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Articles 115 records found  previous11 - 20nextend  jump to record: Search took 0.00 seconds. 
11.
15 p, 1.6 MB A trans-omics assessment of gene-gene interaction in early-stage NSCLC / Chen, Jiajin (Nanjing Medical University) ; Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ; Li, Yi (Department of Biostatistics. University of Michigan) ; Wei, Yongyue (Nanjing Medical University) ; Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ; Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ; You, Dongfang (Department of Biostatistics. Nanjing Medical University) ; Su, Li (Harvard Medical School) ; Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ; Karlsson, Anna (Department of Clinical Sciences. Lund University) ; Planck, Maria (Department of Clinical Sciences. Lund University) ; Staaf, Johan (Department of Clinical Sciences. Lund University) ; Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ; Esteller, M (Universitat de Barcelona) ; Shen, Hongbing (Nanjing Medical University) ; Christiani, David C. (Harvard Medical School) ; Zhang, Ruyang (Nanjing Medical University) ; Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 - 10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187  
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12.
18 p, 15.6 MB Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease / Garrido-Trigo, Alba (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Corraliza, Ana Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Veny, Marisol (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Dotti, Isabella (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Melón-Ardanaz, Elisa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rill, Aina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Crowell, Helena L. (Department of Molecular Life Sciences. University of Zurich. Switzerland. SIB Swiss Institute of Bioinformatics) ; Corbí, Ángel (Centro de Investigaciones Biológicas. Consejo Superior de Investigaciones Científicas (CSIC)) ; Gudiño, Victoria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Esteller, Miriam (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Álvarez-Teubel, Iris (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Aguilar, Daniel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Masamunt, M.Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Killingbeck, E. (NanoString Technologies) ; Kim, Youngmi (NanoString Technologies) ; Leon, Michael (NanoString Technologies) ; Visvanathan, Sudha (Translational Medicine and Clinical Pharmacology. Boehringer-Ingelheim Pharmaceuticals Inc) ; Marchese, Domenica (Centre de Regulació Genòmica) ; Caratù, Ginevra (Centre de Regulació Genòmica) ; Martin Cardona, Albert (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Esteve, Maria (Department of Gastroenterology. Hospital Universitari Mútua Terrassa. Universitat de Barcelona) ; Panés, Julian (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Ricart, Elena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Heyn, Holger (Universitat Pompeu Fabra) ; Salas, Azucena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. [...]
2023 - 10.1038/s41467-023-40156-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 4506  
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13.
16 p, 5.1 MB MSIMEP : Predicting microsatellite instability from microarray DNA methylation tumor profiles / Santamarina-García, Martín (University of Santiago de Compostela) ; Brea-Iglesias, Jenifer (University of Santiago de Compostela) ; Bramsen, Jesper Bertram (Aarhus University Hospital (Aarhus, Dinamarca)) ; Fuentes-Losada, Mar (University of Santiago de Compostela) ; Caneiro-Gómez, Francisco Javier (University of Santiago de Compostela) ; Vázquez-Bueno, Jose Ángel (Complejo Hospitalario Universitario de Ferrol) ; Lázare-Iglesias, Hector (University of Santiago de Compostela) ; Fernández-Díaz, Natalia (University of Santiago de Compostela) ; Sánchez-Rivadulla, Laura (Complejo Hospitalario Universitario de Ferrol) ; Betancor, Yoel Z. (University of Santiago de Compostela) ; Ferreiro-Pantín, Miriam (University of Santiago de Compostela) ; Conesa-Zamora, Pablo (Santa Lucía University Hospital) ; Antúnez-López, José Ramon (University of Santiago de Compostela) ; Kawazu, Masahito (Chiba Cancer Center, Research Institute, Chiba, Japan) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Andersen, Claus Lindbjerg (Aarhus University Hospital (Aarhus, Dinamarca)) ; Tubio, Jose M.C. (University of Santiago de Compostela) ; López-López, Rafael (Centro de Investigación Biomédica en Red de Cáncer) ; Ruiz-Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer)
Deficiency in DNA MMR activity results in tumors with a hypermutator phenotype, termed microsatellite instability (MSI). Beyond its utility in Lynch syndrome screening algorithms, today MSI has gained importance as predictive biomarker for various anti-PD-1 therapies across many different tumor types. [...]
2023 - 10.1016/j.isci.2023.106127
iScience, Vol. 26 Núm. 3 (february 2023)  
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14.
19 p, 2.4 MB Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects / Petazzi, Paolo (Instituto de Salud Carlos III) ; Jorge-Torres, Olga Caridad (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ; Scognamiglio, Iolanda (Institut d'Investigació Biomèdica de Bellvitge) ; Serra-Musach, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ; Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Grases, Daniela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Xiol, Clara (Hospital Sant Joan de Déu (Manresa)) ; O'Callaghan, Maria del Mar (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Armstrong, Judith (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Rett syndrome (RTT) is a severe neurodevelopmental disease caused almost exclusively by mutations to the MeCP2 gene. This disease may be regarded as a synaptopathy, with impairments affecting synaptic plasticity, inhibitory and excitatory transmission and network excitability. [...]
