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16 p, 2.3 MB SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina / Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Simonet, N. G. (Institut d'Investigació Biomèdica de Bellvitge) ; Chahar, S. (Montpellier Institute of Molecular Genetics (IGMM). CNRS. University of Montpellier) ; Kane-Goldsmith, N. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Newkirk, S. J. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ; Lee, S. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ; Xing, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Verzi, M. P. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; An, W. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ; Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Tischfield, J. A. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Serrano, L. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Universitat Autònoma de Barcelona
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. [...]
2019 - 10.1093/nar/gkz519
Nucleic acids research, Vol. 47 Núm. 15 (january 2019) , p. 7870-7885  
Detailed record - Creative Commons

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