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581.
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14 p, 1.2 MB |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
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López-Isac, Elena (Institute of Parasitology and Biomedicine López-Neyra) ;
Acosta-Herrera, Marialbert (Institute of Parasitology and Biomedicine López-Neyra) ;
Kerick, Martin (Institute of Parasitology and Biomedicine López-Neyra) ;
Assassi, Shervin (The University of Texas Health Science Center-Houston) ;
Satpathy, Ansuman (Stanford University) ;
Granja, Jeffrey (Stanford University) ;
Mumbach, Maxwell (Stanford University) ;
Beretta, Lorenzo (Referral Center for Systemic Autoimmune Diseases) ;
Simeón-Aznar, Carmen Pilar (Hospital Universitari Vall d'Hebron) ;
Carreira, Patricia E. (Hospital Universitario 12 de Octubre) ;
Ortego-Centeno, Norberto (San Cecilio Clinic University Hospital) ;
Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Bossini-Castillo, Lara (Wellcome Trust Sanger Institute (Regne Unit)) ;
Carmona, F. David (Universidad de Granada) ;
Orozco, Gisela (The University of Manchester) ;
Hunzelmann, Nicolas (University of Cologne) ;
Distler, Jörg H. W. (University of Erlangen-Nuremberg) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Lunardi, Claudio (Università degli Studi di Verona) ;
Moroncini, Gianluca (Università Politecnica delle Marche and Ospedali Riuniti) ;
Gabrielli, Armando (Università Politecnica delle Marche and Ospedali Riuniti) ;
de Vries-Bouwstra, Jeska (Leiden University Medical Center) ;
Wijmenga, Cisca (University of Groningen) ;
Koeleman, Bobby (University Medical Center Utrecht) ;
Nordin, Annika (Karolinska Institutet (Estocolm, Suècia)) ;
Padyukov, Leonid (Karolinska Institutet (Estocolm, Suècia)) ;
Hoffmann-Vold, Anna-Maria (Oslo University Hospital) ;
Lie, Benedicte A. (University of Oslo and Oslo University Hospital) ;
Ríos, Raquel (San Cecilio Clinic University Hospital) ;
Callejas Rubio, Jose Luis (San Cecilio Clinic University Hospital) ;
Vargas-Hitos, José Antonio (Hospital Virgen de las Nieves (Granada, Andalusia)) ;
García-Portales, Rosa (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Camps, María Teresa (Carlos Haya Hospital) ;
Fernández-Nebro, Antonio (Carlos Haya Hospital) ;
González-Escribano, Maria Francisca (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García-Hernández, Francisco Jose (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Castillo, María Jesús (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Aguirre, Mª Angeles (Hospital Reina Sofía/IMIBIC) ;
Gómez-Gracia, Inmaculada (Hospital Reina Sofía/IMIBIC) ;
Fernández-Gutiérrez, B. (San Carlos Clinic Hospital) ;
Rodríguez-Rodríguez, L. (San Carlos Clinic Hospital) ;
García de la Peña, Paloma (Madrid Norte Sanchinarro Hospital) ;
Vicente-Rabaneda, Esther Francisca (Hospital Universitario de la Princesa (Madrid)) ;
Andréu, José Luis (Puerta de Hierro Hospital-Majadahonda) ;
Fernández de Castro, Mónica (Puerta de Hierro Hospital-Majadahonda) ;
López-Longo, Francisco Javier (Hospital General Universitario Gregorio Marañón) ;
Martínez, Lina Patricia (Hospital General Universitario Gregorio Marañón) ;
Fonollosa, Vicenç (Hospital Universitari Vall d'Hebron) ;
Guillén, Alfredo Chávez (Hospital Universitari Vall d'Hebron) ;
Espinosa, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Tolosa-Vilella, Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pros, Ana (Hospital del Mar (Barcelona, Catalunya)) ;
Rodríguez-Carballeira, M. (Hospital Universitari MútuaTerrassa) ;
Narváez, Francisco J. (Hospital Universitari de Bellvitge) ;
Rubio Rivas, Manuel (Hospital Universitari de Bellvitge) ;
Ortiz-Santamaría, None (Hospital Granollers) ;
Madroñero, A.B. (Hospital General Universitario San Jorge (Osca, Aragó)) ;
González-Gay, M.A. (Universidad de Cantabria) ;
