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11.
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8 p, 4.5 MB |
Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage
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Matute-Blanch, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brito, Verónica (Universitat de Barcelona. Departament de Biomedicina) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Luisa M (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Garcia-Diaz Barriga, Gerardo (Universitat de Barcelona. Departament de Biomedicina) ;
Guzman de la Fuente, Alerie (Queen's University Belfast) ;
Borràs, Eva (Universitat Pompeu Fabra) ;
Fernández-García, Sara (Universitat de Barcelona. Departament de Biomedicina) ;
Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Miguez, Andrés (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Costa-Frossard, Lucienne (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Pinteac, Rucsanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sabidó, Eduard (Barcelona Institute of Science and Technology (BIST)) ;
Alberch i Vié, Jordi (Universitat de Barcelona. Departament de Biomedicina) ;
Fitzgerald, Denise C. (Queen's University Belfast) ;
Montalban, Xavier (Universitat de Barcelona. Departament de Biomedicina) ;
Comabella, Manuel (Universitat de Barcelona. Departament de Biomedicina)
2022 -  10.1002/ctm2.837
Clinical and Translational Medicine, Vol. 12 (may 2022)
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12.
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14 p, 2.2 MB |
Associations of with clinico-radiological measures in a large population
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Sotirchos, Elias S. (Johns Hopkins University School of Medicine) ;
Fitzgerald, Kathryn (Johns Hopkins University School of Medicine) ;
Singh, Carol (Biogen) ;
Smith, Matthew D. (Johns Hopkins University School of Medicine) ;
Reyes-Mantilla, Maria (Johns Hopkins University School of Medicine) ;
Hersh, Carrie (Cleveland Clinic) ;
Hyland, Megan H. (University of Rochester Medical Center) ;
Canissario, Ryan (University of Rochester Medical Center) ;
Simmons, Sarah B. (Mellen Center, Neurological Institute, Cleveland Clinic) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Naismith, Robert (Washington University in St. Louis) ;
Qiao, Min (Washington University in St. Louis) ;
Krupp, Lauren B. (New York University) ;
Nicholas, Jacqueline A. (Riverside Methodist Hospital) ;
Akgün, Katja (University Clinic Carl-Gustav Carus) ;
Ziemssen, Tjalf (University Clinic Carl-Gustav Carus) ;
Rudick, Richard ((formerly) Biogen) ;
Fisher, Elizabeth (Biogen) ;
Bermel, Robert (Mellen Center, Neurological Institute, Cleveland Clinic) ;
Mowry, Ellen (Johns Hopkins University School of Medicine) ;
Calabresi, Peter A. (Johns Hopkins University School of Medicine) ;
Universitat Autònoma de Barcelona
Evaluation of serum neurofilament light chain (sNfL), measured using high-throughput assays on widely accessible platforms in large, real-world MS populations, is a critical step for sNfL to be utilized in clinical practice. [...]
2022 - 10.1002/acn3.51704
Annals of Clinical and Translational Neurology, Vol. 10 (november 2022) , p. 84-97
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13.
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10 p, 509.3 KB |
Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
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Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis. What are the long-term outcomes of patients developing progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis? In this longitudinal cohort study including 1128 patients with a first demyelinating event in multiple sclerosis, presenting with PIRA was associated with significantly shorter times to developing severe disability compared with not presenting with PIRA. [...]
2022 - 10.1001/jamaneurol.2022.4655
JAMA Neurology, Vol. 80 (december 2022) , p. 151-160
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14.
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11 p, 711.9 KB |
Transcription-based prediction of response to IFNbeta using supervised computational methods
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Baranzini, Sergio E. (University of California, San Francisco) ;
Mousavi, Parvin (Queen's University, Kingston, Ontario) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron) ;
Caillier, Stacy J. (University of California, San Francisco) ;
Stillman, Althea (University of California, San Francisco) ;
Villoslada, Pablo (Clínica Universidad de Navarra) ;
Wyatt, Mathew M. (University of California, San Francisco) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Greller, Larry D. (Biosystemix, Sydenham, Ontario) ;
Somogyi, Roland (Biosystemix, Sydenham, Ontario) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (University of California, San Francisco)
Changes in cellular functions in response to drug therapy are mediated by specific transcriptional profiles resulting from the induction or repression in the activity of a number of genes, thereby modifying the preexisting gene activity pattern of the drug-targeted cell(s). [...]
2005 - 10.1371/journal.pbio.0030002
PLoS biology, Vol. 3 Núm. 1 (2005) , art. e2
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15.
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9 p, 404.0 KB |
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis
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Alcina, Antonio (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Fedetz, Maria (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Fernández, Óscar (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Lucas, Miguel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Leyva, Laura (Hospital Regional Universitario Carlos Haya (Málaga)) ;
García-León, Juan Antonio (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Abad-Grau, María del Mar (Universidad de Granada) ;
Alloza, Iraide (Universidad del País Vasco) ;
Antigüedad, Alfredo (Hospital de Basurto (Bilbao, Biscaia)) ;
Garcia-Barcina, María J. (Hospital de Basurto (Bilbao, Biscaia)) ;
Vandenbroeck, Koen (Universidad del País Vasco) ;
Varadé, Jezabel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
de la Hera, Belén (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Arroyo, Rafael (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Petit-Marty, Natalia (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Navarro, Arcadi 1969- (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Olascoaga, Javier (Hospital Universitario Donosti) ;
Blanco, Yolanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra")
Background and aim: Several studies have highlighted the association of the 12q13. 3-12q14. 1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants underlying diseases are still unclear. [...]
