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455.
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15 p, 797.9 KB |
The GRADE Evidence to Decision (EtD) framework for health system and public health decisions
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Moberg, Jenny (Norwegian Institute of Public Health) ;
Oxman, Andrew D. (Norwegian Institute of Public Health) ;
Rosenbaum, Sarah (Norwegian Institute of Public Health) ;
Schünemann, Holger J. (McMaster University (Canadà)) ;
Guyatt, Gordon (McMaster University (Canadà)) ;
Flottorp, Signe (Norwegian Institute of Public Health) ;
Glenton, Claire (Norwegian Institute of Public Health) ;
Lewin, Simon (South African Medical Research Council) ;
Morelli, Angela (Norwegian Institute of Public Health) ;
Rada, Gabriel (Pontificia Universidad Católica de Chile) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
To describe a framework for people making and using evidence-informed health system and public health recommendations and decisions. We developed the GRADE Evidence to Decision (EtD) framework for health system and public health decisions as part of the DECIDE project, in which we simultaneously developed frameworks for these and other types of healthcare decisions, including clinical recommendations, coverage decisions and decisions about diagnostic tests. [...]
2018 -  10.1186/s12961-018-0320-2
Health Research Policy and Systems, Vol. 16 Núm. 1 (29 2018) , p. 45
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456.
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8 p, 667.2 KB |
Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia
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Philtjens, Stéphanie (University of Antwerp) ;
Van Mossevelde, Sara (Antwerp University Hospital (UZA)) ;
Van der Zee, Julie (University of Antwerp) ;
Wauters, Eline (University of Antwerp) ;
Dillen, Lubina (University of Antwerp) ;
Vandenbulcke, Mathieu (University Hospitals Leuven (Bèlgica)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Ivanoiu, Adrian (Université Catholique de Louvain) ;
Sieben, Anne (Universitair Ziekenhuis Gent) ;
Willems, Christiana (Jessa Hospital) ;
Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Borroni, Barbara (University of Brescia) ;
Padovani, Alessandro (University of Brescia) ;
Pastor, Pau (Instituto de Salud Carlos III) ;
Diez-Fairen, Monica (Instituto de Salud Carlos III) ;
Aguilar, Miquel (Instituto de Salud Carlos III) ;
de Mendonça, Alexandre (University of Lisbon) ;
Miltenberger-Miltényi, Gabriel (University of Lisbon) ;
Hernández, Isabel (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Boada, M. (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Ruiz, A. (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Nacmias, B. (University of Florence) ;
Sorbi, S. (IRCCS Don Gnocchi) ;
Almeida, M.Rosario (University of Coimbra) ;
Santana, Isabel (University of Coimbra) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Frisoni, Giovanni B. (IRCCS Fatebenefratelli) ;
Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Llado Plarrumani, Albert (Hospital Clínic i Provincial de Barcelona) ;
Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ;
Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Van den Broeck, Marleen (University of Antwerp) ;
Peeters, Karin (University of Antwerp) ;
Cras, Patrick (Antwerp University Hospital (UZA)) ;
De Deyn, Peter P. (Middelheim and Hoge Beuken) ;
Engelborghs, Sebastiaan (Middelheim and Hoge Beuken) ;
Cruts, Marc (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Universitat Autònoma de Barcelona
We investigated the genetic role of sortilin (SORT1) in frontotemporal dementia (FTD). SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited FTD. [...]
2018 - 10.1016/j.neurobiolaging.2018.02.011
Neurobiology of Aging, Vol. 66 (june 2018) , p. 181.e3-181.e10
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457.
