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11.
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9 p, 227.9 KB |
Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease : Results from the MOPEAD project
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Boada, Mercè (Universitat Internacional de Catalunya) ;
Rodrigo, Adrián (GMV SECURE E SOLUTIONS) ;
Jessen, Frank (Faculty of Medicine and University Hospital Cologne) ;
Wimblad, Bengt (Karolinska Univ Hospital) ;
Kramberger, Milica G. (Univerza V Ljubljani) ;
Visser, Pieter Jelle (Maastricht University) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Gomez, Octavio (Universitat Internacional de Catalunya) ;
Ciudin, Andreea (Hospital Universitari Vall d'Hebron) ;
Georges, Jean (Alzheimer Europe) ;
Dumas, Annete (ASDM Consulting) ;
Maguire, Peggy (European Institute of Women's Health) ;
Krivec, David (Zdruzenje Spomincica) ;
Wimo, Anders (Karolinska Institutet (Estocolm, Suècia)) ;
Valero, Sergi (Instituto de Salud Carlos III) ;
Alegret, Montserrat (Instituto de Salud Carlos III) ;
Jamilis, Laura (GMV SECURE E SOLUTIONS) ;
Zwan, Marissa (Vrije Universiteit Amsterdam) ;
Sannemann, Lena (Faculty of Medicine and University Hospital Cologne) ;
Arrufat, Jordi (EAP Sarrià-Vallvidrera-Les Planes) ;
Stomrud, Erik (Region Kalmar County) ;
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia)) ;
Glaysher, Bridget (Modus Research and Innovation Limited) ;
Stewart, Neil (Modus Research and Innovation Limited) ;
Belger, Mark (Eli Lilly and Company (Lilly UK)) ;
Iradier, Fatima (Eli Lilly and Company) ;
Campo, Laura (Eli Lilly and Company) ;
Universitat Autònoma de Barcelona
The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. [...]
2021 -  10.1002/alz.12441
Alzheimer's & Dementia, Vol. 18 (july 2021) , p. 1119-1127
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12.
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13 p, 2.1 MB |
Magnetic Bead Handling Using a Paper-Based Device for Quantitative Point-of-Care Testing
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Arias-Alpízar, Kevin (Hospital Universitari Vall d'Hebron) ;
Sánchez-Cano, Ana (Hospital Universitari Vall d'Hebron) ;
Prat-Trunas, Judit (Hospital Universitari Vall d'Hebron) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron) ;
Salvador, Fernando (Hospital Universitari Vall d'Hebron) ;
Oliveira, Inés (Hospital Universitari Vall d'Hebron) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron) ;
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Baldrich Rubio, Eva (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Microfluidic paper-based analytical devices (μPADs) have been extensively proposed as ideal tools for point-of-care (POC) testing with minimal user training and technical requirements. However, most μPADs use dried bioreagents, which complicate production, reduce device reproducibility and stability, and require transport and storage under temperature and humidity-controlled conditions. [...]
2022 - 10.3390/bios12090680
Biosensors, Vol. 12 (august 2022)
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13.
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14 p, 625.5 KB |
Automated Systems for Calculating Arteriovenous Ratio in Retinographies : A Scoping Review
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García-Sierra, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Lifante, Victor M. (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Isusquiza Garcia, Erik (ULMA Medical Technologies, S. Coop) ;
Heras, Antonio (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Besada, Idoia (ULMA Medical Technologies, S. Coop) ;
Verde Lopez, David (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Alzamora, M. Teresa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Forés Raurell, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Montero-Alía, Pilar (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Ugarte Anduaga, Jurgi (ULMA Medical Technologies, S. Coop) ;
Torán Montserrat, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
There is evidence of an association between hypertension and retinal arteriolar narrowing. Manual measurement of retinal vessels comes with additional variability, which can be eliminated using automated software. [...]
2022 - 10.3390/diagnostics12112865
Diagnostics, Vol. 12 (november 2022)
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14.
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7 p, 1000.2 KB |
Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk
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Consegal, Marta (Hospital Universitari Vall d'Hebron) ;
Barba, Ignasi (Hospital Universitari Vall d'Hebron) ;
García del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ;
Otaegui, Imanol (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron) ;
Martí Balaguer, Gerard (Hospital Universitari Vall d'Hebron) ;
Serra-Vidal, Bernat (Hospital Universitari Vall d'Hebron) ;
Bellera Gotarda, Neus (Hospital Universitari Vall d'Hebron) ;
Ojeda-Ramos, Manuel (Hospital Universitari Vall d'Hebron) ;
Valente, Filipa (Hospital Universitari Vall d'Hebron) ;
Carmona, Maria Ángeles (Hospital Universitari Vall d'Hebron) ;
Miró-Casas, Elisabet (Hospital Universitari Vall d'Hebron) ;
Sambola, Antonia (Hospital Universitari Vall d'Hebron) ;
Lidón, Rosa María (Hospital Universitari Vall d'Hebron) ;
Bañeras, Jordi (Hospital Universitari Vall d'Hebron) ;
Barrabés, José A (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Benito, Begoña (Hospital Universitari Vall d'Hebron) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron) ;
Inserte Igual, Javier (Hospital Universitari Vall d'Hebron) ;
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Succinate is enhanced during initial reperfusion in blood from the coronary sinus in ST-segment elevation myocardial infarction (STEMI) patients and in pigs submitted to transient coronary occlusion. [...]
