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11.
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6 p, 870.5 KB |
Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy : differences according to KRAS G12C vs. non-G12C
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Notario, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cerdà, Gabriela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanz, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz-Mármol, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domènech, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Costa, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mate, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saigí, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. In this retrospective study, we examined 103 patients with KRAS-mutant lung adenocarcinoma who were treated with immunotherapy-based regimens and we evaluated the clinical outcomes according to PD-L1 expression and the type of KRAS mutation. [...]
2023 -  10.3389/fonc.2023.1239000
Frontiers in Oncology, Vol. 13 (october 2023)
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12.
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8 p, 715.4 KB |
Head and neck cancers survival in Europe, Taiwan, and Japan : results from RARECAREnet Asia based on a privacy-preserving federated infrastructure
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Botta, Laura (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Matsuda, Tomohiro (Insititute of Cancer Control. National Cancer Center (Japò)) ;
Charvat, Hadrien (National Cancer Center (Japò)) ;
Chiang, Chung-Ju (Taiwan Cancer Registry Center) ;
Lee, Wen-Chung (Taiwan Cancer Registry Center) ;
van Gestel, Anna Jacoba (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Martin, Frank (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Geleijnse, Gijs (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Cellamare, Mattheo (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Bonfarnuzzo, Simone (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra) ;
Mousavi, Mohsen (East Switzerland Cancer Registry) ;
Craig, Stefano (Queen's University Belfast) ;
Rodrigues, Jessica (Porto Comprehensive Cancer Centre (Portugal)) ;
Rubió-Casadevall, Jordi (Institut de Recerca Biomèdica de Lleida) ;
Licitra, Lisa (Department of Oncology and Hemato-Oncology. University of Milan) ;
Cavalieri, Stephanie (Department of Oncology and Hemato-Oncology. University of Milan) ;
Resteghini, Carlo (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Trama, Annalisa (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries. [...]
2023 - 10.3389/fonc.2023.1219111
Frontiers in Oncology, Vol. 13 (2023) , p. 1219111
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13.
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16 p, 2.6 MB |
uPA/uPAR and SERPINE1 in head and neck cancer : Role in tumor resistance, metastasis, prognosis and therapy
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Pavón, Miguel Angel (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Arroyo-Solera, Irene (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Céspedes, María Virtudes (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Casanova Rigat, Isolda (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
León i Vintró, Xavier (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mangues, Ramon 1957- (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Universitat Autònoma de Barcelona
There is strong evidence supporting the role of the plasminogen activator system in head and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase plasminogen activator)/uPAR (urokinase plasminogen activator receptor) and SERPINE1 components. [...]
2016 - 10.18632/oncotarget.10344
Oncotarget, Vol. 7 Núm. 35 (2016) , p. 57351-57366
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14.
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9 p, 1.4 MB |
Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features
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Font, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domenech, Montserrat (Althaia Xarxa Assistencial Universitària de Manresa) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marqués, Miriam (Centro Nacional de Investigaciones Oncológicas) ;
Benítez, Raquel (Centro Nacional de Investigaciones Oncológicas) ;
Ruiz de Porras, Vicenç (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gago, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sant, Francesc (Althaia Xarxa Assistencial Universitària de Manresa) ;
Lopez, Hector (Althaia Xarxa Assistencial Universitària de Manresa) ;
Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Malats, Núria (Centro Nacional de Investigaciones Oncológicas) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Real, Francisco X. (Universitat Pompeu Fabra)
Background and objective: Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological variables can identify patients likely to respond, highlighting the need for predictive biomarkers. [...]
2023 - 10.3389/fonc.2023.1155244
Frontiers in Oncology, Vol. 13 (august 2023)
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15.
