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22.
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24 p, 4.1 MB |
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages
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Dupont, Maeva (Université de Toulouse) ;
Souriant, Shanti (Université de Toulouse) ;
Balboa, Luciana (Institute of Experimental Medicine-CONICET, National Academy of Medicine, Buenos Aires) ;
Vu Manh, Thien-Phong (Aix Marseille Univ, CNRS, INSERM, CIML, Marseille) ;
Pingris, Karine (Université de Toulouse) ;
Rousset, Stella (Université de Toulouse) ;
Cougoule, Céline (Université de Toulouse) ;
Rombouts, Yoann (Université de Toulouse) ;
Poincloux, Renaud (Université de Toulouse) ;
Ben Neji, Myriam (Université de Toulouse) ;
Allers, Carolina (Tulane University, Covington) ;
Kaushal, Deepak (Tulane University, Covington) ;
Kuroda, Marcelo J. (Tulane University, Covington) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sasiain, Maria del Carmen (Institute of Experimental Medicine-CONICET, National Academy of Medicine, Buenos Aires) ;
Maridonneau-Parini, Isabelle (Université de Toulouse) ;
Neyrolles, Olivier (Université de Toulouse) ;
Vérollet, Christel (Université de Toulouse) ;
Lugo-Villarino, Geanncarlo (Université de Toulouse)
While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. [...]
2020 -  10.7554/eLife.52535
eLife, Vol. 9 (march 2020)
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23.
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11 p, 2.5 MB |
Permanent control of HIV-1 pathogenesis in exceptional elite controllers : a model of spontaneous cure
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Casado, Concepcion (Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pernas, María (Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Tarancon-Diez, Laura (Universidad de Sevilla) ;
Rodriguez, Carmen (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Sanchez-Merino, Víctor (Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Vera, Mar (Centro Sanitario Sandoval, Hospital Clínico San Carlos) ;
Olivares, Isabel (Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
De Pablo-Bernal, Rebeca (Universidad de Sevilla) ;
Merino-Mansilla, Alberto (Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Del Romero, Jorge (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Lorenzo-Redondo, Ramon (Northwestern University Feinberg School of Medicine, Chicago, USA) ;
Ruiz-Mateos, Ezequiel (Universidad de Sevilla) ;
Salgado, María (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lopez-Galindez, Cecilio (Centro Nacional de Microbiología, Instituto de Salud Carlos III)
Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. [...]
2020 - 10.1038/s41598-020-58696-y
Scientific reports, Vol. 10 (february 2020)
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24.
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3 p, 1.9 MB |
SARS-CoV-2 interaction with Siglec-1 mediates trans -infection by dendritic cells
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Perez-Zsolt, Daniel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Muñoz-Basagoiti, Jordana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodon, Jordi (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Elosua-Bayes, Marc (Centre de Regulació Genòmica) ;
Raïch-Regué, Dàlia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Risco, Cristina (CSIC. Centro Nacional de Biotecnología) ;
Sachse, Martin (CSIC. Centro Nacional de Biotecnología) ;
Pino, Maria (Emory University. Division of Microbiology and Immunology) ;
Gumber, Sanjeev (Emory University. Division of Pathology) ;
Paiardini, Mirko (Emory University. Department of Pathology and Laboratory Medicine) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Muñiz-Trabudua, Xabier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tarrés-Freixas, Ferran (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guallar, Victor (Institució Catalana de Recerca i Estudis Avançats) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Telenti, Amalio (Scripps Research. Department of Integrative Structural and Computational Biology) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Clotet Sala, Bonaventura (Universitat de Vic) ;
Martínez Picado, Francisco Javier (Universitat de Vic) ;
Vergara-Alert, Júlia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
2021 - 10.1038/s41423-021-00794-6
Cellular and Molecular Immunology, Vol. 18 (november 2021) , p. 2676-2678
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25.