2023 - 10.1038/s41598-023-34196-7
Scientific reports, Vol. 13 (april 2023)
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15.
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11 p, 1.7 MB |
Identification of decreased intrinsic capacity : Performance of diagnostic measures of the ICOPE Screening tool in community dwelling older people in the VIMCI study
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Rojano i Luque, Xavier (Universitat Autònoma de Barcelona. Fundació Salut i Envelliment) ;
Blancafort Alias, Sergi (Universitat Autònoma de Barcelona. Fundació Salut i Envelliment) ;
Prat Casanovas, Susanna (Institut Català de la Salut) ;
Forné, Susanna (Fundació Sant Hospital (Lleida, Espanya)) ;
Martín Vergara, Nuria (Institut Català de la Salut) ;
Fabregat Povill, Pilar (Hospital de la Santa Creu (Tortosa, Espanya)) ;
Vila Royo, Maria (Badalona Serveis Assistencials) ;
Serrano, Rosa (EDP Salut Sant Joan (Reus, Espanya)) ;
Sánchez-Rodríguez, Dolores (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vílchez Saldaña, Montserrat (Institut Català de la Salut) ;
Martínez, Iris (Fundació Sant Hospital (Lleida, Espanya)) ;
Domínguez López, Mariola (Hospital de la Santa Creu (Tortosa, Espanya)) ;
Riba Porquet, Francesc (Hospital de la Santa Creu (Tortosa, Espanya)) ;
Intxaurrondo González, Aimar (Institut d'Investigació Biomèdica Sant Pau) ;
Salvà Casanovas, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The World Health Organization (WHO) has developed the Integrated Care for Older People (ICOPE) strategy to face the challenges of ageing societies. This strategy is focused on person centered care and the assessment intrinsic capacity (IC). [...]
2023 - 10.1186/s12877-023-03799-0
BMC geriatrics, Vol. 23 (february 2023)
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16.
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0 p, 691.1 KB |
Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity
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Haimel, Matthias (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Pazmandi, Julia (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Heredia, Raú Jiménez (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Dmytrus, Jasmin (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Bal, Sevgi Köstel (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Zoghi, Samaneh (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
van Daele, Paul (Erasmus University Medical Center (Rotterdam)) ;
Briggs, Tracy A. (University of Manchester) ;
Wouters, Carine (University Hospitals Leuven (Bèlgica)) ;
Bader-Meunier, Brigitte (Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE) (Paris)) ;
Aeschlimann, Florence A. (Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE),(Paris)) ;
Caorsi, Roberta (IRCCS Istituto Giannina Gaslini, Genova) ;
Eleftheriou, Despina (Hospital for Children NHS Foundation Trust (London)) ;
Hoppenreijs, Esther (Radboud University Medical Centre (Nijmegen)) ;
Salzer, Elisabeth (Medical University of Vienna) ;
Bakhtiar, Shahrzad (Goethe University) ;
Derfalvi, Beata (Dalhousie University/IWK Health Centre Halifax) ;
Saettini, Francesco (University of Milano Bicocca) ;
Kusters, Maaike A. A. (Hospital for Children NHS Foundation Trust) ;
Elfeky, Reem (Hospital for Children NHS Foundation Trust (London)) ;
Trück, Johannes (University Children's Hospital Zurich) ;
Rivière, Jacques G.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van der Burg, Mirjam (Leiden University Medical Center) ;
Gattorno, Marco (IRCCS Istituto Giannina Gaslini (Genova)) ;
Seidel, Markus G. (Medical University Graz) ;
Burns, Siobhan (Royal Free Hospital NHS Foundation Trust) ;
Warnatz, Klaus (University of Freiburg) ;
Hauck, Fabian (Ludwig-Maximilians-Universität München (Munich)) ;
Brogan, Paul (Hospital for Children NHS Foundation Trust (London)) ;
Gilmour, Kimberly C. (Hospital for Children NHS Foundation Trust (London)) ;
Schuetz, Catharina (Technische Universität Dresden) ;
Simon, Anna (Radboud University Nijmegen Medical Centre) ;
Bock, Christoph (Medical University of Vienna) ;
Hambleton, Sophie (Newcastle University) ;
de Vries, Esther (Elisabeth-Tweesteden Hospital (Tilburg)) ;
Robinson, Peter N. (The Jackson Laboratory for Genomic Medicine (Farmington)) ;
van Gijn, Marielle (University Medical Center Groningen) ;
Boztug, Kaan (Medical University of Vienna) ;
Universitat Autònoma de Barcelona
Accurate, detailed, and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. [...]
