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Articles 25 records found  previous11 - 20next  jump to record: Search took 0.00 seconds. 
11.
11 p, 4.9 MB Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations / Perini, D. Aurora (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I) ; Aguilella-Arzo, Marcel (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I) ; Alcaraz, Antonio (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I) ; Perálvarez-Marín, Alex (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Queralt-Martín, María (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I)
Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. [...]
2021 - 10.1016/j.csbj.2021.12.021
Computational and Structural Biotechnology Journal, Vol. 20 (december 2021) , p. 230-240  
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12.
10 p, 1.4 MB Metal utilization in genome-reduced bacteria : Do human mycoplasmas rely on iron? / Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Baranowski, Eric (Université de Toulouse. Interactions Hôtes-Agents Pathogènes) ; Bierge, Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Quijada Pich, Oscar (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lebrette, Hugo (Stockholm University. Department of Biochemistry and Biophysics) ; Universitat Autònoma de Barcelona. Institut de Neurociències
Mycoplasmas are parasitic bacteria with streamlined genomes and complex nutritional requirements. Although iron is vital for almost all organisms, its utilization by mycoplasmas is controversial. Despite its minimalist nature, mycoplasmas can survive and persist within the host, where iron availability is rigorously restricted through nutritional immunity. [...]
2021 - 10.1016/j.csbj.2021.10.022
Computational and Structural Biotechnology Journal, Vol. 19 (2021) , p. 5752-5761  
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13.
16 p, 2.0 MB ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit / Lamy, Anaïs (Umeå University) ; Macarini-Bruzaferro, Ewerton (University of São Paulo) ; Dieudonné, Thibaud (Aarhus University) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Facultat de Medicina) ; Lenoir, Guillaume (Université Paris-Saclay, CEA, CNRS) ; Montigny, Cédric (Université Paris-Saclay, CEA, CNRS) ; le Maire, Marc (Université Paris-Saclay, CEA, CNRS) ; Vázquez-Ibar, José Luis (Université Paris-Saclay, CEA, CNRS)
Gene targeting approaches have demonstrated the essential role for the malaria parasite of membrane transport proteins involved in lipid transport and in the maintenance of membrane lipid asymmetry, representing emerging oportunites for therapeutical intervention. [...]
2021 - 10.1080/22221751.2020.1870413
Emerging microbes & infections, Vol. 10 (january 2021) , p. 132-147  
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14.
11 p, 1.4 MB Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1 / Ondono, Raul (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Lirio, Ángel (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Elvira, Carlos (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Provenzano, Claudia (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ; Cardinali, Beatrice (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ; Pérez-Alonso, Manuel (Universitat de València) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Borrell, José Ignacio (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Falcone, Germana (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ; Estrada-Tejedor, Roger (Universitat Ramon Llull. Institut Químic de Sarrià-IQS)
Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3' untranslated region (3'UTR). The intrinsic complexity and lack of crystallographic data makes noncoding RNA regions challenging targets to study in the field of drug discovery. [...]
2021 - 10.1016/j.csbj.2020.11.053
Computational and Structural Biotechnology Journal, Vol. 19 (2021) , p. 51-61  
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15.
14 p, 6.6 MB From Mouse To Human : Comparative Analysis Between Grey And White Matter By Synchrotron-Fourier Transformed Infrared Microspectroscopy / Sanchez-Molina, Paula (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valente, Tony (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kreuzer, Martin (ALBA Laboratori de Llum de Sincrotró) ; Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró)
Fourier Transform Infrared microspectroscopy (μFTIR) is a very useful method to analyze the biochemical properties of biological samples in situ. Many diseases affecting the central nervous system (CNS) have been studied using this method, to elucidate alterations in lipid oxidation or protein aggregation, among others. [...]
2020 - 10.3390/biom10081099
Biomolecules, Vol. 10, Núm. 8 (August 2020) , art. 1099  
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16.
16 p, 21.0 MB Transcriptional response to metal starvation in the emerging pathogen Mycoplasma genitalium is mediated by Fur-dependent and -independent regulatory pathways / Martínez Torró, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Torres Puig, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Monge, Marta (Vall d'Hebron Institut d'Oncologia) ; Sánchez Alba, Lucía (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Martín, Miguel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcos Silva, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Canals, Francesc (Vall d'Hebron Institut d'Oncologia) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Quijada Pich, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Transition metals participate in numerous enzymatic reactions and they are essential for survival in all living organisms. For this reason, bacterial pathogens have evolved dedicated machineries to effectively compete with their hosts and scavenge metals at the site of infection. [...]