Díaz, B. (Hospital Universitario Central de Asturias) ;
Trapiella, L. (Hospital Universitario Central de Asturias) ;
Sousa, A. (Hospital Xeral-Complexo Hospitalario Universitario de Vigo) ;
Egurbide, M.V. (Hospital Universitario Cruces) ;
Fanlo-Mateo, P. (Hospital Virgen del Camino (Pamplona)) ;
Sáez-Comet, L. (Hospital Universitario Miguel Servet (Saragossa)) ;
Díaz, F. (Hospital Universitario de Canarias) ;
Hernández, None (Hospital Universitario de Canarias) ;
Beltrán, E. (Hospital General Universitario de Valencia) ;
Román-Ivorra, J.A. (Hospital Universitari i Politècnic La Fe de València) ;
Grau, E. (Hospital Universitari i Politècnic La Fe de València) ;
Alegre-Sancho, Juan José (Hospital Universitari Doctor Peset) ;
Freire, M. (Complexo Hospitalario Universitario de Vigo) ;
Blanco-García, F.J (INIBIC-Hospital Universitario A Coruña) ;
Oreiro, N. (INIBIC-Hospital Universitario A Coruña) ;
Witte, T. (Hannover Medical School) ;
Kreuter, A. (Ruhr University Bochum) ;
Riemekasten, G. (University of Lübeck) ;
Airò, Paolo (Service of Rheumatology and Clinic Immunology Spedali Civili) ;
Magro-Checa, César (Leiden University Medical Center) ;
Voskuyl, A.E. (Amsterdam UMC. University Medical Center) ;
Vonk, Madelon C. (Radboud University Nijmegen Medical Center) ;
Hesselstrand, Roger (Lund University) ;
Proudman, Susanna (Royal Adelaide Hospital and University of Adelaide) ;
Stevens, Wendy (St. Vincent's Hospital) ;
Nikpour, Mandana (The University of Melbourne at St. Vincent's Hospital) ;
Zochling, Jane M. (University of Tasmania) ;
Sahhar, Joanne (Monash Medical Centre) ;
Roddy, Janet (Cincinnati Children's Hospital Medical Center (CCHMC). Center for Fetal and Placental Research) ;
Nash, Peter (Sunshine Coast Rheumatology) ;
Tymms, Kathleen (Canberra Rheumatology) ;
Rischmueller, Maureen (The Queen Elizabeth Hospital) ;
Lester, S. (The Queen Elizabeth Hospital) ;
Vyse, Timothy (King's College London) ;
Herrick, Ariane (NIHR Manchester Biomedical Research Centre) ;
Worthington, Jane (The University of Manchester) ;
Denton, Christopher P (Royal Free and University College Medical School) ;
Allanore, Yannick (Paris Descartes University) ;
Brown, Matthew A. (Princess Alexandra Hospital) ;
Radstake, Timothy R. D. J. (University Medical Center Utrecht) ;
Fonseca, Carmen (Royal Free and University College Medical School) ;
Chang, Howard Y. (Stanford University) ;
Mayes, Maureen D (The University of Texas Health Science Center-Houston) ;
Martín, Javier (Institute of Parasitology and Biomedicine López-Neyra) ;
Universitat Autònoma de Barcelona
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. [...]
2019 -  10.1038/s41467-019-12760-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4955
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582.
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25 p, 1.7 MB |
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours
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Hellquist, Henrik (University of Algarve) ;
Paiva-Correia, António (Manchester University NHS Foundation Trust) ;
Vander Poorten, Vincent (Multidisciplinary Salivary Gland Society) ;
Quer, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Hernandez-Prera, Juan C. (Moffitt Cancer Center) ;
Andreasen, Simon (Zealand University Hospital) ;
Zbären, Peter (University Hospital) ;
Skalova, Alena (Charles University) ;
Rinaldo, Alessandra (University of Udine School of Medicine) ;
Ferlito, Alfio (International Head and Neck Scientific Group) ;
Universitat Autònoma de Barcelona
A vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, for several reasons, this has not been the case in benign epithelial salivary gland tumours. [...]
2019 - 10.1007/s12325-019-01007-3
Advances in Therapy, Vol. 36 Núm. 8 (january 2019) , p. 1950-1974
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583.
