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12 p, 3.9 MB |
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
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Hendriksen, Rene S. (National Food Institute. Technical University of Denmark) ;
Munk, Patrick (Technical University of Denmark. National Food Institute.) ;
Njage, Patrick (Technical University of Denmark. National Food Institute.) ;
van Bunnik, Bram (University of Edinburgh. Usher Institute.) ;
McNally, Luke (University of Edinburgh. Centre for Synthetic and Systems Biology. School of Biological Sciences.) ;
Lukjancenko, Oksana (Technical University of Denmark. National Food Institute.) ;
Röder, Timo (Technical University of Denmark. National Food Institute.) ;
Nieuwenhuijse, David (Erasmus Medical Center. Viroscience.) ;
Pedersen, Susanne Karlsmose (Technical University of Denmark. National Food Institute.) ;
Kjeldgaard, Jette (Technical University of Denmark. National Food Institute.) ;
Kaas, Rolf S. (Technical University of Denmark. National Food Institute.) ;
Clausen, Philip Thomas Lanken Conradsen (Technical University of Denmark. National Food Institute.) ;
Vogt, Josef Korbinian (Technical University of Denmark. National Food Institute.) ;
Leekitcharoenphon, Pimlapas (Technical University of Denmark. National Food Institute.) ;
van de Schans, Milou G. M. (RIKILT Wageningen University and Research) ;
Zuidema, Tina (RIKILT Wageningen University and Research) ;
de Roda Husman, Ana Maria (National Institute for Public Health and the Environment (RIVM)) ;
Rasmussen, Simon (Technical University of Denmark. Department of Bio and Health Informatics.) ;
Petersen, Bent (Technical University of Denmark. Department of Bio and Health Informatics.) ;
Bego, Artan (Institute of Public Health) ;
Rees, Charlotte (Melbourne Water Corporation) ;
Cassar, Susan (Melbourne Water Corporation) ;
Coventry, Kris (Melbourne Water Corporation) ;
Collignon, Peter (Canberra Hospital) ;
Allerberger, Franz (Austrian Agency for Health and Food Safety (AGES)) ;
Rahube, Teddie O. (Botswana International University of Science and Technology) ;
Oliveira, Guilherme (Vale Institute of Technology. Sustainable Development) ;
Ivanov, Ivan (National Center of Infectious and Parasitic Diseases) ;
Vuthy, Yith (Institut Pasteur du Cambodge) ;
Sopheak, Thet (Institut Pasteur du Cambodge) ;
Yost, Christopher K. (University of Regina) ;
Ke, Changwen (Guangdong Provincial Center for Disease Control and Prevention) ;
Zheng, Huanying (Guangdong Provincial Center for Disease Control and Prevention) ;
Baisheng, Li (Guangdong Provincial Center for Disease Control and Prevention) ;
Jiao, Xiaoyang (Shantou University Medical College) ;
Donado-Godoy, Pilar (Corporacion Colombiana de Investigacion Agropecuaria (AGROSAVIA)) ;
Coulibaly, Kalpy Julien (Institut Pasteur de Côte d'Ivoire) ;
Jergović, Matijana (Andrija Stampar Teaching Institute of Public Health) ;
Hrenovic, Jasna (University of Zagreb) ;
Karpíšková, Renáta (Veterinary Research Institute) ;
Villacis, Jose Eduardo (Instituto Nacional de Investigación en Salud Pública-INSPI (CRNRAM)) ;
Legesse, Mengistu (Addis Ababa University) ;
Eguale, Tadesse (Addis Ababa University) ;
Heikinheimo, Annamari (University of Helsinki) ;
Malania, Lile (National Center for Disease Control and Public Health) ;
Nitsche, Andreas (Robert Koch Institute) ;
Brinkmann, Annika (Robert Koch Institute) ;
Saba, Courage Kosi Setsoafia (University for Development Studies) ;
Kocsis, Bela (Semmelweis University. Institute of Medical Microbiology) ;
Solymosi, Norbert (University of Veterinary Medicine) ;
Thorsteinsdottir, Thorunn R. (University of Iceland. Institute for Experimental Pathology) ;
Hatha, Abdulla Mohamed (Cochin University of Science and Technology) ;
Alebouyeh, Masoud (Shahid Beheshti University of Medical Sciences. Foodborne and Waterborne Diseases Research center) ;
Morris, Dearbhaile (National University of Ireland Galway) ;
Cormican, Martin (National University of Ireland Galway) ;
O'Connor, Louise (National University of Ireland Galway) ;
Moran-Gilad, Jacob (Ben Gurion University of the Negev and Ministry of Health. School of Public Health) ;
Alba, Patricia (Istituto Zooprofilattico Sperimentale del Lazio e della Toscana) ;
Battisti, Antonio (Istituto Zooprofilattico Sperimentale del Lazio e della Toscana) ;
Shakenova, Zeinegul (National Center of Expertise) ;
Kiiyukia, Ciira (Mount Kenya University) ;
Ng'eno, Eric (Kenya Medical Research Institute) ;
Raka, Lul (University of Prishtina "Hasan Prishtina" & National Institute of Public Health of Kosovo) ;
Avsejenko, Jeļena (Institute of Food Safety) ;
Bērziņš, Aivars (Institute of Food Safety) ;
Bartkevics, Vadims (Institute of Food Safety) ;
Penny, Christian (Luxembourg Institute of Science and Technology) ;
Rajandas, Heraa (Environmental Health Directorate) ;
Parimannan, Sivachandran (AIMST University (Malàisia). Centre of Excellence for Omics-Driven Computational Biodiscovery) ;
Haber, Malcolm Vella (Agriculture and Forestry University) ;
Pal, Pushkar (University of Otago) ;
Jeunen, Gert-Jan (University of Ibadan) ;
