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12 p, 7.7 MB |
Differential protein expression in endothelial cells exposed to serum from patients with acute graft-vs-host disease, depending on steroid response
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Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Rovira, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Penack, Olaf (Universität zu Berlin, Germany) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Graft-versus-host disease (GVHD) is a complication of allogeneic haematopoietic cell transplantation. Endothelial injury is crucial as pathophysiological substrate for GVHD. GVHD first-line treatment is high-dose corticosteroids, although some patients are steroid-refractory. [...]
2023 -  10.1111/jcmm.17712
Journal of Cellular and Molecular Medicine, Vol. 27 Núm. 9 (may 2023) , p. 1227-1238
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12.
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15 p, 1.5 MB |
ApoL1 levels in high density lipoprotein and cardiovascular event presentation in patients with familial hypercholesterolemia
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Cubedo, Judit (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso, Rodrigo (Jimenez Diaz Foundation) ;
Mata, Pedro (Fundación Hipercolesterolemia Familiar) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
HDL composition rather than HDL-cholesterol (HDL-C) levels seems to be a key determinant of HDL-induced atheroprotection. Heterozygous familial hypercholesterolemia (FH) patients, with lifelong exposure to high LDL levels, show a high prevalence of premature coronary artery disease. [...]
2016 - 10.1194/jlr.P061598
Journal of Lipid Research, Vol. 57 Núm. 6 (june 2016) , p. 1059-1073
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8 p, 508.4 KB |
Biomarkers expression in benign breast diseases and risk of subsequent breast cancer : a case-control study
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Posso, Margarita (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Corominas, Josep (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Serrano, Laia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Román, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torá-Rocamora, Isabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domingo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Romero, Anabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Quintana, M.J. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Vernet-Tomas, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Baré i Mañas, Marisa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vidal, Carmen (Institut Català d'Oncología) ;
Sánchez, Mar (Catalunya. Generalitat) ;
Saladié, Francina (Fundación Liga para la Investigación y Prevención del Cáncer (Tarragona, Catalunya)) ;
Natal, Carmen (Programa de Detección de Cáncer de Mama del Principado de Asturias) ;
Ferrer, Joan (Hospital de Santa Caterina (Salt, Girona)) ;
Servitja, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sala, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Castells, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Burón, A. ;
Rodríguez-Arana, A. ;
Romero, A. ;
Vernet, M. ;
Andreu, Xavier ;
Milà, N. ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández-Somoano, A. ;
Galceran, J. ;
Espinàs, J.A. ;
Universitat Autònoma de Barcelona
Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. [...]
2017 - 10.1002/cam4.1080
Cancer Medicine, Vol. 6 Núm. 6 (june 2017) , p. 1482-1489
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11 p, 1.2 MB |
Clinical outcome and biomarker assessments of a multi-centre phase II trial assessing niraparib with or without dostarlimab in recurrent endometrial carcinoma
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Madariaga, Ainhoa (Universitat Autònoma de Barcelona) ;
Garg, Swati (University Health Network, Toronto, Canada) ;
Tchrakian, Nairi (University Health Network, Toronto, Canada) ;
Dhani, Neesha C. (University of Toronto, Canada) ;
Jimenez, Waldo (Juravinski Cancer Centre, Hamilton, Canada) ;
Welch, Stephen (London Health Sciences Center, London, Canada) ;
MacKay, Helen (Odette Cancer Centre. Sunnybrook Health Sciences Centre, Toronto, Canada) ;
Ethier, Josee-Lyne (Kingston Health Sciences Cancer Centre, Kingston, Canada) ;
Gilbert, Lucy (Royal Victoria Hospital, Montréal, Canada) ;
Li, Xuan (University Health Network, Toronto, Canada) ;
Rodriguez, Angela (University Health Network, Toronto, Canada) ;
Chan, Lucy (University Health Network, Toronto, Canada) ;
Bowering, Valerie (University Health Network, Toronto, Canada) ;
Clarke, Blaise (University Health Network, Toronto, Canada) ;
Zhang, Tong (University of Toronto, Canada) ;
King, Ian (University of Toronto, Canada) ;
Downs, Gregory (University of Toronto, Canada) ;
Stockley, Tracy (University of Toronto, Canada) ;
Wang, Lisa (University of Toronto, Toronto, Canada) ;
Udagani, Smitha (University Health Network, Toronto, Canada) ;
Oza, Amit M. (University of Toronto, Canada) ;
Lheureux, Stephanie (University of Toronto, Canada)
This multi-centre, non-randomized, open-label, phase II trial (NCT03016338), assessed niraparib monotherapy (cohort 1, C1), or niraparib and dostarlimab (cohort 2, C2) in patients with recurrent serous or endometrioid endometrial carcinoma. [...]
2023 - 10.1038/s41467-023-37084-w
Nature communications, Vol. 14 (2023) , art. 1452
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8 p, 798.4 KB |
Circulating markers of bone turnover
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Vervloet, Marc G. (Amsterdam UMC. University Medical Center) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Brandenburg, Vincent M. (RWTH University Hospital Aachen (Alemanya)) ;
Covic, Adrian ;
Cozzolino, Mario ;
Evenepoel, Pieter ;
Goldsmith, David ;
Massy, Ziad ;
Mazzaferro, Sandro ;
Ureña-Torres, Pablo ;
Universitat Autònoma de Barcelona
Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. [...]