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12 p, 1.3 MB |
Cediranib in patients with alveolar soft-part sarcoma (CASPS) : a double-blind, placebo-controlled, randomised, phase 2 trial
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Judson, Ian (The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust) ;
Morden, James P. (The Institute of Cancer Research) ;
Kilburn, Lucy (The Institute of Cancer Research) ;
Leahy, Michael (The Christie NHS Foundation Trust) ;
Benson, Charlotte (The Royal Marsden NHS Foundation Trust) ;
Bhadri, Vivek (Chris O'Brien Lifehouse) ;
Campbell-Hewson, Quentin (Newcastle upon Tyne Hospitals NHS Foundation Trust) ;
Cubedo, Ricardo (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Dangoor, Adam (University Hospitals Bristol NHS Foundation Trust) ;
Fox, Lisa (The Institute of Cancer Research) ;
Hennig, Ivo (Nottingham University Hospitals NHS Trust (Regne Unit)) ;
Jarman, Katy (The Institute of Cancer Research) ;
Joubert, Warren (Princess Alexandra Hospital) ;
Kernaghan, Sarah (The Institute of Cancer Research) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
McNeil, Catriona (Chris O'Brien Lifehouse) ;
Seddon, Beatrice (University College London Hospitals NHS Foundation Trust) ;
Snowdon, Claire (The Institute of Cancer Research) ;
Tattersall, Martin (Chris O'Brien Lifehouse) ;
Toms, Christy (The Institute of Cancer Research) ;
Martinez Trufero, Javier (Hospital Universitario Miguel Servet (Saragossa)) ;
Bliss, Judith M. (The Institute of Cancer Research) ;
Universitat Autònoma de Barcelona
Alveolar soft-part sarcoma (ASPS) is a rare soft-tissue sarcoma that is unresponsive to chemotherapy. Cediranib, a tyrosine-kinase inhibitor, has shown substantial activity in ASPS in non-randomised studies. [...]
2019 - 10.1016/S1470-2045(19)30215-3
The Lancet. Oncology, Vol. 20 Núm. 7 (july 2019) , p. 1023-1034
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584.
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12 p, 484.6 KB |
Safety profile of the adjuvanted recombinant zoster vaccine : Pooled analysis of two large randomised phase 3 trials
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López Fauqued, Marta (GlaxoSmithKline (GSK)) ;
Campora, Laura (GlaxoSmithKline (GSK)) ;
Delannois, Frédérique (GlaxoSmithKline (GSK)) ;
El Idrissi, Mohamed (GlaxoSmithKline (GSK)) ;
Oostvogels, Lidia (GlaxoSmithKline (GSK)) ;
De Looze, Ferdinandus (University of Queensland) ;
Diez-Domingo, Javier (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (València)) ;
Heineman, Thomas (GlaxoSmithKline (GSK)) ;
Lal, Himal (GlaxoSmithKline (GSK)) ;
McElhaney, Janet (Health Sciences North Research Institute) ;
McNeil, Shelly (Dalhousie University) ;
Yeo, Wilfred (University of Wollongong) ;
Tavares-Da-Silva, Fernanda (GlaxoSmithKline (GSK)) ;
Ahonen, Anitta (University of Tampere) ;
Avelino-Silva, Thiago (University of São Paulo Medical School) ;
Barba-Gomez, José Fernando (Instituto Dermatológico de Jalisco) ;
Berglund, Johan (Blekinge Institute of Technology) ;
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Caso, Covadonga (Hospital Clínico San Carlos (Madrid)) ;
Chlibek, Roman (University of Defence) ;
Choi, Won Suk (Korea University College of Medicine) ;
Cunningham, Anthony (University of Sydney) ;
Desole, Maria Giuseppina (Servizio di Igiene Pubblica) ;
Eizenberg, Peter (Doctors of Ivanhoe) ;
Esen, Meral (University Clinic of Tübingen) ;
Espié, Emmanuelle (GlaxoSmithKline (GSK)) ;
Gervais, Pierre (Q&T Research Sherbrooke) ;
Ghesquiere, Wayne (University of British Columbia) ;
Godeaux, Olivier O. (GlaxoSmithKline (GSK)) ;
Gorfinkel, Iris (York University) ;
Hui, David Shu Cheong (Prince of Wales Hospital (Australia)) ;
Hwang, Shinnjang (Taipei Veterans General Hospital and National Yang Ming University School of Medicine) ;
Korhonen, Tiina (University of Tampere Medical School) ;
