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Artículos Encontrados 747 registros  inicioanterior220 - 229siguientefinal  ir al registro: La búsqueda tardó 0.01 segundos. 
220.
22 p, 2.7 MB Somatic hypomethylation of pericentromeric sst1 repeats and tetraploidization in human colorectal cancer cells / González Fernández, Beatriz (Institut Germans Trias i Pujol) ; Navarro Jiménez, Maria (Institut Germans Trias i Pujol) ; Alonso De Gennaro, María José (Institut Germans Trias i Pujol) ; Jansen, Sanne Marcia (Institut Germans Trias i Pujol) ; Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Perucho, Manuel (Sanford Burnham Prebys Medical Discovery Institute (SBP)) ; Alonso, Sergio (Institut Germans Trias i Pujol)
Somatic DNA hypomethylation and aneuploidy are hallmarks of cancer, and there is evidence for a causal relationship between them in knockout mice but not in human cancer. The non-mobile pericentromeric repetitive elements SST1 are hypomethylated in about 17% of human colorectal cancers (CRC) with some 5-7% exhibiting strong age-independent demethylation. [...]
2021 - 10.3390/cancers13215353
Cancers, Vol. 13 Núm. 21 (11-1 2021) , p. 5353  
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221.
13 p, 1.2 MB Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA / Ruiz Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer) ; Rodríguez Casanova, Aitor (Universidade de Santiago de Compostela) ; Costa-Fraga, Nicolás (Universidade de Santiago de Compostela) ; Bao Caamano, Aida (Universidade de Santiago de Compostela) ; Álvarez Castro, Ana (Complejo Hospitalario Universitario de Santiago de Compostela) ; Carreras Presas, Martín (Complejo Hospitalario Universitario de Santiago de Compostela) ; Brozos Vázquez, Elena (Complejo Hospitalario Universitario de Santiago de Compostela) ; Vidal Insua, Yolanda (Complejo Hospitalario Universitario de Santiago de Compostela) ; Vázquez Rivera, Francisca (Complejo Hospitalario Universitario de Santiago de Compostela) ; Candamio Folgar, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ; Mosquera Presedo, Manuel (Universidade de Santiago de Compostela) ; Lago Lestón, Ramón M. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Vázquez Bueno, José Ángel (Complejo Hospitalario Universitario de Ferrol) ; Sanz Pamplona, Rebeca (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Moreno Aguado, Víctor (Universitat de Barcelona. Departament de Ciències Clíniques) ; Goel, Ajay (City of Hope Comprehensive Cancer Center) ; Castillo, Lourdes (Advanced Marker Discovery) ; Martín, Ana C. (Advanced Marker Discovery) ; Arroyo, Rocío (Advanced Marker Discovery) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Crujeiras, Ana B. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; López López, Rafael (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Diaz-Lagares, Angel (Complejo Hospitalario Universitario de Santiago de Compostela)
Background: Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated the clinical utility of promoter methylation of the long noncoding RNA LINC00473 as a noninvasive biomarker to detect colorectal cancer and associated precancerous lesions. [...]
2022 - 10.1186/s13148-022-01302-x
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 86  
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222.
16 p, 1.0 MB The role of macroh2a histone variants in cancer / Hsu, Chen-Jen (Internal Medicine C. Greifswald University Medicine) ; Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Heidel, Florian H. (Leibniz Institute on Aging. Fritz-Lipmann Institute)
The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. [...]
2021 - 10.3390/cancers13123003
Cancers, Vol. 13 Núm. 12 (february 2021) , p. 3003  
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223.
15 p, 620.3 KB Clear Improvement in Real-World Chronic Myeloid Leukemia Survival : A Comparison With Randomized Controlled Trials / Vener, Claudia (University of Milan) ; Rossi, Silvia (Istituto Superiore di Sanità) ; Minicozzi, Pamela (London School of Hygiene and Tropical Medicine) ; Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Poirel, Hélène A. (Belgian Cancer Registry) ; Maynadié, Marc (Côte d'Or Hematological Malignancies Registry) ; Troussard, Xavier (Centre Hospitalier Universitaire (CHU) de Caen) ; Pravettoni, Gabriella (University of Milan) ; De Angelis, Roberta (Istituto Superiore di Sanità) ; Sant, Milena (Istituto Nazionale dei Tumori)
Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. [...]