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53 p, 9.1 MB |
Recent advances on smart glycoconjugate vaccines in infections and cancer
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Anderluh, Marko (Univerza V Ljubljani) ;
Berti, Francesco (Technical R&D, GSK Vaccines S.r.l., Siena, Italy) ;
Bzducha-Wróbel, Anna (Warsaw University of Life Sciences-SGGW, Warszawa, Poland) ;
Chiodo, Fabrizio (Vrije Universiteit Amsterdam, The Netherlands) ;
Colombo, Cinzia (University of Milan, Italy) ;
Compostella, Federica (University of Milan, Italy) ;
Durlik, Katarzyna (Jan Kochanowski University, Kielce, Poland) ;
Ferhati, Xhenti (University of Florence, Sesto Fiorentino, Italy) ;
Holmdahl, Rikard (Karolinska Institute, Stockholm, Sweden) ;
Jovanovic, Dragana (University of Belgrade, Serbia) ;
Kaca, Wieslaw (Jan Kochanowski University, Kielce, Poland) ;
Lay, Luigi (University of Milan, Italy) ;
Marinovic-Cincovic, Milena (University of Belgrade, Serbia) ;
Marradi, Marco (University of Florence, Italy) ;
Ozil, Musa (Recep Tayyip Erdogan University, Rize, Turkey) ;
Polito, Laura (National Research Council, CNR-SCITEC, Milan, Italy) ;
Reina, Jose Juan (Universidad de Malaga-IBIMA) ;
Reis, Celso A. (University of Porto, Portugal) ;
Sackstein, Robert (Florida International University, Miami, USA) ;
Silipo, Alba (Complesso Universitario Monte Sant'Angelo, Napoli, Italy) ;
Švajger, Urban (Blood Transfusion Center of Slovenia, Ljubljana, Slovenia) ;
Vaněk, Ondřej (Charles University, Prague, Czech Republic) ;
Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Richichi, Barbara (University of Florence, Italy) ;
van Vliet, Sandra J. (Vrije Universiteit Amsterdam, The Netherlands)
Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. [...]
2022 - 10.1111/febs.15909
FEBS Journal, Vol. 289 Núm. 14 (july 2022) , p. 4251-4303
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16.
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16 p, 3.4 MB |
CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
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Dragon, Anna Christina (Hannover Medical School) ;
Beermann, Luca Marie (Hannover Medical School) ;
Umland, Melina (Hannover Medical School) ;
Bonifacius, Agnes (Hannover Medical School) ;
Malinconico, Chiara (Hannover Medical School) ;
Ruhl, Louisa (Hannover Medical School) ;
Kehler, Patrik (Glycotope GmbH) ;
Gellert, Johanna (Glycotope GmbH) ;
Weiß, Lisa (Glycotope GmbH) ;
Mayer-Hain, Sarah (Glycotope GmbH) ;
Zimmermann, Katharina (Hannover Medical School) ;
Riese, Sebastian (Hannover Medical School) ;
Thol, F. (Department of Hematology. Hannover Medical School) ;
Beutel, Gernot (Hannover Medical School) ;
Maecker-Kolhoff, B. (Department of Pediatric Hematology and Oncology. Hannover Medical School) ;
Yamamoto, Felicitas (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blasczyk, Rainer (Hannover Medical School) ;
Schambach, Axel (Hannover Medical School) ;
Hust, Michael (Department of Medical Biotechnology. Technical University of Braunschweig) ;
Hudecek, Michael (Department of Internal Medicine II. University Hospital of Würzburg) ;
Eiz-Vesper, Britta (Hannover Medical School) ;
Universitat Autònoma de Barcelona
Introduction: Chimeric antigen receptor-engineered T cells (CAR-Ts) are investigated in various clinical trials for the treatment of cancer entities beyond hematologic malignancies. A major hurdle is the identification of a target antigen with high expression on the tumor but no expression on healthy cells, since "on-target/off-tumor" cytotoxicity is usually intolerable. [...]
2023 - 10.3389/fimmu.2023.1219165
Frontiers in immunology, Vol. 14 (2023) , p. 1219165
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17.
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17 p, 4.7 MB |
Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas
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Gallardo-Gómez, María (Universidade de Vigo) ;
Rodríguez-Girondo, Mar (Department of Medical Statistics and Bioinformatics. Leiden University Medical Centre) ;
Planell, Núria (Universidad Pública de Navarra) ;
Moran, Sebastián (Institut d'Investigació Biomèdica de Bellvitge) ;
Bujanda, Luis (Universidad del País Vasco. Instituto de Investigación Sanitaria Biodonostia) ;
Etxart, Ane (Department of Surgery. Hospital Universitario Donostia) ;
Castells, Antoni (Universitat de Barcelona) ;
Balaguer, Francesc (Universitat de Barcelona) ;
Jover, Rodrigo (Servicio de Medicina Digestiva. Universidad Miguel Hernández) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cubiella, Joaquin (Department of Gastroenterology. Complexo Hospitalario Universitario de Ourense. Instituto de Investigación Biomédica Galicia Sur. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gómez-Cabrero, David (Mucosal & Salivary Biology Division. King's College London Dental Institute) ;
De Chiara, Loretta (Galicia Sur Health Research Institute) ;
Universitat Autònoma de Barcelona
Background: Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. [...]