Kovac, Martina (GlaxoSmithKline (GSK)) ;
Ledent, Edouard Y. (GlaxoSmithKline (GSK)) ;
Leung, Edward Man Fuk (Hong Kong Association of Gerontology) ;
Levin, Myron (University of Colorado Anschutz Medical Campus) ;
Perez, Silvia Narejos (CAP Centelles) ;
de Andrade Neto, José Luiz (Instituto A. Z. de Pesquisa e Ensino) ;
Pauksens, Karlis (Uppsala University Hospital) ;
Poder, Airi (Kliiniliste Uuringute Keskus) ;
Rodriguez de la Pinta, Maria Luisa (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Rombo, Lars (Uppsala University) ;
Schwarz, Tino Francis (Standort Juliusspital) ;
Smetana, Jan (University of Defence) ;
Staniscia, Tommaso (University G. d'Annunzio of Chieti-Pescara) ;
Tinoco-Fávila, Juan Carlos (Hospital General de Durango) ;
Toma, Azhar (Manna Research) ;
Vastiau, Ilse (GlaxoSmithKline (GSK)) ;
Vesikari, Timo H. (University of Tampere) ;
Volpi, Antonio (A.O. Univesitaria Policlinico Tor Vergata) ;
Watanabe, Daisuke (Kobe University Graduate School of Medicine) ;
Weckx, Lily (Federal University of Sao Paulo) ;
Zahaf, Toufik (GlaxoSmithKline (GSK)) ;
Universitat Autònoma de Barcelona
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies. [...]
2019 - 10.1016/j.vaccine.2019.03.043
Vaccine, Vol. 37 Núm. 18 (24 2019) , p. 2482-2493
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585.
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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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586.
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12 p, 1.1 MB |
Inflammatory biomarkers in Alzheimer's disease plasma
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Morgan, Angharad R. (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, Cardiff University (Regne Unit)) ;
Touchard, Samuel (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University (Regne Unit)) ;
Leckey, Claire A. (Cardiff University (Regne Unit)) ;
O'Hagan, Caroline (Cardiff University (Regne Unit)) ;
Nevado-Holgado, Alejo (University of Oxford (Regne Unit)) ;
Barkhof, Frederik (University College London) ;
Bertram, Lars (Max Planck Institute for Molecular Genetics (Alemanya)) ;
Blin, Olivier (Aix-Marseille University (França)) ;
Bos, Isabelle (Maastricht University (Països Baixos)) ;
Dobricic, Valerija (University of Lübeck (Alemanya)) ;
Engelborghs, Sebastiaan (Institute Born-Bunge (Bèlgica)) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli (Brescia, Itàlia)) ;
Froelich, Lutz (University of Heidelberg (Alemanya)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology (Leuven, Bèlgica)) ;
Johannsen, Peter (Karolinska Institutet (Stockholm, Sweden)) ;
Kettunen, Petronella (University of Gothenburg (Gothenburg, Suècia)) ;
Kłoszewska, Iwona (Medical University of Lodz (Lodz, Poland)) ;
Legido-Quigley, Cristina (Imperial College London) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Lage, Pablo (Fundación CITA-Alzheimer Fundazioa (San Sebastian, Spain)) ;
Mecocci, Patrizia (University of Perugia (Itàlia)) ;
Meersmans, Karen (Laboratory for Cognitive Neurology (Bèlgica)) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Peyratout, Gwendoline (Lausanne University Hospital (Suïssa)) ;
Popp, Julius (Hopitaux Universitaires Geneve and Universite de Geneve (Suïssa)) ;
Richardson, Jill (GlaxoSmithKline R&D (Regne Unit)) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Scheltens, Philip (Vrije Universiteit (Països Baixos)) ;
Streffer, Johannes (University of Antwerp) ;
Soininen, Hikka (University of Eastern Finland) ;
Tainta, Mikel (Fundación CITA Alzheimer (Sant Sebastià, País Basc)) ;
Teunissen, Charlotte E (University Hospitals Leuven (Bèlgica)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Vandenberghe, Rik (Amsterdam University Medical Centers (Països Baixos)) ;
Visser, Pieter Jelle (Maastricht University (Països Baixos)) ;