2021 - 10.1016/j.jaci.2021.04.033
The Journal of Allergy and Clinical Immunology, Vol. 149 (may 2021) , p. 369-378
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17.
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26 p, 520.6 KB |
Molecularización, genetización y centros de referencia : el Instituto de Bioquímica Clínica de Barcelona (1969-1980)
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Velasco Morgado, Raúl (Universidad de Salamanca)
En conjunto, la molecularización y la genetización de la biomedicina del siglo XX construyeron un enorme listado de enfermedades, la mayoría raras, con unas necesidades asistenciales muy específicas, una gran dependencia del laboratorio e importantes dificultades para la creación de expertos. [...]
En conjunto, la molecularización y la genetización de la biomedicina del siglo XX construyeron un enorme listado de enfermedades, la mayoría raras, con unas necesidadesasistenciales muy específicas, una gran dependencia del laboratorio e importantes dificultades para la creación de expertos. [...]
Taken together, the molecularization and geneticization of biomedicine during the 20th century produced a long list of diseases, mostly rare, with very specific needs, a high dependence on the laboratory, and substantial difficulties in the creation of experts. [...]
2022 - 10.30827/dynamis.v42i2.27714
Dynamis : Acta Hispanica ad Medicinae Scientiarumque. Historiam Illustrandam, Vol. 42 Núm. 2 (2022) , p. 371-396 (Dossier)
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18.
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15 p, 1.7 MB |
Preliminary validity of the Draw a Shape Test for upper extremity assessment in multiple sclerosis
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Graves, Jennifer S. (University of California San Diego) ;
Ganzetti, Marco (F. Hoffmann-La Roche Ltd, Basel) ;
Dondelinger, Frank (F. Hoffmann-La Roche Ltd, Basel) ;
Lipsmeier, Florian (F. Hoffmann-La Roche Ltd, Basel) ;
Belachew, Shibeshih (F. Hoffmann-La Roche Ltd, Basel) ;
Bernasconi, Corrado (F. Hoffmann-La Roche Ltd, Basel) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Beek, Johan van (F. Hoffmann-La Roche Ltd, Basel) ;
Baker, Michael (F. Hoffmann-La Roche Ltd, Basel) ;
Gossens, Christian (F. Hoffmann-La Roche Ltd, Basel) ;
Lindemann, Michael (F. Hoffmann-La Roche Ltd, Basel) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective To validate the smartphone sensor-based Draw a Shape Test - a part of the Floodlight Proof-of-Concept app for remotely assessing multiple sclerosis-related upper extremity impairment by tracing six different shapes. [...]
2023 - 10.1002/acn3.51705
Annals of Clinical and Translational Neurology, Vol. 10 Núm. 2 (2023) , p. 166-180
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19.
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15 p, 348.7 KB |
Bioinformatic Tools for NGS-Based Metagenomics to Improve the Clinical Diagnosis of Emerging, Re-Emerging and New Viruses
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Ibañez-Lligoña, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Colomer-Castell, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
González-Sánchez, Alejandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Campos, Carolina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Garcia-Cehic, D (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Piñana, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rodríguez Frías, Francisco (Universitat Internacional de Catalunya) ;
Antón, Andrés (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Epidemics and pandemics have occurred since the beginning of time, resulting in millions of deaths. Many such disease outbreaks are caused by viruses. Some viruses, particularly RNA viruses, are characterized by their high genetic variability, and this can affect certain phenotypic features: tropism, antigenicity, and susceptibility to antiviral drugs, vaccines, and the host immune response. [...]
2023 - 10.3390/v15020587
Viruses, Vol. 15, Issue 2 (February 2023) , art. 587
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20.
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19 p, 6.0 MB |
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in down syndrome
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D'Acunzo, Pasquale (New York University. School of Medicine. Department of Psychiatry) ;
Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Kim, Yohan (New York University. School of Medicine. Department of Psychiatry) ;
Hargash, Tal (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Miller, Chelsea (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Alldred, Melissa J. (Department of Psychiatry. New York University. School of Medicine) ;
Erdjument-Bromage, Hediye (New York University. School of Medicine. Kimmel Center for Biology and Medicine. The Skirball Institute) ;
Penikalapati, Sai Charan (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Pawlik, Monika (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Saito, Mitsuo (Division of Neurochemistry. Nathan S. Kline Institute for Psychiatric Research) ;
Saito, Mariko (New York University School of Medicine. Department of Psychiatry) ;
Ginsberg, Stephen D. (New York University. School of Medicine. Department of Neuroscience and Physiology) ;
Neubert, Thomas A. (Kimmel Center for Biology and Medicine. The Skirball Institute. New York University. School of Medicine) ;
Goulbourne, Chris N. (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Levy, Efrat (Department of Biochemistry and Molecular Pharmacology. New York University. School of Medicine)
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes. [...]
2021 - 10.1126/sciadv.abe5085
Science advances, Vol. 7 Núm. 7 (december 2021) , p. eabe5085
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