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17 p, 2.5 MB |
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
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Bastard, Paul (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Rosen, Lindsey B. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Zhang, Qian (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Michailidis, Eleftherios (The Rockefeller University. Laboratory of Virology and Infectious Disease) ;
Hoffmann, Hans-Heinrich (The Rockefeller University. Laboratory of Virology and Infectious Disease) ;
Zhang, Yu (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Dorgham, Karim (Sorbonne Université. Centre d'Immunologie et des Maladies Infectieuses) ;
Philippot, Quentin (University of Paris. Imagine Institute) ;
Rosain, Jérémie (University of Paris. Imagine Institute) ;
Béziat, Vivien (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Manry, Jeremy (University of Paris. Imagine Institute) ;
Shaw, Elana (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Haljasmägi, Liis (University of Tartu. Institute of Biomedicine and Translational Medicine) ;
Peterson, Pärt (University of Tartu. Institute of Biomedicine and Translational Medicine) ;
Lorenzo, Lazaro (University of Paris. Imagine Institute) ;
Bizien, Lucy (University of Paris. Imagine Institute) ;
Trouillet-Assant, Sophie (Lyon University. International Center of Research in Infectiology) ;
Dobbs, Kerry (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Almeida de Jesus, Adriana (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Belot, Alexandre (Lyon Immunopathology Federation. Hospices Civils de Lyon) ;
Kallaste, Anne (Internal Medicine Clinic. Tartu University Hospital) ;
Catherinot, Emilie (Hôpital Foch) ;
Tandjaoui-Lambiotte, Yacine (Avicenne Hospital. Assistance Publique Hôpitaux de Paris) ;
Le Pen, Jérémie (The Rockefeller University. Laboratory of Virology and Infectious Disease) ;
Kerner, Gaspard (University of Paris. Imagine Institute) ;
Bigio, Benedetta (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Seeleuthner, Yoann (University of Paris. Imagine Institute) ;
Yang, Rui (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Bolze, Alexandre (Helix) ;
Spaan, András N. (University Medical Center Utrecht) ;
Delmonte, Ottavia M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Abers, Michael S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Aiuti, Alessandro (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Casari, Giorgio (Medical Genetics. IRCCS Ospedale San Raffaele) ;
Lampasona, Vito (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Piemonti, Lorenzo (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Ciceri, Fabio (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Bilguvar, Kaya (Yale University School of Medicine. Department of Genetics) ;
Lifton, Richard P. (Rockefeller University. Laboratory of Human Genetics and Genomics) ;
Vasse, Marc (Consorcio Hospital. General Universitario) ;
Smadja, David M. (Paris University. European Georges Pompidou Hospital) ;
Migaud, Mélanie (University of Paris. Imagine Institute) ;
Hadjadj, Jérome (Hôpital Cochin. Department of Internal Medicine) ;
Terrier, Benjamin (Université de Paris. Department of Internal Medicine) ;
Duffy, Darragh (Pasteur Institute) ;
Quintana-Murci, Lluis (Institut Pasteur. Collège de France) ;
van de Beek, Diederik (Amsterdam UMC. University Medical Center) ;
Roussel, Lucie (McGill University Health Centre) ;
Vinh, Donald C. (McGill University Health Centre) ;
Tangye, Stuart (Garvan Institute of Medical Research (Darlinghurst, Austràlia)) ;
Haerynck, Filomeen (Ghent University Hospital. (Bèlgica)) ;
Dalmau, David (Fundació Docència i Recerca Mútua Terrassa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brodin, Petter (Karolinska Institutet (Estocolm, Suècia)) ;
Nussenzweig, Michel (Howard Hughes Medical Institute) ;
Boisson-Dupuis, Stephanie (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ;
Rodríguez-Gallego, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Vogt, Guillaume (University of Paris. Neglected Human Genetics Laboratory) ;
Mogensen, Trine Hyrup (Aarhus University) ;
Oler, Andrew J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ;
Gu, Jingwen (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ;
Burbelo, Peter D. (Division of Intramural Research. National Institute of Dental Craniofacial Research (NIDCR). NIH) ;
Cohen, Jeffrey I. (Laboratory of Infectious Diseases. Division of Intramural Research. NIAID. NIH) ;
Biondi, Andrea (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale) ;
Bettini, Laura Rachele (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale) ;
D'Angio, Mariella (University of Milano-Bicocca. Pediatric Department) ;
Bonfanti, Paolo (University of Milano-Bicocca. Department of Infectious Diseases) ;
Rossignol, Patrick (University of Lorraine. Plurithematic Clinical Investigation Centre) ;
Mayaux, Julien (APHP Pitié-Salpêtrière Hospital) ;
Rieux-Laucat, Frédéric (Laboratory of Immunogenetics of Pediatric Autoimmune Diseases. INSERM. UMR 1163. University of Paris. Imagine Institute) ;
Husebye, Eystein (Karolinska Institutet (Estocolm, Suècia). Department of Medicine) ;
Fusco, Francesca (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ;
Ursini, Matilde Valeria (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ;
Imberti, Luisa (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ;
Sottini, Alessandra (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ;
Paghera, Simone (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ;
Quiros-Roldan, Eugenia (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali di Brescia) ;
Rossi, Camillo (Direzione Sanitaria. ASST Spedali Civili di Brescia) ;
Castagnoli, Riccardo (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ;
Montagna, Daniela (Department of Clinical. Surgical. Diagnostic and Pediatric Sciences. University of Pavia) ;
Licari, Amelia (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ;
Marseglia, Gian Luigi (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ;
Duval, Xavier (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ;
Ghosn, Jade (Hôpital Bichat) ;
Tsang, John S. (Multiscale Systems Biology Section. Laboratory of Immune System Biology. NIAID. NIH) ;
Goldbach-Mansky, Raphaela (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Kisand, Kai (Institute of Biomedicine and Translational Medicine. University of Tartu) ;
Lionakis, Michail S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Puel, Anne (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Zhang, Shein-Ying (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Holland, Steven M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Gorochov, Guy (Département d'Immunologie. AP-HP. Hôpital Pitié-Salpétrière) ;
Jouanguy, Emmanuelle (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Rice, Charles M. (Laboratory of Virology and Infectious Disease. The Rockefeller University) ;
Cobat, Aurélie (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Notarangelo, Luigi (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Abel, Laurent (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ;
Su, Helen C. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Casanova, Jean-Laurent (Pediatric Hematology and Immunology Unit. Necker Hospital for Sick Children. AP-HP) ;
The University of Hong Kong
HGID Lab ;
The University of Hong Kong
NIAID-USUHS Immune Response to COVID Group ;
COVID Clinicians ;
COVID-STORM Clinicians ;
Imagine COVID Group ;
French COVID Cohort Study Group ;
The Milieu Intérieur Consortium ;
CoV-Contact Cohort ;
Amsterdam UMC Covid-19 Biobank ;
COVID Human Genetic Effort ;
Universitat Autònoma de Barcelona
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. [...]