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7 p, 715.4 KB |
Safety and efficacy of self-administered inhaled loxapine (ADASUVE) in agitated patients outside the hospital setting : Protocol for a phase IV, single-arm, open-label trial
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Gil, Emilio (Ferrer Internacional. S.A.) ;
Garcia-Alonso, Fernando (Ferrer Internacional. S.A.) ;
Boldeanu, Anca (Ferrer Internacional. S.A.) ;
Baleeiro Teixeira, Thaïs (Ferrer Internacional. S.A.) ;
Tordera, Vicente (Hospital Lluís Alcanyis) ;
Viciedo, Ramón Palmer (Hospital Provincial de Castelló) ;
Salgado Serrano, Dr Purificación (Hospital del Mar (Barcelona, Catalunya)) ;
Domingo Ribas, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau) ;
Montes, José Manuel (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lauffer, Javier Correas (Hospital Univ de Henares) ;
Murugarrem, Salvador Ruiz (Hospital Príncipe de Asturias) ;
García, Santiago Ovejero (Hospital Universitario Fundación Jiménez Díaz) ;
Mora, Fernando (Hospital Universitario Infanta Leonor) ;
López, Presentación Ataz (Complejo Hospitalario Torrecárdenas (Almeria)) ;
Navas, Andrés Fontalba (Hospital la Inmaculada) ;
Pinto, Ana Mª González (Hospital Santiago Apóstol) ;
Martínez, Ricardo (Hospital Virgen Del Mirón) ;
Castrillo, César García (Complejo Hospitalario de Jaen) ;
Toledo, Francisco (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona) ;
González, Emilio (Hermanas Hospitalarias Sociosanitario Palencia) ;
Franco Martín, Manuel (Complejo Asistencial Zamora) ;
Drasovean, Nicolae Virgil (Spitalul de Psihiatrie 'Elisabeta Doamna' Galati) ;
Dahl, Nils Hâvard (Helse Nord-Trøndelag HV Sykehuset Levanger) ;
Skagen, Bo (Spesialistesenteret På Straume-Helsesenteret) ;
Zilles, David (Klinik Für Psychiatrie und Psychotherapie der Universitätsmedizin Göttingen) ;
Zwanzger, Peter (Allgemeinpsychiatrie und Psychosomatik) ;
Juckel, Georg (LWL-Universitätsklinikum Bochum der Ruhr-Universität Bochum) ;
Kahl, Kai G. (Medizinische Hochschule Hannover) ;
Messer, Thomas (Fachklinik Für Psychiatrie) ;
Kasper, Siegfried (Medizinische Universität Wien Universitätsklinik Für Psychiatrie und Psychotherapie) ;
Universitat Autònoma de Barcelona
There is a need for fast-acting, non-injection antiagitation treatments that are well tolerated and can be used outside of healthcare facilities. In phase II/III trials, an inhaled formulation of loxapine (ADASUVE®), a well-established, first-generation antipsychotic agent, provided rapid control of mild to moderate agitation in the hospital setting. [...]
2018 - 10.1136/bmjopen-2017-020242
BMJ open, Vol. 8 Núm. 10 (january 2018) , p. e020242
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458.
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8 p, 562.2 KB |
Updated performance of the Micra transcatheter pacemaker in the real-world setting : A comparison to the investigational study and a transvenous historical control
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El-Chami, Mikhael F. (Emory University) ;
Al-Samadi, Faisal (King Salman Heart Center - King Fahad Medical City) ;
Clementy, Nicolas (Centre Hospitalier Régional Universitaire de Tours - Hôpital Trousseau) ;
Garweg, Christophe (Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg) ;
Martinez-Sande, Jose Luis (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Piccini, Jonathan P. (Duke University Medical Center) ;
Iacopino, Saverio (Maria Cecelia Hospital) ;
Lloyd, Michael (Emory University) ;
Viñolas, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Jacobsen, Michael Dilou (University of Copenhagen) ;
Ritter, Philippe (Université Bordeaux) ;
Johansen, Jens Brock (Odense University Hospital (Dinamarca)) ;
Tondo, Claudio (University of Milan) ;
Liu, Fang (Medtronic. plc) ;
Fagan, Dedra H. (Medtronic. plc) ;
Eakley, Alyssa K. (Medtronic. plc) ;
Roberts, Paul R. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Universitat Autònoma de Barcelona
Early results of the Micra Investigational Device Exemption (IDE) study and Micra Post-Approval Registry (PAR) demonstrated excellent safety and efficacy performance; however, intermediate-term results across a large patient population in the real-world setting have not been evaluated. [...]
