Articles

Articles 109 records found  beginprevious18 - 27nextend  jump to record: Search took 0.02 seconds. 
18.
18 p, 2.3 MB Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes / Pfrengle, Saskia (University of Tübingen. Institute of Evolutionary Medicine) ; Neukamm, Judith (University of Tübingen. Institute for Archaeological Sciences) ; Guellil, Meriam (University of Tartu. Estonian Biocentre, Institute of Genomics) ; Keller, Marcel (University of Tartu. Institute of Genomics) ; Molak, Martyna (University of Warsaw. Centre of New Technologies) ; Avanzi, Charlotte (Colorado State University. Department of Microbiology, Immunology and Pathology) ; Kushniarevich, Alena (University of Tartu. Institute of Genomics) ; Montes, Núria (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Neumann, Gunnar U. (Max Planck Institute for the Science of Human History) ; Reiter, Ella (University of Tübingen. Institute for Archaeological Sciences) ; Tukhbatova, Rezeda I. (Max Planck Institute for the Science of Human History) ; Berezina, Nataliya Y. (Moscow State University. Research Institute and Museum of Anthropology) ; Buzhilova, Alexandra P. (Moscow State University. Research Institute and Museum of Anthropology) ; Korobov, Dmitry S. (Russian Academy of Sciences. Institute of Archaeology) ; Suppersberger Hamre, Stian (University of Bergen. Department of Archaeology, History, Cultural studies and religion) ; Matos, Vitor M. J. (University of Coimbra. Department of Life Sciences) ; Ferreira, Maria T. (Universidad de León. Departamento de Biodiversidad y Gestión Ambiental) ; González-Garrido, Laura (Universidad de León. Departamento de Biodiversidad y Gestión Ambiental) ; Wasterlain, Sofia N. (University of Coimbra. Department of Life Sciences) ; Lopes, Célia (University of Coimbra. Department of Life Sciences) ; Santos, Ana Luisa (University of Coimbra. Department of Life Sciences) ; Antunes-Ferreira, Nathalie (Instituto Universitário Egas Moniz) ; Duarte, Vitória (University of Coimbra. Department of Life Sciences) ; Silva, Ana Maria (University of Coimbra. Department of Life Sciences) ; Melo, Linda (University of Coimbra. Department of Life Sciences) ; Sarkic, Natasa (OSTEO Research) ; Saag, Lehti (University of Tartu. Institute of Genomics) ; Tambets, Kristiina (University of Tartu. Institute of Genomics) ; Busso, Philippe (Ecole Polytechnique Fédérale de Lausanne. Global Health Institute) ; Cole, Stewart T. (Ecole Polytechnique Fédérale de Lausanne. Global Health Institute) ; Avlasovich, Alexei (Mogilev State A. Kuleshov University. Department of Archeology, History of Belarus and Special Historical Disciplines) ; Roberts, Charlotte A. (Durham University. Department of Archaeology) ; Sheridan, Alison (National Museums Scotland. Department of Scottish History and Archaeology) ; Cessford, Craig (University of Cambridge. Department of Archaeology) ; Robb, John (University of Cambridge. Department of Archaeology) ; Krause, Johannes (University of Tübingen. Institute for Archaeological Sciences) ; Scheib, Christiana L. (University of Cambridge. St John's College) ; Inskip, Sarah A. (University of Leicester. School of Archaeology and Ancient History) ; Schuenemann, Verena J. (University of Tübingen. Senckenberg Centre for Human Evolution and Paleoenvironments)
Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. [...]
2021 - 10.1186/s12915-021-01120-2
BMC biology, Vol. 19 (2021) , art. 220  
19.
