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10 p, 2.4 MB Ion-dependent slow protein release from in vivo disintegrating micro-granules / Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ; Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be clustered in form of chemically pure and mechanically stable micron-scale particles. Under physiological conditions, these materials act as self-disintegrating protein depots for the progressive release of the forming polypeptide, with potential applications in protein drug delivery, diagnosis, or theragnosis. [...]
2021 - 10.1080/10717544.2021.1998249
Drug Delivery, Vol. 28, Issue 1 (November 2021) , p. 2383-2391  
Detailed record - Creative Commons

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