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Articles 201 records found  previous11 - 20nextend  jump to record: Search took 0.00 seconds. 
11.
7 p, 979.4 KB pCRP-mCRP dissociation mechanisms as potential targets for the development of small-molecule anti-inflammatory chemotherapeutics / Caprio, Vittorio (Manchester Metropolitan University) ; Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ; Di Napoli, Mario (Ospedale San Camillo de Lellis) ; Fang, Wen-Hui (Manchester Metropolitan University) ; Ferris, Glenn R. (Manchester Metropolitan University) ; Guo, Baoqiang (Weifang Medical University) ; Iemma, Rocco S. (Manchester Metropolitan University) ; Liu, Donghui (University of Medicine and Pharmacy) ; Zeinolabediny, Yasmin (University of Medicine and Pharmacy) ; Slevin, Mark (University of Medicine and Pharmacy) ; Universitat Autònoma de Barcelona
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important disease states including cardiovascular disease and neurodegenerative disorders such as Alzheimer's disease. [...]
2018 - 10.3389/fimmu.2018.01089
Frontiers in immunology, Vol. 9 Núm. MAY (28 2018) , p. 1089  
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12.
9 p, 8.0 MB Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse / Rapöhn, Inka (University of Leipzig) ; Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Weiner, Juliane (University of Leipzig Medical Center) ; Pujol, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Kehr, Stephanie (Leipzig University) ; Chadt, Alexandra (German Center for Diabetes Research) ; Al-Hasani, Hadi (German Center for Diabetes Research) ; Burkhardt, Ralph (University Hospital Regensburg) ; Klöting, Nora (University of Leipzig) ; Stumvoll, Michael (University of Leipzig) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Kovacs, Peter (German Center for Diabetes Research) ; Heiker, John T. (University of Leipzig Medical Center) ; Breitfeld, Jana (Leipzig Medical Center)
Adipose tissue inflammation and insulin resistance are hallmarks in the development of metabolic diseases resulting from overweight and obesity, such as type 2 diabetes and non-alcoholic fatty liver disease. [...]
2023 - 10.3389/fendo.2023.1146454
Frontiers in Endocrinology, Vol. 14 (April 2023) , art. 1146454  
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13.
12 p, 867.4 KB Cross-talk between lipoproteins and inflammation : The role of microvesicles / Chiva-Blanch, Gemma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Atherothrombosis is the principal underlying cause of cardiovascular disease (CVD). Microvesicles (MV) are small blebs originated by an outward budding at the cell plasma membranes, which are released in normal conditions. [...]
2019 - 10.3390/jcm8122059
Journal of clinical medicine, Vol. 8 Núm. 12 (december 2019) , p. 2059  
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14.
15 p, 2.7 MB Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination / Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prats, Anna (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ; Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Muñoz-Moreno, Jose A. (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ; Hanke, Thomas (University of Oxford. The Jenner Institute) ; Moltó, José (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Universitat Autònoma de Barcelona. Departament de Medicina) ; Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Biomarkers predicting the outcome of HIV-1 virus control in natural infection and after therapeutic interventions in HIV-1 cure trials remain poorly defined. The BCN02 trial (NCT02616874), combined a T-cell vaccine with romidepsin (RMD), a cancer-drug that was used to promote HIV-1 latency reversal and which has also been shown to have beneficial effects on neurofunction. [...]
2023 - 10.1016/j.ebiom.2023.104732
EBioMedicine, Vol. 95 (september 2023)  
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15.
21 p, 2.8 MB Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity / Parra-Perez, Alberto M. (GENYO. Centre for Genomics and Oncological Research: Pfizer. Universidad de Granada) ; Pérez-Jiménez, Amalia (Universidad de Granada. Departamento de Zoología. Facultad de Ciencias) ; Gris-Cárdenas, Isabel (CIC bioGUNE. Centre for Cooperative Research in Biosciences) ; Bonel-Pérez, Gloria C. (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ; Carrasco-Díaz, Luis Miguel (Institut d'Investigació Biomèdica Sant Pau) ; Mokhtari, khalida (Mohammed I University. Laboratory of Bioresources. Biotechnologies. Ethnopharmacology and Health. Department of Biology. Faculty of Sciences) ; García-Salguero, Encarnacion Leticia (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ; Lupiáñez, José Antonio (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ; Rufino-Palomares, Eva E. (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ; Universitat Autònoma de Barcelona
Hydroxytyrosol (HT), the main representative of polyphenols of olive oil, has been described as one of the most powerful natural antioxidants, also showing anti-inflammatory, antimicrobial, cardioprotective and anticancer activity in different type of cancers, but has been little studied in hematological neoplasms. [...]