2013 - 10.1136/jmedgenet-2012-101085
Journal of medical genetics, Vol. 50, Issue 1 (May 2013) , p. 25-33
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16.
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14 p, 1.9 MB |
Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis
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Carrión, Belinda (Hospital Universitari Vall d'Hebron) ;
Liu, Yawei ;
Hadi, Mahdieh (Hospital Universitari Vall d'Hebron) ;
Lundstrom, Jon (Hospital Universitari Vall d'Hebron) ;
Christensen, Jeppe Romme (Hospital Universitari Vall d'Hebron) ;
Ammitzbøll, Cecilie (Hospital Universitari Vall d'Hebron) ;
Dziegiel, Morten Hanefeld (Hospital Universitari Vall d'Hebron) ;
Sørensen, Per Soelberg (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Sellebjerg, Finn (Hospital Universitari Vall d'Hebron) ;
Issazadeh-Navikas, Shohreh (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The aim of this study was to determine whether natural killer T (NKT) cells, including invariant (i) NKT cells, have clinical value in preventing the progression of multiple sclerosis (MS) by examining the mechanisms by which a distinct self-peptide induces a novel, protective invariant natural killer T cell (iNKT cell) subset. [...]
2021 - 10.1212/NXI.0000000000001065
Neurology® neuroimmunology & neuroinflammation, Vol. 8 (august 2021)
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17.
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22 p, 6.8 MB |
Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis
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Camacho-Toledano, Celia (Hospital Nacional de Parapléjicos-SESCAM) ;
Machín-Díaz, Isabel (Hospital Nacional de Parapléjicos-SESCAM) ;
Calahorra, Leticia (Hospital Nacional de Parapléjicos-SESCAM) ;
Cabañas-Cotillas, María (Hospital Nacional de Parapléjicos-SESCAM) ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Castillo-Triviño, Tamara (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Villar, Luisa M (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
García-Domínguez, José Manuel (Hospital General Universitario Gregorio Marañón) ;
García-Arocha, Jennifer (Hospital Nacional de Parapléjicos-SESCAM) ;
Ortega, María Cristina (Hospital Nacional de Parapléjicos-SESCAM) ;
Clemente, Diego (Hospital Nacional de Parapléjicos-SESCAM) ;
Universitat Autònoma de Barcelona
The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medicine. [...]
2022 - 10.1186/s12974-022-02635-3
Journal of neuroinflammation, Vol. 19 (november 2022)
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18.
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10 p, 1.5 MB |
Angiogenin in the Neurogenic Subventricular Zone After Stroke
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Gabriel Salazar, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lei, Ting (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grayston, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Medina-Gutiérrez, Esperanza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Ischemic stroke is a leading cause of death and disability worldwide with effective acute thrombolytic treatments. However, brain repair mechanisms related to spontaneous or rehabilitation-induced recovery are still under investigation, and little is known about the molecules involved. [...]
2021 - 10.3389/fneur.2021.662235
Frontiers in neurology, Vol. 12 (june 2021)
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19.
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6 p, 333.0 KB |
Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab
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Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pignolet, Beatrice (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vermersch, Patrick (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruet, Aurélie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
deSèze, Jerome (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Labauge, Pierre (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vukusic, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Papeix, Caroline (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Almoyna, Laurent (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tourbah, Ayman (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clavelou, Pierre (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moreau, Thibault (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pelletier, Jean (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lebrun-Frenay, Christine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bourre, Bertrand (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Defer, Gilles (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brassat, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The study aimed to assess the potential for serum neurofilament light chain (NFL) levels to predict the risk of progressive multifocal leukoencephalopathy (PML) in natalizumab (NTZ)-treated patients with multiple sclerosis (MS) and to discriminate PML from MS relapses. [...]
2021 - 10.1212/NXI.0000000000001003
Neurology® neuroimmunology & neuroinflammation, Vol. 8 (april 2021)
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20.
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6 p, 201.9 KB |
Pharmacogenomic study in patients with multiple sclerosis
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Bustamante, Marta F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morcillo-Suarez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Leyva, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zettl, Uwe K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Killestein, Joep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brassat, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Merino, Juan Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Antonio J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Urcelay, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Lafuente, Roberto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Lusia M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Farré, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lechner-Scott, Jeannette (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vandenbroeck, Koen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Antigüedad, Alfredo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinelli Boneschi, Filippo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chan, Andrew (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Arcadi, 1969- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aimed to investigate the association between polymorphisms located in type I interferon (IFN)-induced genes, genes belonging to the toll-like receptor (TLR) pathway, and genes encoding neurotransmitter receptors and the response to IFN-β treatment in patients with multiple sclerosis (MS). [...]
2015 - 10.1212/NXI.0000000000000154
Neurology® neuroimmunology & neuroinflammation, Vol. 2 (september 2015)
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