2022 - 10.3389/fonc.2022.892684
Frontiers in Oncology, Vol. 12 (14 2022) , p. 892684  
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224.
14 p, 2.9 MB GATA2 deficiency and MDS/AML : Experimental strategies for disease modelling and future therapeutic prospects / Kotmayer, Lili (Semmelweis University) ; Romero-Moya, Damià (Institut d'Investigació Biomèdica de Bellvitge) ; Marin-Béjar, Oskar (Institut d'Investigació Biomèdica de Bellvitge) ; Kozyra, Emilia (University of Freiburg) ; Català, Albert (Hospital Sant Joan de Deu) ; Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Wlodarski, Marcin W. (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Bödör, Csaba (Semmelweis University) ; Giorgetti, Alessandra (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental)
The importance of predisposition to leukaemia in clinical practice is being increasingly recognized. This is emphasized by the establishment of a novel WHO disease category in 2016 called "myeloid neoplasms with germline predisposition". [...]
2022 - 10.1111/bjh.18330
British Journal of Haematology, Vol. 199 Núm. 4 (november 2022) , p. 482-495  
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225.
25 p, 1.2 MB Circulating cell-free dna in breast cancer : Searching for hidden information towards precision medicine / Panagopoulou, Maria (Democritus University of Thrace(DUTH)) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Chatzaki, Ekaterini (Democritus University of Thrace(DUTH))
Breast cancer (BC) is a leading cause of death between women. Mortality is significantly raised due to drug resistance and metastasis, while personalized treatment options are obstructed by the limitations of conventional biopsy follow-up. [...]
2021 - 10.3390/cancers13040728
Cancers, Vol. 13 Núm. 4 (february 2021) , p. 1-26  
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226.
16 p, 715.0 KB A somatic mutation in moesin drives progression into acute myeloid leukemia / Yuan, Ouyang. (Lund University) ; Ugale, Amol. (The University of Vienna) ; de Marchi, Tommaso (Lund University) ; Anthonydhason, Vimala (Sahlgrenska Center for Cancer Research. University of Gothenburg) ; Konturek-Ciesla, Anna (Lund University) ; Wan, Haixia (Lund University) ; Eldeeb, Mohamed (Lund University) ; Drabe, Caroline (Lund University) ; Jassinskaja, Maria (University of York) ; Hansson, Jenny (Lund University) ; Hidalgo, Isabel (Lund University) ; Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Cammenga, Jörg (Lund University) ; Magee, Jeffrey A. (Washington University School of Medicine) ; Niméus, Emma (Skåne University Hospital (Suècia)) ; Bryder, David (Lund University) ; Universitat Autònoma de Barcelona
2022 - 10.1126/sciadv.abm9987
Science advances, Vol. 8 Núm. 16 (april 2022) , p. eabm9987  
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227.
18 p, 886.7 KB Cancer Survival in Adults in Spain : A Population-Based Study of the Spanish Network of Cancer Registries (REDECAN) / Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra) ; Molinuevo, Amaia (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Salmerón, Diego (Universidad de Murcia. Departamento de Ciencias Sociosanitarias) ; Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Carulla, Marià (Universitat Rovira i Virgili. Facultat de Medicina i Ciències de la Salut) ; Chirlaque, María-Dolores (Murcia Regional Health Council) ; Rodríguez Camblor, Marta (Public Health Directorate of Asturias) ; Alemán, Araceli (Canary Health Service) ; Rojas, Dolores (Canary Health Service) ; Vizcaino Batllés, Ana (Generalitat Valenciana) ; Chico, Matilde (Health and Social Welfare Authority (Ciutat Real)) ; Jiménez Chillarón, Rosario (Health and Social Welfare Authority (Conca)) ; López de Munain, Arantza (Basque Country Health Department) ; de Castro, Visitación (Basque Country Health Department) ; Sánchez, María-José (Universidad de Granada) ; Ramalle-Gómara, Enrique (La Rioja Regional Health Authority) ; Franch, Paula (Balearic Islands Public Health Department) ; Galceran, Jaume (Universitat Rovira i Virgili) ; Ardanaz, Eva (Instituto de Investigación Sanitaria de Navarra) ; Universitat Autònoma de Barcelona
The assessment of cancer survival at the population level is essential for monitoring progress in cancer control. We aimed to assess cancer survival and its trends in adults in Spain. Individual records of 601,250 adults with primary cancer diagnosed during 2002-2013 and followed up to 2015 were included from 13 population-based cancer registries. [...]