10 p, 2.4 MB Spatial genetic structure of European wild boar, with inferences on late-Pleistocene and Holocene demographic history / de Jong, Joost F. (Wageningen University. Wildlife Ecology & Conservation Group) ; Iacolina, Laura (University of Primorska. Faculty of Mathematics, Natural Sciences and Information Technologies) ; Prins, Herbert H. T. (Wageningen University. Animal Sciences Group) ; van Hooft, Pim (Wageningen University. Wildlife Ecology & Conservation Group) ; Crooijmans, Richard (Wageningen University. Animal Breeding and Genomics Group) ; van Wieren, Sip E. (Wageningen University. Wildlife Ecology & Conservation Group) ; Baños, Joaquin Vicente (Instituto de Investigación en Recursos Cinegéticos) ; Baubet, Eric (Office Français pour la Biodiversité) ; Cahill, Sean (Consorci del Parc Natural de la Serra de Collserola. Estació Biològica de Can Balasc) ; Ferreira, Eduardo (University of Aveiro. Department of Biology & CESAM - Centre for Environmental and Marine Studies) ; Fonseca, Carlos (University of Aveiro. Department of Biology & CESAM - Centre for Environmental and Marine Studies) ; Glazov, Peter M. (Russian Academy of Sciences. Institute of Geography) ; Jelenko Turinek, Ida (Ministry of Environment and Spatial Planning) ; Lizana, Victor (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ; Náhlik, András (Sapientia Hungarian University of Transylvania) ; Pokorny, Boštjan (Slovenian Forestry Institute) ; Podgórski, Tomasz (Czech University of Life Sciences. Department of Game Management and Wildlife Biology) ; Sprem, Nikica (University of Zagreb. Department of Fisheries, Apiculture, Wildlife Management and Special Zoology) ; Veeroja, Rauno (Estonian Environment Agency) ; Ydenberg, Ronald C. (Simon Fraser University. Centre of Wildlife Ecology) ; Megens, Hendrik-Jan (Wageningen University. Animal Breeding and Genomics Group)
European wildlife has been subjected to intensifying levels of anthropogenic impact throughout the Holocene, yet the main genetic partitioning of many species is thought to still reflect the late-Pleistocene glacial refugia. [...]
2023 - 10.1038/s41437-022-00587-1
Heredity, Vol. 130 (january 2023) , p. 135-144  
20.
48 p, 1.7 MB The diversity of primates : from biomedicine to conservation genomics / Orkin, Joseph D. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Kuderna, Lukas F.K. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Until now, the field of primate genomics has focused on two major themes: understanding human evolution and advancing biomedical research. We propose that it is now time for a third theme to receive attention: conservation genomics. [...]
2021 - 10.1146/annurev-animal-061220-023138
Annual Review of Animal Biosciences, Vol. 9 (February 2021) , p. 103-124  
21.
21 p, 1.3 MB Predictive Biomarkers of Oxaliplatin-Induced Peripheral Neurotoxicity / Velasco, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Alemany, Montserrat (Institut d'Investigació Biomèdica de Bellvitge) ; Villagrán, Macarena (Institut d'Investigació Biomèdica de Bellvitge) ; Argyriou, Andreas A. (Neurology Department, "Saint Andrew's" State General Hospital of Patras)
Oxaliplatin (OXA) is a platinum compound primarily used in the treatment of gastrointestinal cancer. OXA-induced peripheral neurotoxicity (OXAIPN) is the major non-hematological dose-limiting toxicity of OXA-based chemotherapy and includes acute transient neurotoxic effects that appear soon after OXA infusion, and chronic non-length dependent sensory neuronopathy symmetrically affecting both upper and lower limbs in a stocking-and-glove distribution. [...]
2021 - 10.3390/jpm11070669
Journal of Personalized Medicine, Vol. 11 (july 2021)  
22.
7 p, 675.0 KB Somatic genetic variation in healthy tissue and non-cancer diseases / Solís-Moruno, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Batlle-Masó, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bonet, Núria (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Aróstegui, Juan Ignacio (Universitat de Barcelona) ; Casals, Ferran (Universitat de Barcelona. Institut de Biomedicina) ; Universitat Autònoma de Barcelona
Somatic genetic variants have been studied for several years mostly concerning cancer, where they contribute to its origin and development. It is also clear that the somatic variants load is greater in aged individuals in comparison to younger ones, pointing to a cause/consequence of the senescence process. [...]
2022 - 10.1038/s41431-022-01213-8
European Journal of Human Genetics, Vol. 31 (october 2022) , p. 48-54  
23.