2023 - 10.1186/s13148-023-01570-1
Clinical Epigenetics, Vol. 15 Núm. 1 (december 2023) , p. 157
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32 p, 5.0 MB |
Childhood and Adolescent Central Nervous System Tumours in Spain : Incidence and Survival over 20 Years: A Historical Baseline for Current Assessment
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Chirlaque, María D. (Universidad de Murcia. Departamento de Epidemiología) ;
Peris-Bonet, Rafael (Spanish Registry of Childhood Tumours. University of Valencia) ;
Sánchez, Antonia (Department of Epidemiology. Murcia Regional Health Authority) ;
Cruz, Ofelia (Hospital Sant Joan de Déu (Manresa)) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-Ávila, Gonzalo (Castile-La Mancha Cancer Registry) ;
Quirós-García, José R. (Asturias Cancer Registry. Public Health Directorate) ;
Almela-Vich, Fernando (Valencian Regional Childhood Cancer Registry) ;
López de Munain, Arantza (Basque Country Cancer Registry) ;
Sánchez, María J. (Granada Bio-Health Research Institute) ;
Franch-Sureda, Paula (Mallorca Cancer Registry. Balearic Isles Health Research Institute) ;
Ardanaz, Eva (Navarre Health Research Institute) ;
Galceran, Jaume (Universitat Rovira i Virgili) ;
Martos, Carmen (Foundation for the Promotion of Health and Biomedical Research in the Valencian Region) ;
Salmerón, Diego (Universidad de Murcia. Department of Health and Social Sciences) ;
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Botta, Laura (Istituto Nazionale dei Tumori) ;
Cañete, Adela (Universitat de València)
Background: Central nervous system (CNS) neoplasms are highly frequent solid tumours in children and adolescents. While some studies have shown a rise in their incidence in Europe, others have not. Survival remains limited. [...]
2023 - 10.3390/cancers15245889
Cancers, Vol. 15 Núm. 24 (december 2023) , p. 5889
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Pan-cancer proteogenomics connects oncogenic drivers to functional states
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Li, Yize (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tokheim, Collin (Harvard T.H. Chan School of Public Health) ;
Bailey, Matthew H. (Brigham Young University) ;
Yaron, Tomer (Weill Cornell Medicine) ;
Stathias, Vasileios (University of Miami Miller School of Medicine) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Imbach, Kathleen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cao, Song (McDonnell Genome Institute) ;
Anand, Shankara (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Akiyama, Yo (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Liu, Wenke (NYU Grossman School of Medicine) ;
Wyczalkowski, Matthew A. (McDonnell Genome Institute) ;
Song, Yizhe (McDonnell Genome Institute) ;
Storrs, Erik P. (McDonnell Genome Institute) ;
Wendl, Michael C. (Washington University in St. Louis) ;
Zhang, Wubing (Dana-Farber Cancer Institute (Boston, Estats Units)) ;
Sibai, Mustafa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Serra, Victoria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Liang, Wen-Wei (McDonnell Genome Institute) ;
Terekhanova, Nadezhda V. (McDonnell Genome Institute) ;
Martins Rodrigues, Fernanda (McDonnell Genome Institute) ;
Clauser, Karl R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Heiman, David I. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhang, Qing (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Aguet, Francois (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Calinawan, Anna P. (Icahn School of Medicine at Mount Sinai) ;
