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12 p, 2.6 MB Ras activation is a key event in activity-dependent survival of cerebellar granule neurons / Xifro Collsamata, Francesc Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Neuronal activity promotes the survival of cerebellar granule neurons (CGNs) during the postnatal development of cerebellum. CGNs that fail to receive excitatory inputs will die by apoptosis. This process could be mimicked in culture by exposing CGNs to either a physiological concentration of KCl (5 mm or K5) plus N-methyl-d-aspartate (NMDA) or to 25 mm KCl (K25). [...]
2014 - 10.1074/jbc.M113.536375
Journal of biological chemistry, Vol. 289, No. 12 (March 2014) , p. 8462-847  
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