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22 p, 4.5 MB Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state / Kisby, Thomas (University of Manchester. Nanomedicine Lab) ; de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ; Stylianou, Maria (University of Manchester. Nanomedicine Lab) ; Cossu, Giulio (University of Manchester. Division of Cell Matrix Biology and Regenerative Medicine) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
In contrast to mammals, lower vertebrates are capable of extraordinary myocardial regeneration thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and proliferation. Somatic cells can be temporarily reprogrammed to a proliferative, dedifferentiated state through forced expression of Oct3/4, Sox2, Klf4 and c-Myc (OSKM). [...]
2021 - 10.1371/journal.pone.0251054
PloS one, Vol. 16, Issue 5 (May 2021) , p. e0251054  

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