17 p, 1.4 MB Early T-Cell Precursor ALL and Beyond : Immature and Ambiguous Lineage T-ALL Subsets / Genescà, Eulàlia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Starza, Roberta la (Università degli Studi di Perugia)
A wide range of immature acute leukemias (AL), ranging from acute myeloid leukemias with minimal differentiation to acute leukemias with an ambiguous lineage, i. e. , acute undifferentiated leukemias and mixed phenotype acute leukemia with T-or B-plus myeloid markers, cannot be definitely assigned to a single cell lineage. [...]
2022 - 10.3390/cancers14081873
Cancers, Vol. 14 Núm. 8 (4-2 2022) , p. 1873  
24.
17 p, 5.1 MB Robust temporal map of human in vitro myelopoiesis using single-cell genomics / Alsinet, Clara (Open Targets. Wellcome Genome Campus) ; Primo, Maria Nascimento (Open Targets. Wellcome Genome Campus) ; Lorenzi, Valentina (Wellcome Sanger Institute. Wellcome Genome Campus) ; Bello, Erica (Open Targets. Wellcome Genome Campus) ; Kelava, Iva (Wellcome Sanger Institute. Wellcome Genome Campus) ; Jones, Carla P. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Vilarrasa Blasi, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ; Sancho Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ; Knights, Andrew J. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Park, Jong Eun (Korea Advanced Institute of Science and Technology) ; Wyspianska, Beata S. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ; Trynka, Gosia (Open Targets. Wellcome Genome Campus) ; Tough, David F. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ; Bassett, Andrew (Open Targets. Wellcome Genome Campus) ; Gaffney, Daniel J. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vento Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus)
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis protocols is imperative for their use in research, immunotherapies, and understanding human myelopoiesis. Here, we generate a >470K cells molecular map of human induced pluripotent stem cells (iPSC) differentiation into macrophages. [...]
2022 - 10.1038/s41467-022-30557-4
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2885  
25.
11 p, 2.6 MB Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA / Sánchez, Ricardo (Hospital Universitario 12 de Octubre (Madrid)) ; Dorado, Sara (Universidad Carlos III de Madrid. Departamento de Informática e Ingeniería) ; Ruíz-Heredia, Yanira (Altum Sequencing (Madrid)) ; Martín-Muñoz, Alejandro (Altum Sequencing (Madrid)) ; Rosa-Rosa, J.M. (Unidad de Investigación Clínica de Neoplasias Hematológicas (Madrid)) ; Ribera Salas, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Jimenez-Ubieto, Ana (Unidad de Investigación Clínica de Neoplasias Hematológicas (Madrid)) ; Carreño-Tarragona, Gonzalo (Unidad de Investigación Clínica de Neoplasias Hematológicas (Madrid)) ; Linares, Maria (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Rufián, Laura (Altum Sequencing (Madrid)) ; Juárez, Alexandra (Altum Sequencing (Madrid)) ; Carrillo García, Jaime (Altum Sequencing (Madrid)) ; Espino, María José (Hospital Universitario 12 de Octubre (Madrid)) ; Cáceres, Mercedes (Hospital Universitario 12 de Octubre (Madrid)) ; Expósito, Sara (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Cuevas, Beatriz (Hospital Universitario de Burgos) ; Vanegas, Raúl (Hospital General Universitario de Ciudad Real) ; Casado Montero, Luis Felipe (Hospital Virgen de la Salud (Toledo)) ; Torrent Catarineu, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Mercadal, Santiago (Hospital Duran i Reynals (Barcelona)) ; Coll, Rosa (Hospital Universitari de Girona Doctor Josep Trueta) ; Cervera, Marta (Hospital Universitari Joan XXIII de Tarragona) ; Morgades, Mireia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hernández-Rivas, José Angel (Hospital Universitario Infanta Leonor) ; Bravo, Pilar (Hospital Universitario de Fuenlabrada ( Madrid)) ; Serí, Cristina (Hospital Central de la Defensa Gómez Ulla) ; Anguita, Eduardo (Hospital Clínico San Carlos (Madrid)) ; Barragán, Eva (Hospital Universitari i Politècnic La Fe (València)) ; Sargas, Claudia (Hospital Universitari i Politècnic La Fe (València)) ; Ferrer-Marín, Francisco (Hospital General Universitario Morales Meseguer (Múrcia)) ; Sánchez-Calero, Jorge (Hospital Universitario de Móstoles (Madrid)) ; Sevilla, Julián (Hospital Infantil Universitario Niño Jesús (Madrid)) ; Ruíz, Elena (Hospital del Tajo) ; Villalón, Lucía (Hospital Universitario Fundación Alcorcón) ; Herráez, María del Mar (Hospital Santa Bárbara) ; Riaza, Rosalía (Hospital Universitario Severo Ochoa) ; Magro, Elena (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid)) ; Steegman, Juan Luís (Hospital Universitario de la Princesa (Madrid)) ; Wang, Chongwu (Hosea Precision Medical Technology (Xina)) ; de Toledo, Paula (Universidad Carlos III de Madrid. Departamento de Informática e Ingeniería) ; García-Gutiérrez, Valentín (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Ayala, Rosa (Centro de Investigación Biomédica en Red de Cáncer) ; Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Barrio, Santiago (Altum Sequencing (Madrid)) ; Martínez-López, Joaquín (Centro de Investigación Biomédica en Red de Cáncer) ; Universitat Autònoma de Barcelona
The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. [...]
