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17 p, 3.1 MB Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci / Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ortiz-Fernández, Lourdes (Instituto de Parasitología y Biomedicina "López-Neyra") ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Javierre, B. M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; López-Isac, E. (Instituto de Parasitología y Biomedicina "López-Neyra") ; Guillén-Del-Castillo, A. (Hospital Universitari Vall d'Hebron) ; Simeón-Aznar, C. P. (Hospital Universitari Vall d'Hebron) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ; Universitat Autònoma de Barcelona
Background: Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. [...]
2020 - 10.1186/s13073-020-00779-6
Genome Medicine, Vol. 12 Núm. 1 (25 2020) , p. 81  
Detailed record - Creative Commons

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