Vos, Stephanie (Maastricht University (Països Baixos)) ;
Wahlund, Lars Olof (Karolinska Institutet (Estocolm, Suècia)) ;
Wallin, Anders (University of Gothenburg Sahlgrenska Academy) ;
Westwood, Sarah (University of Oxford (Regne Unit)) ;
Zetterberg, Henrik (UK Dementia Research Institute (Londres, Regne Unit)) ;
Lovestone, Simon (University of Oxford (Regne Unit)) ;
Morgan, B. Paul (Cardiff University (Regne Unit)) ;
Bullmore, Edward (University of Cambridge (Regne Unit)) ;
Bhatti, Junaid (University of Cambridge (Regne Unit)) ;
Chamberlain, Samuel J. (University of Cambridge (Regne Unit)) ;
Correia, Marta Morgado (University of Cambridge (Regne Unit)) ;
Crofts, Anna L. (Université de Sherbrooke (Canadà)) ;
Dickinson, Amber (Addenbroke's Hospital (Cambridge, Regne Unit)) ;
Foster, Andy C. (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit)) ;
Kitzbichler, Manfred G. (University of Cambridge (Regne Unit)) ;
Knight, Clare (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit)) ;
Lynall, Mary-Ellen (University of Cambridge (Regne Unit)) ;
Maurice, Christina (University of Cambridge (Regne Unit)) ;
O'Donnell, Ciara M. (University College London (Regne Unit)) ;
Pointon, Linda J. (University of Cambridge (Regne Unit)) ;
St George Hyslop, Peter (University of Cambridge (Regne Unit)) ;
Turner, Lorinda (University of Cambridge (Regne Unit)) ;
Vertes, Petra E. (University of Cambridge (Regne Unit)) ;
Widmer, Barry (University of Cambridge (Regne Unit)) ;
Williams, Guy (University of Cambridge (Regne Unit)) ;
Cavanagh, Jonathan T. O. (Karolinska Institutet (Estocolm, Suècia)) ;
Deith, Catherine (Southern General Hospital Glasgow (Escòcia)) ;
Farmer, Scott (Bio Med Sciences Inc.(Galveston, Estats Units)) ;
McClean, John (NHS Greater Glasgow and Clyde (Glasgow, Escòcia)) ;
McColl, Alison (College of Medical, Veterinary & Life Sciences (Glasgow, Escòcia)) ;
McPherson, Andrew (Addenbrooke's Hospital (Cambridge, Regne Unit)) ;
Scouller, Paul (Addenbrooke's Hospital (Cambridge, Regne Unit)) ;
Sutherland, Murray (NHS Greater Glasgow and Clyde (Glasgow, Escòcia)) ;
Boddeke, Erik W.G.M. (Københavns UniversitetThe institution (Copenhaguen, Dinamarca)) ;
Khan, Shahid (GlaxoSmithKline plc. (Regne Unit)) ;
Murphy, Philip Stephen (GlaxoSmithKline plc. (Regne Unit)) ;
Parker, Christine A. (Wellcome Trust (Londres, Regne Unit)) ;
Patel, Jai (GlaxoSmithKline plc. (Regne Unit)) ;
Jones, Declan (Janssen Pharmaceuticals (Titusville, Estats Units)) ;
de Boer, Peter (Janssen Research & Development (Beerse, Bèlgica)) ;
Kemp, John A. (KU Leuven- University Hospital Leuven (Bèlgica)) ;
Drevets, Wayne Curtis (Janssen Research & Development (Beerse, Bèlgica)) ;
Nye, Jeffrey S. (Janssen Research & Development (Beerse, Bèlgica)) ;
Wittenberg, Gayle M. (Janssen Research & Development (Beerse, Bèlgica)) ;
Isaac, John T.R. (Johnson & Johnson (Estats Units)) ;
Bhattacharya, Anindya (Janssen Research & Development (Beerse, Bèlgica)) ;
Carruthers, Niicholas L. (Janssen Research & Development (Beerse, Bèlgica)) ;
Kolb, Hartmuth Christian (Janssen Research & Development (Beerse, Bèlgica)) ;
Pariante, Carmine M. (King's College London (Regne Unit)) ;
Turkheimer, Federico (King's College London (Regne Unit)) ;
Barker, Gareth John (King's College London (Regne Unit)) ;
Byrom, Heidi (King's College London (Regne Unit)) ;
Cash, Diana (King's College London (Regne Unit)) ;
Cattaneo, Annamaria (King's College London (Regne Unit)) ;
Gee, Anthony (King's College London (Regne Unit)) ;
Hastings, Caitlín N.M. (King's College London (Regne Unit)) ;
Mariani, Nicole (King's College London (Regne Unit)) ;
McLaughlin, Anna Patricia (King's College London (Regne Unit)) ;
Mondelli, Valeria (King's College London (Regne Unit)) ;
Nettis, Maria Antonietta (King's College London (Regne Unit)) ;
Nikkheslat, Naghmeh (King's College London (Regne Unit)) ;