2017 - 10.1007/s40620-017-0408-8
Journal of Nephrology, Vol. 30 Núm. 5 (january 2017) , p. 663-670
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15 p, 1.2 MB |
Programmed death-ligand (PD-L1), epidermal growth factor (EGF), relaxin and metalloproteinase-3 (MMP3), potential biomarkers of malignancy in canine mammary neoplasia
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Galadima, Makchit ;
Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Rivera del Álamo, Maria Montserrat (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Gene expression has been suggested as a putative tool for prognosis and diagnosis in canine mammary neoplasia (CMNs). In the present study, 58 formalin-fixed paraffin-embedded (FFPE) paraffined canine mammary neoplasias from 27 different bitches were included. [...]
2024 - 10.3390/ijms25021170
International journal of molecular sciences, Vol. 25 (2024) , p. 1170
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135 p, 1.9 MB |
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias : An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
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Lewczuk, Piotr (University Hospital of Białystok) ;
Riederer, Peter (University Hospital Würzburg) ;
O'Bryant, Sid E. (University of North Texas Health Science Center) ;
Verbeek, Marcel M. (Radboud Alzheimer center) ;
Dubois, Bruno (Salpêtrièrie Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Jellinger, Kurt A. (Institute of Clinical Neurobiology) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Ramirez, Alfredo (University of Cologne) ;
Parnetti, Lucilla (University of Perugia) ;
Jack Jr, Clifford R. (Mayo Clinic) ;
Teunissen, Charlotte E. (VU University Medical Center Amsterdam) ;
Hampel, Harald (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Jessen, Frank (German Center for Neurodegenerative Disorders (DZNE)) ;
Glodzik, Lidia (NYU Langone Medical Center) ;
de Leon, Mony J. (NYU Langone Medical Center) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Jansen, Willemijn J. (Maastricht University) ;
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Andreasson, Ulf (The Sahlgrenska Academy at the University of Gothenburg) ;
Otto, Markus (University of Ulm) ;
Mollenhauer, Brit (Kassel and University Medical Center Göttingen) ;
Wiltfang, Jens (University of Aveiro) ;
Turner, Martin R. (University of Oxford) ;
Zerr, Inga (German Center for Neurodegenerative Diseases) ;
Handels, Ron (Karolinska Institutet (Estocolm, Suècia)) ;
Thompson, Alexander G. (University of Oxford) ;
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia)) ;
Ermann, Natalia (Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Trojanowski, John Q. (University of Pennsylvania) ;
Karaca, Ilker (University of Bonn) ;
Wagner, Holger (University of Bonn) ;
Oeckl, Patrick (University of Ulm) ;
van Waalwijk van Doorn, Linda (Radboud Alzheimer center) ;
Bjerke, Maria (University of Antwerp) ;
Kapogiannis, Dimitrios (National Institute on Aging/National Institutes of Health (NIA/NIH)) ;
Kuiperij, H.Bea (Radboud Alzheimer center) ;
Farotti, Lucia (University of Perugia) ;
Li, Yi (NYU Langone Medical Center) ;
Gordon, Brian A. (Washington University School of Medicine) ;
Epelbaum, Stéphane (Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A)) ;
Vos, Stephanie J.B. (Maastricht University) ;
Klijn, Catharina J.M. (Radboud Alzheimer Center) ;
Van Nostrand, William E. (Stony Brook University) ;
Minguillon, Carolina (Fundació Pasqual Maragall) ;
Schmitz, Matthias (University Medical School) ;
Gallo, Carla (Universidad Peruana Cayetano Heredia) ;
Lopez Mato, Andrea (Maimonides University) ;
Thibaut, Florence (University Hospital Cochin-Site Tarnier 89 rue d'Assas) ;
Lista, Simone (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Kornhuber, Johannes (Universitätsklinikum Erlangen) ;
Universitat Autònoma de Barcelona
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. [...]
2018 - 10.1080/15622975.2017.1375556
World Journal of Biological Psychiatry, Vol. 19 Núm. 4 (19 2018) , p. 244-328
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9 p, 745.8 KB |
The EMIF-AD Multimodal Biomarker Discovery study : Design, methods and cohort characteristics
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Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (Katholieke Universiteit Leuven) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Engelborghs, Sebastiaan (University of Antwerp) ;
Frisoni, Giovanni (IRCCS Instituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Fundació Pasqual Maragall) ;
Wallin, Anders (Institute of Neuroscience and Physiology) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Baird, Alison (University of Oxford) ;
Dobson, Richard (NIHR University College London Hospitals) ;
Legido-Quigley, Cristina (King's College London) ;
Sleegers, Kristel (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Bertram, Lars (University of Oslo) ;
Ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Barkhof, Frederik (Amsterdam UMC. University Medical Center) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Lovestone, Simon (University of Oxford) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Universitat Autònoma de Barcelona
There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's disease (AD) in the predementia stages and to predict the rate of decline. Therefore, we set up the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study. [...]
2018 - 10.1186/s13195-018-0396-5
Alzheimer's research & therapy, Vol. 10 Núm. 1 (june 2018) , p. 64
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20.
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6 p, 731.5 KB |
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
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Stamate, Daniel (University of London) ;
Kim, Min (Steno Diabetes Center Copenhagen) ;
Proitsi, Petroula (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (King's College London) ;
Bos, Isabelle (Amsterdam UMC) ;
Vos, Stephanie J.B. (Maastricht University) ;
Vandenberghe, Rik (Amsterdam UMC) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Bordet, Régis (University of Lille) ;
Ramit, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundacion CITA-alzheimer Fundazioa) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at the University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (University of Antwerp) ;
Visser, Pieter J. (Amsterdam UMC) ;
Lovestone, Simon (Janssen-Cilag UK Ltd) ;
Legido-Quigley, Cristina (King's College London) ;
Universitat Autònoma de Barcelona
Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. [...]
2019 - 10.1016/j.trci.2019.11.001
Alzheimer's & dementia, Vol. 5 (2019) , p. 933-938
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