomarker of MF) are associated with early subclinical LVD and predict later development of cardiotoxicity in patients treated with ACC. [...]
2022 - 10.3390/cancers14122941
Cancers, Vol. 14 (june 2022)
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15.
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11 p, 850.5 KB |
Non-STEMI vs. STEMI Cardiogenic Shock : Clinical Profile and Long-Term Outcomes
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Martínez, María José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rueda, Ferran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Labata, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Oliveras, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Montero, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer Vinardel, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
El Ouaddi, Nabil (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Garcia Garcia, Cosme (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Cardiogenic shock (CS) is a severe complication of acute myocardial infarction (AMI). In AMI-CS, the ST segment deviation on ECG may be elevated (STEMI-CS) or non-elevated (NSTEMI-CS), which may influence prognosis. [...]
2022 - 10.3390/jcm11123558
Journal of clinical medicine, Vol. 11 (june 2022)
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16.
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6 p, 260.7 KB |
Atrial Mitral and Tricuspid Regurgitation : Sex Matters. A Call for Action to Unravel the Differences Between Women and Men
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Gual-Capllonch, Francisco (Clínica Rotger) ;
Sáenz de Ibarra, José Ignacio (Clínica Rotger) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Delgado, Victoria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Atrial functional regurgitation is caused by atrioventricular annulus dilation, with normal leaflets and ventricular dimensions and function within the normal range. Its occurrence, in both mitral and tricuspid valves, implies a worse prognosis due to the hemodynamic derangement they produce, but also constitutes a marker of greater comorbidity and more advanced disease. [...]
2022 - 10.3389/fcvm.2022.877592
Frontiers in Cardiovascular Medicine, Vol. 9 (june 2022)
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17.
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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 - 10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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18.
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12 p, 16.7 MB |
Practical outpatient management of worsening chronic heart failure
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Girerd, Nicolas (Université de Lorraine) ;
Mewton, Nathan (University Claude Bernard Lyon) ;
Tartière, Jean-Michel (Hôpital Sainte-Musse) ;
Guijarro, Damien (Université de Nantes) ;
Jourdain, Patrick (Assistance Publique-Hôpitaux de Paris) ;
Damy, Thibaud (CHU d'Henri-Mondor) ;
Lamblin, Nicolas (Université de Lille) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pellicori, Pierpaolo (University of Glasgow) ;
Januzzi, James L. (Harvard Medical School) ;
Rossignol, Patrick (Université de Lorraine) ;
Roubille, François (CHU de Montpellier) ;
Universitat Autònoma de Barcelona
Management of worsening heart failure (WHF) has traditionally been hospital-based, but with the rising burden of heart failure (HF), the pressure on healthcare systems exerted by this disease necessitates a different strategy than long (and costly) hospital stays. [...]
2022 - 10.1002/ejhf.2503
European Journal of Heart Failure, Vol. 24 (april 2022) , p. 750-761
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19.
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14 p, 2.0 MB |
Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non-ischaemic dilated cardiomyopathy
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Mirelis, Jesús G. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Escobar-Lopez, Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Ochoa, Juan Pablo (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Espinosa, María Ángeles (Hospital General Universitario Gregorio Marañón) ;
Villacorta, Eduardo (Universidad de Salamanca) ;
Navarro Peñalver, Marina (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Casas, Guillem (Hospital Universitari Vall d'Hebron) ;
Mora-Ayestarán, Nerea (Complejo Hospitalario de Navarra) ;
Barriales-Villa, Roberto (Universidade da Coruña) ;
Mogollón-Jiménez, María Victoria (Complejo Hospitalario Universitario de Cáceres) ;
García-Pinilla, José Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
García-Granja, Pablo Elpidio (Hospital Clínico Universitario Valladolid) ;
Climent, Vicente (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Palomino-Doza, Julian (Hospital 12 de Octubre (Madrid)) ;
García-Álvarez, Ana (Hospital Clínic i Provincial de Barcelona) ;
Álvarez-Barredo, María (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Cabrera-Borrego, Eva (Hospital Universitario Virgen de las Nieves (Granada)) ;
Ripoll-Vera, Tomás (Hospital Universitario Son Llatzer & IdISBa) ;
Peña-Peña, María Luisa (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Rodríguez-González, Elena (Hospital General Universitario Gregorio Marañón) ;
Gallego-Delgado, María (Gerencia Regional de Salud de Castilla y León (SACYL)) ;
Gonzalez-Carrillo, Josefa (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Fernández-Ávila, Ana (Hospital General Universitario Gregorio Marañón) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron) ;
Brugada, Ramon (Hospital Universitari de Girona Doctor Josep Trueta) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dominguez, Fernando (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
García-Pavía, Pablo (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Genotype and left ventricular scar on cardiac magnetic resonance (CMR) are increasingly recognized as risk markers for adverse outcomes in non-ischaemic dilated cardiomyopathy (DCM). We investigated the combined influence of genotype and late gadolinium enhancement (LGE) in assessing prognosis in a large cohort of patients with DCM. [...]
2022 - 10.1002/ejhf.2514
European Journal of Heart Failure, Vol. 24 (may 2022) , p. 1183-1196
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20.
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13 p, 3.5 MB |
Electrophysiological effects of adipose graft transposition procedure (AGTP) on the post-myocardial infarction scar : A multimodal characterization of arrhythmogenic substrate
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Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Falguera, Daina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Curiel, Carolina (Boston Scientific Department. Barcelona Delegation) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marsal, Roger (Boston Scientific Department. Barcelona Delegation) ;
Rodríguez-Leor, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fadeuilhe, Edgar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aranyó, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sarrias, Axel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bazán, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Andrés-Cordón, Joan Francesc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villuendas-Sabaté, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bisbal, Felipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
To assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar. Myocardial repair is a promising treatment for patients with MI. [...]
2022 - 10.3389/fcvm.2022.983001
Frontiers in Cardiovascular Medicine, Vol. 9 (september 2022)
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