Randall, Karen (King's College London (Regne Unit)) ;
Sheridan, Hannah C. (King's College London (Regne Unit)) ;
Simmons, Camilla (King's College London (Regne Unit)) ;
Singh, Nisha (King's College London (Regne Unit)) ;
Van Loo, Victoria (King's College London (Regne Unit)) ;
Vicente-Rodríguez, Marta (King's College London (Regne Unit)) ;
Wood, Tobias (King's College London (Regne Unit)) ;
Worrell, Courtney (King's College London (Regne Unit)) ;
Zajkowska, Zuzanna (King's College London (Regne Unit)) ;
Plath, Niels (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Egebjerg, Jan (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Eriksson, Hans (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Gastambide, Francois (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Adams, Karen Husted (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Jeggo, Ross D. (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Thomsen, Christian (Aalborg Universitetshospital (Aalborg, Dinamarca)) ;
Pederson, Jan Torleif (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Campbell, Brian M. (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ;
Möller, Thomas (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ;
Nelson, Bob (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Zorn, Stevin H. (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ;
O'Connor, Jason (University of Texas Hlth Sci Ctr San Antonio(Estats Units)) ;
Attenburrow, Mary Jane (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Baird, Alison (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Benjamin, Jithen (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Clare, Stuart (John Radcliffe Hosp, Oxford Ctr Funct MRI Brain (Oxford, Anglaterra)) ;
Cowen, Philip (University of Oxford (Anglaterra)) ;
Huang, I-Shuo Wade (Kennedy Inst Rheumatol (Oxford, Anglaterra)) ;
Hurley, Samuel A. (University of Wisconsin-Madison (Madison, Estats Units)) ;
Jones, Helen (Warneford Hosp, NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Mada, Francisca (Neurosciences & Neurology) ;
Nevado-Holgado, Alejo (University of Oxford (Anglaterra)) ;
Oladejo, Akitayo (Metropolitan Hospital Center (New York, Estats Units)) ;
Ribe, Elena (King's College London (Londres, Anglaterra)) ;
Smith, Katy (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Vyas, Anviti (University of Oxford (Oxford, Anglaterra)) ;
Hughes, Zoe (Praxis Precision Medicines (Cambridge, Regne Unit)) ;
Balice-Gordon, Rita (Sanofi S.A. (Gentilly, França)) ;
Duerr, James M. (Pfizer Inc.(New York, Estats Units)) ;
Piro, Justin R. (Pfizer Inc.(New York, Estats Units)) ;
Sporn, Jonathan (Gilgamesh Pharmaceut (New York, Estats Units)) ;
Perry, V. Hugh (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Cleal, Madeleine (University of Portsmouth (Anglaterra)) ;
Fryatt, Gemma (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Gomez-Nicola, Diego (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Mancuso, Renzo (University of Southampton (Anglaterra)) ;
Reynolds, Richard (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Harrison, Neil (University fo Sussex (Brighton, Anglaterra)) ;
Cercignani, Mara (University fo Sussex (Brighton, Anglaterra)) ;
Clarke, Charlotte L. (University of Sussex (Brighton, Regne Unit)) ;
Hoskins, Elizabeth (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit)) ;
Kohn, Charmaine (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit)) ;
Murray, Rosemary (Addenbrooke's Hospital (Cambridge, Regne Unit)) ;
Wilcock, Lauren (Sussex Partnership NHS Fdn Trust (Hove, Anglaterra)) ;
Wlazly, Dominika (Brighton and Sussex University Hospitals NHS Trust (Sussex, Anglaterra)) ;
Mount, Howard T.J. (University of Toronto (Toronto, Canadà)) ;
Universitat Autònoma de Barcelona
Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. [...]
