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Published articles	3 records found	Search took 0.02 seconds.

11 p, 2.4 MB

The role of Cysteine 6.47 in class A GPCRs / Olivella, Mireia (Universitat de Vic. Departament de Biologia de Sistemes) ; Caltabiano, Gianluigi 1978- (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional)
Background: The CWxP motif of transmembrane helix 6 (x: any residue) is highly conserved in class A GPCRs. Within this motif, W6. 48 is a big star in the theory of the global "toggle switch" because of its key role in the activation mechanism of GPCRs upon ligand binding. [...]
2013 - DOI (Digital Object Identifier)

10.1186/1472-6807-13-3
BMC Structural biology, Vol. 13, Núm. 3 (March 2013) , p. 1-10

2 documents

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11 p, 1.8 MB

DockAnalyse : an application for the analysis of protein-protein interactions / Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Delicado, Pedro (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ; Gómez, Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bonàs, Sílvia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Background: Is it possible to identify what the best solution of a docking program is? The usual answer to this question is the highest score solution, but interactions between proteins are dynamic processes, and many times the interaction regions are wide enough to permit protein-protein interactions with different orientations and/or interaction energies. [...]
2010 - DOI (Digital Object Identifier)

10.1186/1472-6807-10-37
BMC Structural biology, Vol. 10, N. 37 (October 2010) , p.

2 documents

Detailed record -

14 p, 1.9 MB

Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery / Panjkovich, Alejandro (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: With the classical, active-site oriented drug-development approach reaching its limits, protein ligand-binding sites in general and allosteric sites in particular are increasingly attracting the interest of medicinal chemists in the search for new types of targets and strategies to drug development. [...]
2010 - DOI (Digital Object Identifier)

10.1186/1472-6807-10-9
BMC Structural biology, Vol. 10, Núm. 9 (March 2010) , p. 9-9

Detailed record -

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