2018 - 10.1016/j.hrthm.2018.08.005
Heart Rhythm, Vol. 15 Núm. 12 (december 2018) , p. 1800-1807
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459.
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20 p, 846.7 KB |
Moderate beer intake and cardiovascular health in overweight individuals
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Padró, Teresa (Institut d'Investigació Bomèdica Sant Pau) ;
Muñoz-García, Natàlia (Institut d'Investigació Biomèdica Sant Pau) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Chagas, Patricia (Universidade Federal de Santa Maria) ;
Deyà, Alba (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Antonijoan Arbós, Rosa Ma (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Consistent epidemiological evidence indicates that low-to-moderate alcohol consumption is inversely associated with cardiovascular event presentation, while high levels of alcohol intake are associated to increased cardiovascular risk. [...]
2018 - 10.3390/nu10091237
Nutrients, Vol. 10 Núm. 9 (may 2018) , p. 1237
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460.
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9 p, 501.6 KB |
Socioeconomic inequalities in health and the use of healthcare services in Catalonia : Analysis of the individual data of 7.5 million residents
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García-Altés, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Ruiz-Munõz, Dolores (Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS)) ;
Colls, Cristina (Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS)) ;
Mias, Montse (Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS)) ;
Martín Bassols, Nicolau (Monash Business School) ;
Universitat Autònoma de Barcelona
The aim of this study is to analyse the health status, the use of public healthcare services and the consumption of prescription drugs in the population of Catalonia, taking into consideration the socioeconomic level of individuals and paying special attention to vulnerable groups. [...]
2018 - 10.1136/jech-2018-210817
Journal of Epidemiology and Community Health, Vol. 72 Núm. 10 (january 2018) , p. 871-879
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461.
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10 p, 598.4 KB |
Values and preferences of men for undergoing prostate-specific antigen screening for prostate cancer : a systematic review
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Vernooij, Robin W.M. (Netherlands Comprehensive Cancer Organisation) ;
Lytvyn, Lyubov (McMaster University (Canadà)) ;
Pardo-Hernandez, Hector (Institut d'Investigació Biomèdica Sant Pau) ;
Albarqouni, Loai (Bond University) ;
Canelo Aybar, Carlos Gilberto (Universidad Peruana de Ciencias Aplicadas) ;
Campbell, Karen (McMaster University (Canadà)) ;
Agoritsas, Thomas (Geneva University Hospitals) ;
Universitat Autònoma de Barcelona
To investigate men's values and preferences regarding prostate-specific antigen (PSA)-based screening for prostate cancer. Systematic review. We searched MEDLINE, EMBASE, PsycINFO and grey literature up to 2 September 2017. [...]
2018 - 10.1136/bmjopen-2018-025470
BMJ open, Vol. 8 Núm. 9 (2018) , p. e025470
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462.
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463.