2020 - 10.1080/22221751.2019.1700762
Emerging microbes & infections, Vol. 9, issue 1 (Jan. 2020) , p. 5-19  
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17.
11 p, 2.1 MB Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris / Suades, Albert (Stockholm University. Department of Biochemistry and Biophysics) ; Alcaraz, Antonio (Universitat Jaume I. Departament de Física) ; Cruz, Esteban (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Whitelegge, Julian P. (David Geffen School of Medicine) ; Manyosa Ribatallada, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Heterologous expression of human membrane proteins is a challenge in structural biology towards drug discovery. Here we report a complete expression and purification process of a functional human sodium/D-glucose co-transporter 1 (hSGLT1) in Pichia pastoris as representative example of a useful strategy for any human membrane protein. [...]
2019 - 10.1038/s41598-018-37445-2
Scientific reports, Vol. 9 (February 2019) , art. 1203  
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18.
9 p, 632.8 KB Human Albumin Impairs Amyloid β-peptide Fibrillation Through its C-terminus : From docking Modeling to Protection Against Neurotoxicity in Alzheimer's disease / Picón-Pagès, Pol (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Bonet, Jaume (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ; García-García, Javier (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ; Garcia-Buendia, Joan (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Gutiérrez, Daniela (Pontificia Universidad Católica de Chile. Departamento de Biología Celular y Molecular) ; Valle García, Javier (Universitat Pompeu Fabra. Grup de Recerca en Proteòmica i Química de Proteïnes) ; Gómez-Casuso, Carmen E. S. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Sidelkivska, Valeriya (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Alvarez, Alejandra (Pontificia Universidad Católica de Chile. Departamento de Biología Celular y Molecular) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Suades, Albert (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fernàndez-Busquets, Xavier (Barcelona Institute for Global Health (ISGlobal)) ; Andreu Martínez, David (Universitat Pompeu Fabra. Grup de Recerca en Proteòmica i Química de Proteïnes) ; Vicente, Rubén (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ; Muñoz, Francisco J. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular)
Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate into β-sheets that are neurotoxic. [...]
2019 - 10.1016/j.csbj.2019.06.017
Computational and Structural Biotechnology Journal, Vol. 17 (2019) , p. 963-971  
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19.
11 p, 2.2 MB The membrane proximal domain of TRPV1 and TRPV2 channels mediates protein-protein interactions and lipid binding in vitro / Doñate-Macian, Pablo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sepulcre, Francesc (Universitat Politècnica de Catalunya. Departament d'Enginyeria Agroalimentària i Biotecnologia) ; Vázquez Ibar, José Luis (Institut des Sciences du Vivant Frédéric-JOLIOT. CEA-Saclay) ; Perálvarez Marín, Alex (Universitat de Barcelona. Institut de Neurociències)
Constitutive or regulated membrane protein trafficking is a key cell biology process. Transient receptor potential channels are somatosensory proteins in charge of detecting several physical and chemical stimuli, thus requiring fine vesicular trafficking. [...]
2019 - 10.3390/ijms20030682
International journal of molecular sciences, Vol. 20, Issue 3 (February 2019) , art. 682  
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20.
13 p, 2.1 MB Peptide Assembly on the Membrane Determines the HIV-1 Inhibitory Activity of Dual-Targeting Fusion Inhibitor Peptides / Gómara Elena, María José (Institut de Química Avançada de Catalunya) ; Pérez, Yolanda (Institut de Química Avançada de Catalunya) ; Martinez, Javier P. (Universitat Pompeu Fabra) ; Barnadas Rodríguez, Ramon (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Schultz, Anke (Fraunhofer Institute for Biomedical Engineering (Sulzbach, Alemanya)) ; von Briesen, Hagen (Fraunhofer Institute for Biomedical Engineering (Sulzbach, Alemanya)) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Meyerhans, Andreas (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Haro, Isabel (Institut de Química Avançada de Catalunya)
Novel strategies in the design of HIV-I fusion/entry inhibitors are based on the construction of dual- targeting fusion proteins and peptides with synergistic antiviral effects. In this work we describe the design of dual -targeting peptides composed of peptide domains of E2 and El envelope proteins from Human Pegivirus with the aim of targeting both the loop region and the fusion peptide domains of HIV-I gp41. [...]
2019 - 10.1038/s41598-019-40125-4
Scientific reports, Vol. 9 (2019) , art. 3257  
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