2019 - 10.1016/j.jalz.2019.03.007
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 776-787
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587.
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12 p, 2.2 MB |
Progress against inequalities in mortality : register-based study of 15 European countries between 1990 and 2015
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Mackenbach, J.P (Erasmus MC) ;
Rubio Valverde, José (Erasmus MC) ;
Bopp, Matthias (University of Zürich) ;
Brønnum-Hansen, Henrik (Copenhagen University) ;
Costa, Giuseppe (University of Turin) ;
Deboosere, Patrick (Vrije Universiteit Brussel) ;
Kalediene, Ramune (Lithuanian University of Health Sciences) ;
Kovács, Katalin (Demographic Research Institute) ;
Leinsalu, Mall (National Institute for Health Development) ;
Martikainen, Pekka (University of Helsinki) ;
Menvielle, Gwenn (Sorbonne Universités) ;
Rodríguez-Sanz, Maica (Institut d'Investigació Biomèdica Sant Pau) ;
Nusselder, Wilma J. (Erasmus MC) ;
Universitat Autònoma de Barcelona
Socioeconomic inequalities in mortality are a challenge for public health around the world, but appear to be resistant to policy-making. We aimed to identify European countries which have been more successful than others in narrowing inequalities in mortality, and the factors associated with narrowing inequalities. [...]
2019 - 10.1007/s10654-019-00580-9
European Journal of Epidemiology, Vol. 34 Núm. 12 (january 2019) , p. 1131-1142
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588.
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10 p, 324.1 KB |
Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome : ODYSSEY OUTCOMES Trial
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Jukema, J.Wouter (Leiden University Medical Center) ;
Szarek, Michael (State University of New York) ;
Zijlstra, Laurien E. (Leiden University Medical Center) ;
de Silva, H.Asita (University of Kelaniya) ;
Bhatt, Deepak L (Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School) ;
Bittner, Vera A. (University of Alabama at Birmingham) ;
Diaz, Rafael (Cardiovascular Institute of Rosario) ;
Edelberg, Jay M. (Sanofi) ;
Goodman, Shaun G. (St. Michael's Hospital. University of Toronto) ;
Hanotin, Corinne (Sanofi) ;
Harrington, Robert A. (Stanford University) ;
Karpov, Yuri (Russian Cardiological Scientific-Productive Complex) ;
Moryusef, Angèle (Sanofi) ;
Pordy, Robert (Regeneron Pharmaceuticals. Inc.) ;
Prieto, Juan C. (University of Chile Clinical Hospital) ;
Roe, Matthew T. (Duke University School of Medicine) ;
White, Harvey D. (Green Lane Cardiovascular Services Auckland City Hospital) ;
Zeiher, Andreas Michael (Goethe University) ;
Schwartz, Gregory G. (University of Colorado School of Medicine) ;
Steg, P.Gabriel (Royal Brompton Hospital (Londres)) ;
Cequier, Ángel (Hospital Universitari de Bellvitge) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron) ;
Mata Pericas, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Bruguera Cortada, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Gusi Tragant, Gabriel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Coca Payeras, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin-kexin type 9 inhibition in such patients is undetermined. [...]
2019 - 10.1016/j.jacc.2019.03.013
Journal of the American College of Cardiology, Vol. 74 Núm. 9 (march 2019) , p. 1167-1176
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589.
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590.
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12 p, 901.7 KB |
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
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Herraiz-Martínez, Adela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Llach, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Tarifa, Carmen (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gandía, Jorge (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Jiménez-Sábado, Verónica (Institut d'Investigació Biomèdica Sant Pau) ;
Lozano-Velasco, E. (Universidad de Jaén) ;
Serra, Selma A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vallmitjana, A. (Universitat Politècnica de Catalunya) ;
Vázquez Ruiz De Castroviejo, E. (Regional Hospital Ciudad de Jaén) ;
Benítez, R. (Universitat Politècnica de Catalunya) ;
Aránega, Amelia E (Universidad de Jaén) ;
Muñoz-Guijosa, C. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Franco, D. (Universidad de Jaén) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Hove-Madsen, Leif (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers their clinical utility. [...]
2019 - 10.1093/cvr/cvy215
Cardiovascular research, Vol. 115 Núm. 3 (january 2019) , p. 578-589
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