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19 p, 600.4 KB |
Improvement in Parameters of Hematologic and Immunologic Function and Patient Well-being in the Phase III RESONATE Study of Ibrutinib Versus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
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Barrientos, Jacqueline C. (Zucker School of Medicine at Hofstra/Northwell) ;
O'Brien, Susan (University of California Irvine) ;
Brown, Jennifer R. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Kay, Neil E. (Mayo Clinic) ;
Reddy, Nishitha M. (Vanderbilt-Ingram Cancer Center) ;
Coutre, Steven E (Stanford University School of Medicine) ;
Tam, Constantine (Peter MacCallum Cancer Centre and St Vincent's Hospital) ;
Mulligan, Stephen (Royal North Shore Hospital) ;
Jaeger, Ulrich (Medical University of Vienna) ;
Devereux, Stephen (King's College Hospital NHS Foundation Trust) ;
Pocock, Christopher (East Kent Hospitals University) ;
Robak, Tadeusz (Medical University of Lodz) ;
Schuster, Stephen J. (Perelman Center for Advanced Medicine) ;
Schuh, Anna (University of Oxford) ;
Gill, Devinder (Princess Alexandra Hospital) ;
Bloor, Adrian (The Christie Clinic) ;
Dearden, Claire (The Royal Marsden Hospital) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Cull, Gavin (Sir Charles Gardiner Hospital) ;
Hamblin, Mike (Colchester Hospital) ;
Jones, Jeffrey A. (The Ohio State University Comprehensive Cancer Center) ;
Eckert, Karl (Pharmacyclics LLC. an AbbVie Company) ;
Solman, Isabelle G. (Pharmacyclics LLC. an AbbVie Company) ;
Suzuki, Samuel (Pharmacyclics LLC. an AbbVie Company) ;
Hsu, Emily (Pharmacyclics LLC. an AbbVie Company) ;
James, Danelle F. (Pharmacyclics LLC. an AbbVie Company) ;
Byrd, John C. (The Ohio State University Comprehensive Cancer Center) ;
Hillmen, Peter (The Leeds Teaching Hospitals. St. James University Hospital) ;
Universitat Autònoma de Barcelona
In the phase III study RESONATE, ibrutinib reduced the risk of progression and improved overall survival versus ofatumumab in previously treated patients with CLL/SLL. In this novel analysis of patient well-being including patient-reported outcomes, ibrutinib reduced disease burden while preserving parameters of hematologic and immunologic function in RESONATE. [...]
2018 - 10.1016/j.clml.2018.08.007
Clinical Lymphoma, Myeloma & Leukemia, Vol. 18 Núm. 12 (december 2018) , p. 803-813.e7
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464.
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9 p, 1.3 MB |
Single-agent ibrutinib versus chemoimmunotherapy regimens for treatment-naïve patients with chronic lymphocytic leukemia : A cross-trial comparison of phase 3 studies
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Robak, Tadeusz (Medical University of Lodz) ;
Burger, Jan A. (The University of Texas MD Anderson Cancer Center) ;
Tedeschi, Alessandra (ASST Grande Ospedale Metropolitano Niguarda) ;
Barr, Paul M. (University of Rochester Cancer Center) ;
Owen, Carolyn (University of Calgary) ;
Bairey, Osnat (Tel Aviv University) ;
Hillmen, Peter (St. James's Institute of Oncology) ;
Simpson, David (North Shore Hospital) ;
Grosicki, Sebastian (Silesian Medical University) ;
Devereux, Stephen (King's College Hospital NHS Foundation Trust) ;
McCarthy, Helen (Royal Bournemouth Hospital) ;
Coutre, Steven E (Stanford University School of Medicine) ;
Quach, Hang (St. Vincent's Hospital) ;
Gaidano, Gianluca (Amedeo Avogadro University of Eastern Piedmont) ;
Maslyak, Zvenyslava (Institute of Blood Pathology and Transfusion Medicine of the Academy of Medical Sciences of Ukraine) ;
Stevens, Don A. (Norton Cancer Institute) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Gill, Devinder S. (Princess Alexandra Hospital) ;
Flinn, Ian W. (Sarah Cannon Research Institute/Tennessee Oncology) ;
Gribben, John G. (Queen Mary University of London) ;
Mokatrin, Ahmad (Pharmacyclics LLC. an AbbVie Company) ;
Cheng, Mei (Pharmacyclics LLC. an AbbVie Company) ;
Styles, Lori (Pharmacyclics LLC. an AbbVie Company) ;
James, Danelle F. (Pharmacyclics LLC. an AbbVie Company) ;
Kipps, Thomas J (University of California San Diego) ;
Ghia, Paolo (Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele) ;
Universitat Autònoma de Barcelona
Chemoimmunotherapy (CIT) and targeted therapy with single-agent ibrutinib are both recommended first-line treatments for chronic lymphocytic leukemia (CLL), although their outcomes have not been directly compared. [...]
2018 - 10.1002/ajh.25259
American Journal of Hematology, Vol. 93 Núm. 11 (november 2018) , p. 1402-1410
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