Dhanasekaran, Saravana Mohan (University of Michigan) ;
Birger, Chet (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Satpathy, Shankha (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhou, Daniel Cui (McDonnell Genome Institute) ;
Wang, Liang-Bo (McDonnell Genome Institute) ;
Baral, Jessika (McDonnell Genome Institute) ;
Johnson, Jared L. (Weill Cornell Medicine) ;
Huntsman, Emily M. (Weill Cornell Medicine) ;
Pugliese, Pietro (University of Sannio (Benevento, Itàlia)) ;
Colaprico, Antonio (University of Miami Miller School of Medicine) ;
Iavarone, Antonio (University of Miami Miller School of Medicine) ;
Chheda, Milan G. (Washington University in St. Louis) ;
Ricketts, Christopher J. (National Institutes of Health) ;
Fenyö, David (NYU Grossman School of Medicine) ;
Payne, Samuel H. (Brigham Young University) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Gillette, Michael A. (Harvard Medical School) ;
Kumar-Sinha, Chandan (University of Michigan) ;
Lazar, Alexander (The University of Texas MD Anderson Cancer Center) ;
Cantley, Lewis (Weill Cornell Medicine) ;
Getz, Gad A. (Harvard Medical School) ;
Ding, Li (Siteman Cancer Center) ;
An, Eunkyung ;
Anurag, Meenakshi ;
Bavarva, Jasmin ;
Birrer, Michael J. ;
Calinawan, Anna ;
Ceccarelli, Michele ;
Chan, Daniel W. ;
Chinnaiyan, Arul M. ;
Cho, Hanbyul ;
Chowdhury, Shrabanti ;
Cieslik, Marcin P. ;
da Veiga Leprevost, Felipe ;
Day, Corbin ;
Domagalski, Marcin J. ;
Dou, Yongchao ;
Druker, Brian J. ;
Edwards, Nathan ;
Ellis, Matthew J. ;
Selvan, Myvizhi Esai ;
Foltz, Steven M. ;
Francis, Alicia ;
Gonzalez Robles, Tania J. ;
Gosline, Sara J. C. ;
Gümüş, Zeynep H. ;
Hiltke, Tara ;
Hong, Runyu ;
Hostetter, Galen ;
Hu, Yingwei ;
Huang, Chen ;
Huntsman, Emily ;
Jaehnig, Eric J. ;
Jewel, Scott D. ;
Ji, Jiayi ;
Jiang, Wen ;
Katsnelson, Lizabeth ;
Ketchum, Karen A. ;
Kolodziejczak, Iga ;
Lei, Jonathan T. ;
Liao, Yuxing ;
Lindgren, Caleb M. ;
Liu, Tao ;
Ma, Weiping ;
McKerrow, Wilson ;
Nesvizhskii, Alexey I. ;
Newton, Chelsea ;
Oldroyd, Robert ;
Omenn, Gilbert S. ;
Paulovich, Amanda G. ;
Petralia, Francesca ;
Reva, Boris ;
Rodland, Karin D. ;
Ruggles, Kelly V. ;
Rykunov, Dmitry ;
Savage, Sara R. ;
Schadt, Eric E. ;
Schnaubelt, Michael ;
Schraink, Tobias ;
Shi, Zhiao ;
Smith, Richard D. ;
Song, Xiaoyu ;
Tan, Jimin ;
Thangudu, Ratna R. ;
Tignor, Nicole ;
Wang, Joshua M. ;
Wang, Pei ;
Wang, Ying Cindy ;
Wen, Bo ;
Wiznerowicz, Maciej ;
Yi, Xinpei ;
Zhang, Bing ;
Zhang, Hui ;
Zhang, Xu ;
Zhang, Zhen ;
Universitat Autònoma de Barcelona
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. [...]
2023 - 10.1016/j.cell.2023.07.014
Cell, Vol. 186 Núm. 18 (31 2023) , p. 3921-3944.e25
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20.
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8 p, 1.2 MB |
AXL - a new player in resistance to HER2 blockade
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Adam-Artigues, Anna (INCLIVA Biomedical Research Institute) ;
Arenas, Enrique J (Centro de Investigación Biomédica en Red de Cáncer) ;
Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Prat, Aleix (SOLTI Breast Cancer Research Group) ;
Cejalvo, Juan Miguel (Vall d'Hebron Institut d'Oncologia)
HER2 is a driver in solid tumors, mainly breast, oesophageal and gastric cancer, through activation of oncogenic signaling pathways such as PI3K or MAPK. HER2 overexpression associates with aggressive disease and poor prognosis. [...]
2023 - 10.1016/j.ctrv.2023.102639
Cancer Treatment Reviews, Vol. 121 (december 2023) , p. 102639
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