2020 - 10.1126/science.abd4585
Science, Vol. 370 Núm. 6515 (september 2020) , p. eabd4585
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26.
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9 p, 3.7 MB |
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression
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Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lopez, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gómez Moruno, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Passaes, Caroline (Institut Pasteur) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Saez-Cirion, Asier (Institut Pasteur) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
BACKGROUND: Human genetic variation-mostly in the human leukocyte antigen (HLA) and C-C chemokine receptor type 5 (CCR5) regions-explains 25% of the variability in progression of human immunodeficiency virus (HIV) infection. [...]
2021 - 10.1093/cid/ciaa1047
Clinical Infectious Diseases, Vol. 72 Núm. 9 (april 2021) , p. e256-e264
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27.
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8 p, 759.1 KB |
Evidence for HIV-1 cure after CCR5 Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption : a case report
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Gupta, Ravindra Kumar (Africa Health Research Institute) ;
Peppa, Dimitra (UCL Great Ormond Street Institute of Child Health) ;
Hill, Alison L. (Harvard University. Department for Organismic and Evolutionary Biology) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pace, Matthew (Nuffield Department of Medicine, University of Oxford) ;
McCoy, Laura E. (Division of Infection and Immunity, University College London (UCL)) ;
Griffith, Sarah A. (Division of Infection and Immunity, University College London (UCL)) ;
Thornhill, John (Imperial College London) ;
Alrubayyi, Aljawharah (Nuffield Department of Medicine, University of Oxford) ;
Huyveneers, Laura E. P. (Department of Medical Microbiology, University Medical Center) ;
Nastouli, Eleni (UCL Great Ormond Street Institute of Child Health) ;
Grant, Paul (Department of Virology, UCL Hospitals) ;
Edwards, Simon G.. (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ;
Innes, Andrew J. (Hammersmith Hospital (Londres)) ;
Frater, John (Oxford National Institute for Health Research Biomedical Research Centre) ;
Nijhuis, Monique (Department of Medical Microbiology, University Medical Center) ;
Wensing, Anne Marie J. (Department of Medical Microbiology, University Medical Center) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olavarria, Eduardo (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ;
Universitat Autònoma de Barcelona
The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5 Δ32/Δ32); remission was reported at 18 months after analytical treatment interruption (ATI). [...]
2020 - 10.1016/S2352-3018(20)30069-2
The lancet. HIV, Vol. 7 (march 2020) , p. e340-e347
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28.
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25 p, 3.6 MB |
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
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Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ganoza, C. (Alberto Hurtado School of Medicine. Universidad Peruana Cayetano Heredia) ;
Sanchez, J. (Centro de Investigaciones Tecnológicas. Biomédicas y Medioambientales. CITBM) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. [...]
2020 - 10.1371/JOURNAL.PPAT.1008678
PLOS pathogens, Vol. 16 Núm. 8 (june 2020) , p. e1008678
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29.
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17 p, 2.5 MB |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
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Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Drobniewski, Francis (Imperial College) ;
Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ong, Ruo-Yan (University of Dundee) ;
Luquín Fernández, Marina (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cardona, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Furrer, Hansjakob (University of Bern) ;
Günthard, Huldrych F. (University of Zurich) ;
Crocker, Paul R. (University of Dundee) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fellay, Jacques (Lausanne University Hospital) ;
McLaren, Paul J. (University of Manitoba) ;
Telenti, Amalio (The Scripps Research Institute) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)
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30.
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13 p, 912.5 KB |
Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans -Infection Through Recognition of Viral Membrane Gangliosides
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Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodriguez-Plata, Maria T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Zangger, Nadine (Lausanne University Hospital) ;
Erikson, Elina (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Keppler, Oliver T. (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Telenti, Amalio (Lausanne University Hospital) ;
Kräusslich, Hans-Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
The novel dendritic cell receptor Siglec-1 binds sialyllactose moieties on HIV-1 membrane gangliosides, thereby enhancing HIV-1 transinfection. Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. [...]
2012 - 10.1371/journal.pbio.1001448
PLoS biology, Vol. 10 (december 2012)
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31.
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12 p, 1.1 MB |
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
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Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Valero, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Monceaux, Valérie (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Huot, Nicolas (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Leal, Lorna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
González Soler, Victoria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Cao, María (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Müller-Trutwin, Michaela (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Sáez-Cirión, Asier (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
García, Felipe (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV + individuals could naturally also harbour low viral reservoirs. [...]
2020 - 10.1016/j.ebiom.2020.102830
EBioMedicine, Vol. 57 (june 2020)
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