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12 p, 919.1 KB A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation / Castro, Jessica (Universitat de Girona. Departament de Biologia) ; Ribó i Panosa, Marc (Universitat de Girona. Departament de Biologia) ; Navarro Cantero, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Nogués i Bara, M. Victòria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Vilanova i Brugués, Maria (Universitat de Girona. Departament de Biologia) ; Benito i Mundet, Antoni (Universitat de Girona. Departament de Biologia)
Background: Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effects, presents synergism with several kinds of anticancer drugs and is currently in phase II/III of its clinical trial as an anticancer drug against different types of cancer. [...]
2011 - 10.1186/1471-2407-11-9
BMC Cancer, Vol. 11, N. 9 (January 2011) , p. 1-12  

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