2022 - 10.3390/ijms23137053
International journal of molecular sciences, Vol. 23 Núm. 13 (july 2022) , p. 7053  
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16.
19 p, 1.4 MB Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro : Implications for age-related macular degeneration / Romero-Vázquez, Sara (Hospital Clínic i Provincial de Barcelona) ; Adan Civera, Alfredo (Hospital Clínic i Provincial de Barcelona) ; Figueras-Roca, Marc (Hospital Clínic i Provincial de Barcelona) ; Llorenç, Victor (Hospital Clínic i Provincial de Barcelona) ; Slevin, M. (Manchester Metropolitan University) ; Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ; Dick, Andrew D (University College London Institute of Ophthalmology) ; Molins, Blanca (Hospital Clínic i Provincial de Barcelona) ; Universitat Autònoma de Barcelona
The retinal pigment epithelium (RPE) is considered one of the main targets of age-related macular degeneration (AMD), the leading cause of irreversible vision loss among the ageing population worldwide. [...]
2020 - 10.18632/aging.103655
Aging (Albany NY), Vol. 12 Núm. 14 (31 2020) , p. 13905-13923  
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17.
22 p, 4.5 MB Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice / López-Estévez, Sergio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Aguilera Pujabet, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gris, Georgia (Welab Barcelona) ; de la Puente, Beatriz (Welab Barcelona) ; Carceller, Alicia (Welab Barcelona) ; Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sigma-1 receptors (σRs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σRs on acute colitis-associated hypersensitivity using both genetic (constitutive knockout) and pharmacological blockade of the receptor. [...]
2023 - 10.3390/biomedicines11102758
Biomedicines, Vol. 11 (october 2023)  
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18.
12 p, 2.1 MB Glycoprotein profile assessed by1h-nmr as a global inflammation marker in patients with HIV infection. A prospective study / Malo, Ana-Irene (Universitat Rovira i Virgili) ; Rull, Anna (Universitat Rovira i Virgili) ; Girona, Josefa (Universitat Rovira i Virgili) ; Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ; Fuertes-Martín, Rocío (Universitat Rovira i Virgili) ; Amigó, Núria (Universitat Rovira i Virgili) ; Rodríguez-Borjabad, Cèlia (Universitat Rovira i Virgili) ; Martínez-Micaelo, Neus (Universitat Rovira i Virgili) ; Leal, Manuel (Viamed-Santa Ángela de la Cruz Hospital) ; Peraire, Joaquim (Universitat Rovira i Virgili) ; Correig, Xavier (Universitat Rovira i Virgili) ; Vidal, Francesc (Universitat Rovira i Virgili) ; Masana, Luisa (Universitat Rovira i Virgili) ; Universitat Autònoma de Barcelona
Plasma glycoproteins are a composite biomarker of inflammation and can be detected byH-NMR. The aim of this study was to prospectively appraise the clinical value of plasma glycopro-teins assessed byH-NMR in people living with HIV (PLWH). [...]
2020 - 10.3390/jcm9051344
Journal of clinical medicine, Vol. 9 Núm. 5 (may 2020) , p. 1344  
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19.
17 p, 2.4 MB CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice / Gutiérrez-Muñoz, C. (IIS-Hospital Universitario Fundación Jiménez Díaz) ; Méndez-Barbero, N. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Svendsen, P. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Sastre, C. (Massachusetts General Hospital) ; Fernández-Laso, V. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Quesada, P. (IIS-Hospital Universitario Fundación Jiménez Díaz) ; Egido, J. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas (CIBERDEM)) ; Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ; Martín-Ventura, J.L. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Moestrup, S.K. (Aarhus University) ; Blanco-Colio, Luis Miguel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Atherosclerosis is an inflammatory disease characterized by the accumulation of macrophages in the vessel wall. Macrophages depend on their polarization to exert either pro-inflammatory or anti-inflammatory effects. [...]
2020 - 10.1096/fj.202000177R
FASEB Journal, Vol. 34 Núm. 11 (january 2020) , p. 14960-14976  
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20.
26 p, 1.5 MB Novel Therapeutic Approaches to Prevent Atherothrombotic Ischemic Stroke in Patients with Carotid Atherosclerosis / Puig Grifol, Núria (Institut d'Investigació Biomèdica Sant Pau) ; Solé, Arnau (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Aguilera-Simón, Ana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Griñán, Raquel (Institut d'Investigació Biomèdica Sant Pau) ; Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau) ; Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ; Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Atherothrombotic stroke represents approximately 20% of all ischemic strokes. It is caused by large-artery atherosclerosis, mostly in the internal carotid artery, and it is associated with a high risk of early recurrence. [...]
2023 - 10.3390/ijms241814325
International journal of molecular sciences, Vol. 24 (september 2023)  
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