2022 - 10.1038/s41598-022-17271-3
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 13057  
26.
10 p, 1012.4 KB Unravelling the genetics of non-random fertilization associated with gametic incompatibility / Martin, Audrey A. A. (University of Guelph. Centre for Genetic Improvement of Livestock) ; Id-Lahoucine, Samir (Scotland's Rural College. Department of Animal and Veterinary Sciences) ; Fonseca, Pablo A. S. (University of Guelph. Centre for Genetic Improvement of Livestock) ; Rochus, Christina M. (University of Guelph. Centre for Genetic Improvement of Livestock) ; Alcantara, Lucas M. (University of Guelph. Centre for Genetic Improvement of Livestock) ; Tulpan, Dan (University of Guelph. Centre for Genetic Improvement of Livestock) ; LeBlanc, Stephen J. (Ontario Veterinary College, University of Guelph) ; Miglior, Filippo (University of Guelph. Centre for Genetic Improvement of Livestock) ; Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Cánovas, Angela (University of Guelph. Centre for Genetic Improvement of Livestock) ; Baes, Christine F. (University of Bern. Institute of Genetics, Vetsuisse Faculty) ; Schenkel, Flavio S. (University of Guelph. Centre for Genetic Improvement of Livestock)
In the dairy industry, mate allocation is dependent on the producer's breeding goals and the parents' breeding values. The probability of pregnancy differs among sire-dam combinations, and the compatibility of a pair may vary due to the combination of gametic haplotypes. [...]
2022 - 10.1038/s41598-022-26910-8
Scientific reports, Vol. 12 (december 2022)  
27.
19 p, 3.3 MB Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers / Shah, Jennifer B. (University of Pennsylvania) ; Pueschl, Dana (University of Pennsylvania) ; Wubbenhorst, Bradley (University of Pennsylvania) ; Fan, Mengyao (University of Pennsylvania) ; Pluta, John (University of Pennsylvania) ; D'Andrea, Kurt (University of Pennsylvania) ; Hubert, Anna P. (University of Pennsylvania) ; Shilan, Jake S. (University of Pennsylvania) ; Zhou, Wenting (University of Pennsylvania) ; Kraya, Adam A. (University of Pennsylvania) ; Llop Guevara, Alba (Vall d'Hebron Institut d'Oncologia) ; Ruan, Catherine (University of Pennsylvania. Perelman School of Medicine) ; Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ; Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ; Feldman, Michael (University of Pennsylvania) ; Morin, Pat J. (University of Pennsylvania) ; Nayak, Anupma (University of Pennsylvania) ; Maxwell, Kara N. (University of Pennsylvania) ; Domchek, Susan M. (University of Pennsylvania) ; Nathanson, Katherine L. (University of Pennsylvania) ; Universitat Autònoma de Barcelona
Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). Herein we perform multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify potential recurrence-specific drivers. [...]
2022 - 10.1038/s41467-022-34523-y
Nature communications, Vol. 13 (november 2022)  

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