2022 - 10.3390/cancers14102441
Cancers, Vol. 14 Núm. 10 (5-2 2022) , p. 2441  
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228.
12 p, 339.3 KB Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC : Results From the Phase 3 TAHOE Study / Blackhall, Fiona (Department of Medical Oncology. The Christie National Health Service (NHS) Foundation Trust) ; Jao, K. (Department of Hematology and Oncology. Hopital du Sacre Coeur Montreal) ; Greillier, L. (Multidisciplinary Oncology and Therapeutic Innovations Department. Centre de Recherche en Cancérologie de Marseille (CRCM). Centre National de la Recherche Scientifique (CNRS). Institut National de la Santé et de la Recherche Médicale (INSERM). Assistance Publique-Hopitaux de Marseille (APHM). Aix-Marseille University) ; Cho, B.C. (Division of Medical Oncology. Department of Internal Medicine. Yonsei Cancer Center. Yonsei University College of Medicine) ; Penkov, K. (Private Medical Institution Euromedservice) ; Reguart, Noemi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Nackaerts, K. (Department of Pulmonology and Respiratory Oncology. University Hospital Leuven. Katholieke Universiteit (KU) Leuven) ; Syrigos, K. (Department of Medicine. National and Kapodistrian University of Athens) ; Hansen, K. (Odense University Hospital (Dinamarca)) ; Schuette, W. (2nd Medical Department. Krankenhaus Martha-Maria Halle-Doelau. Halle) ; Cetnar, J. (Department of Medicine. Oregon Health & Science University) ; Cappuzzo, F. (Department of Medical Oncology. Istituto Nazionale Tumori Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)) ; Okamoto, I. (Department of Medical Oncology. Kyushu University Hospital) ; Erman, M. (Department of Medical Oncology. Cancer Institute. Hacettepe University) ; Langer, S.W. (Rigshospitalet. University of Copenhagen) ; Kato, T. (Department of Thoracic Oncology. Kanagawa Cancer Center) ; Groen, H. (Department of Pulmonary Disease. University Medical Center Groningen. University of Groningen) ; Sun, Z. (AbbVie. Inc.) ; Luo, Y. (AbbVie. Inc.) ; Tanwani, P. (AbbVie. Inc.) ; Caffrey, L. (AbbVie. Inc.) ; Komarnitsky, P. (AbbVie. Inc.) ; Reinmuth, N. (Thoracic Oncology Department. Asklepios Fachkliniken München-Gauting)
Introduction: DLL3, an atypical Notch ligand, is expressed in SCLC tumors but is not detectable in normal adult tissues. Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate containing a DLL3-targeting antibody tethered to a cytotoxic agent pyrrolobenzodiazepine by means of a protease-cleavable linker. [...]
2021 - 10.1016/j.jtho.2021.02.009
Journal of Thoracic Oncology, Vol. 16 Núm. 9 (september 2021) , p. 1547-1558  
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229.
15 p, 1.1 MB Values and preferences related to cancer risk among red and processed meat eaters : A pilot cross-sectional study with semi-structured interviews / Howatt, Victoria (Department of Community Health and Epidemiology. Dalhousie University) ; Prokop-dorner, A. (Chair of Epidemiology and Preventive Medicine. Department of Medical Sociology. Jagiellonian University Medical College) ; Valli, Claudia (Institut d'Investigació Biomèdica Sant Pau) ; Zajac, Joanna (Department of Hygiene and Dietetics. Epidemiology and Preventive Medicine. Jagiellonian University Medical College) ; Bala, Malgorzata M.. (Jagiellonian University Medical College, Krakow) ; Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ; Guyatt, G.H. (Department of Medicine. McMaster University) ; Johnston, Bradley C (Departments of Nutrition. Epidemiology and Biostatistics. Texas A&M University) ; Universitat Autònoma de Barcelona
Introduction: Over the last decade, the possible impact of meat intake on overall cancer incidence and mortality has received considerable attention, and authorities have recommended decreasing consumption; however, the benefits of reducing meat consumption are small and uncertain. [...]
2021 - 10.3390/foods10092182
Foods, Vol. 10 Núm. 9 (september 2021) , p. 2182  
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Artículos : Encontrados 747 registros   inicioanterior220 - 229siguientefinal  ir al registro:
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