2023 - 10.3390/ijms24021453
International journal of molecular sciences, Vol. 24 Núm. 2 (january 2023)  
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15.
12 p, 16.0 MB Gastric metaplasia as a precursor of nonconventional dysplasia in inflammatory bowel disease / Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gené, Míriam (Hospital Universitari Joan XXIII de Tarragona) ; Cuatrecasas, Míriam (Hospital Clínic i Provincial de Barcelona) ; Amat, Irene (Complejo Hospitalario de Navarra) ; Veiga, Jesús Alberto (Complejo Hospitalario Universitario de Ferrol) ; Fernández-Aceñero, María Jesús (Hospital Clínico San Carlos (Madrid)) ; Chimisana, Victòria Fusté (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Tarragona, Jordi (Hospital Arnau de Vilanova (Lleida, Catalunya)) ; Jurado, Ismael (Consorci Sanitari de Terrassa) ; Fernández-Victoria, Rebeca (Hospital Álvaro Cunqueiro (Vigo)) ; Martínez-Ciarpaglini, Carolina (Hospital Clínic Universitari (València)) ; Alenda González, Cristina (Hospital General Universitario Dr. Balmis) ; Zac, Carlos (Hospital Universitari I Politècnic La Fe) ; Fernández-Figueras, María Teresa (Universitat Internacional de Catalunya) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Gastric metaplasia in colonic mucosa with inflammatory bowel disease (IBD) develops as an adaptation mechanism. The association between gastric metaplasia and nonconventional and/or conventional dysplasia as precursors of colitis-associated colorectal cancer is unknown. [...]
2024 - 10.1016/j.humpath.2023.11.011
Human Pathology, Vol. 143 (january 2024) , p. 50-61  
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16.
9 p, 1.5 MB Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome / García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Musulen, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685  
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17.
6 p, 909.0 KB Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells / Siqueira, E (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Kim, Bo-Hyun (Department of Biochemistry and Microbiology. University of Victoria) ; Reser, Larry (Department of Chemistry. University of Virginia) ; Chow, Robert (Department of Biology. University of Victoria) ; Delaney, Kerry (Department of Biology. University of Victoria) ; Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ; Ross, Mark M. (Department of Chemistry. University of Virginia) ; Shabanowitz, Jeffrey (Department of Chemistry. University of Virginia) ; Hunt, Donald F. (Department of Pathology. University of Virginia) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ausiö, Juan (Department of Biochemistry and Microbiology. University of Victoria)
An immortalized neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin compositional transitions undergone during differentiation, with special emphasis on linker histones. [...]
2023 - 10.1080/15592294.2023.2276425
Epigenetics, Vol. 18 Núm. 1 (2023) , p. 2276425  
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18.
17 p, 4.7 MB Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas / Gallardo-Gómez, María (Universidade de Vigo) ; Rodríguez-Girondo, Mar (Department of Medical Statistics and Bioinformatics. Leiden University Medical Centre) ; Planell, Núria (Universidad Pública de Navarra) ; Moran, Sebastián (Institut d'Investigació Biomèdica de Bellvitge) ; Bujanda, Luis (Universidad del País Vasco. Instituto de Investigación Sanitaria Biodonostia) ; Etxart, Ane (Department of Surgery. Hospital Universitario Donostia) ; Castells, Antoni (Universitat de Barcelona) ; Balaguer, Francesc (Universitat de Barcelona) ; Jover, Rodrigo (Servicio de Medicina Digestiva. Universidad Miguel Hernández) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Cubiella, Joaquin (Department of Gastroenterology. Complexo Hospitalario Universitario de Ourense. Instituto de Investigación Biomédica Galicia Sur. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Gómez-Cabrero, David (Mucosal & Salivary Biology Division. King's College London Dental Institute) ; De Chiara, Loretta (Galicia Sur Health Research Institute) ; Universitat Autònoma de Barcelona
Background: Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. [...]
2023 - 10.1186/s13148-023-01570-1
Clinical Epigenetics, Vol. 15 Núm. 1 (december 2023) , p. 157  
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19.
13 p, 6.3 MB Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome / Noguera-Castells, Aleix (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans. On top of that, the DNA methylome undergoes profound changes in cancer and other disorders. [...]
2023 - 10.1080/15592294.2023.2185742
Epigenetics, Vol. 18 Núm. 1 (december 2023)  
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20.
23 p, 7.0 MB MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer / Alburquerque-Béjar, Juan Jos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Navajas-Chocarro, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Saigi, Maria (Department of Medical Oncology. Catalan Institute of Oncology (ICO)) ; Ferrero-Andres, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Morillas, Juan M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vilarrubi, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ; Mate, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Munoz-Marmol, Ana M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Romero, Octavio A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pros, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Llabata, Paula (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Torres-Diz, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteve-Codina, Anna (Universitat Pompeu Fabra) ; Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates programmed death-ligand 1 (PD-L1) levels. [...]
2023 - 10.1016/j.xcrm.2023.101006
Cell Reports Medicine, Vol. 4 Núm. 4 (april 2023)  
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64 Esteller, M
1 Esteller, M.,
10 Esteller, Manel
2 Esteller, Miriam
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