Gemmell, Neil (University of Ibadan) ;
Fashae, Kayode (VEAS) ;
Holmstad, Rune (Aga Khan University) ;
Hasan, Rumina (National Institute of Health) ;
Shakoor, Sadia (National Institute of Health) ;
Rojas, Maria Luz Zamudio (National Veterinary Research Institute) ;
Wasyl, Dariusz (Institute of Public Health of the Republic of Macedonia) ;
Bosevska, Golubinka (State Medical and Pharmaceutical University) ;
Kochubovski, Mihail (State Medical and Pharmaceutical University) ;
Radu, Cojocaru (Institut Pasteur de Dakar) ;
Gassama, Amy (Institute of Veterinary Medicine of Serbia) ;
Radosavljevic, Vladimir (Nanyang Technological University. Singapore Centre for Environmental Life Sciences Engineering (SCELSE)) ;
Wuertz, Stefan (Nanyang Technological University Food Technology Centre (NAFTEC)) ;
Zuniga-Montanez, Rogelio (Nanyang Technological University Food Technology Centre (NAFTEC)) ;
Tay, Moon Y. F. (Public Health Authority of the Slovak Republic) ;
Gavačová, Dagmar (National Laboratory of Health. Environment and Food) ;
Pastuchova, Katarina (National Laboratory of Health. Environment and Food) ;
Truska, Peter (National Laboratory of Health. Environment and Food) ;
Trkov, Marija (Daspoort Waste Water Treatment Works) ;
Esterhuyse, Kerneels (University of the Witwatersrand) ;
Keddy, Karen (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Cerdà-Cuéllar, Marta (Medical Research Institute) ;
Pathirage, Sujatha (Swedish University of Agricultural Sciences) ;
Norrgren, Leif (The Sahlgrenska Academy at the University of Gothenburg) ;
Örn, Stefan (The Sahlgrenska Academy at the University of Gothenburg) ;
Larsson, D. G. Joakim (Ara Region Bern Ag) ;
Heijden, Tanja Van der (Kilimanjaro Clinical Research Institute) ;
Kumburu, Happiness Houka (National Public Health Laboratories) ;
Sanneh, Bakary (National Institute of Hygiene) ;
Bidjada, Pawou (Agence de Médecine Préventive) ;
Njanpop-Lafourcade, Berthe-Marie (Agence Médecine Préventive) ;
Nikiema-Pessinaba, Somtinda Christelle (Public Health Institution of Turkey) ;
Levent, Belkis (University of Washington) ;
Meschke, John Scott (Institute of Public Health in Ho Chi Minh City) ;
Beck, Nicola Koren (Institute of Public Health in Ho Chi Minh City) ;
Van, Chinh Dang (University of Zambia) ;
Phuc, Nguyen Do (University of Zambia) ;
Tran, Doan Minh Nguyen (University of Zambia) ;
Kwenda, Geoffrey (University of N'Djamena) ;
Tabo, Djim-adjim (Norwegian Institute of Public Health) ;
Wester, Astrid Louise (Universidad Católica del Maule) ;
Cuadros-Orellana, Sara (Universidad Católica del Maule. Centro de Biotecnología de los Recursos Naturales) ;
Amid, C. (European Molecular Biology Laboratory. European Bioinformatics Institute) ;
Cochrane, G. (European Molecular Biology Laboratory. European Bioinformatics Institute) ;
Sicheritz-Ponten, T. (AIMST University (Malàisia). Centre of Excellence for Omics-Driven Computational Biodiscovery) ;
Schmitt, H. (National Institute for Public Health and the Environment (RIVM)) ;
Alvarez, J. R. M. (World Health Organization) ;
Aidara-Kane, A. (World Health Organization) ;
Pamp, S. J. (Technical University of Denmark. National Food Institute.) ;
Lund, O. (Technical University of Denmark. Department of Bio and Health Informatics.) ;
Hald, T. (Technical University of Denmark. National Food Institute.) ;
Woolhouse, M. (University of Edinburgh. Usher Institute) ;
Koopmans, M. P. (Erasmus Medical Center. Viroscience) ;
Vigre, H. (Technical University of Denmark. National Food Institute.) ;
Petersen, T. N. (Technical University of Denmark. National Food Institute.) ;
Aarestrup, Frank (Technical University of Denmark. National Food Institute.)
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. [...]
2019 -  10.1038/s41467-019-08853-3
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 1124
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17 p, 4.3 MB |
Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site
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Streltsov, Victor A. (Commonwealth Scientific and Industrial Research Organisation, Materials Science and Engineering) ;
Luang, Sukanya (University of Adelaide. School of Agriculture, Food and Wine) ;
Peisley, Alys (Commonwealth Scientific and Industrial Research Organisation, Materials Science and Engineering) ;
Varghese, Joseph N. (Commonwealth Scientific and Industrial Research Organisation. Materials Science and Engineering) ;
Ketudat Cairns, James R. (Suranaree University of Technology. School of Chemistry) ;
Fort, Sebastien (University Grenoble Alpes. Centre de Recherches sur les Macromolécules Végétales) ;
Hijnen, Marcel (GE Healthcare Life Sciences) ;
Tvaroška, Igor (Slovak Academy of Sciences. Institute of Chemistry) ;
Ardá, Ana (CIC bioGUNE) ;
Jiménez Barbero, Jesús (CIC bioGUNE) ;
Alfonso Prieto, Mercedes (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ;
Rovira, Carme (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ;
Mendoza, Fernanda (Universitat Autònoma de Barcelona. Departament de Química) ;
Tiessler Sala, Laura. (Universitat Autònoma de Barcelona. Departament de Química) ;
Sánchez-Aparicio, José-Emilio (Universitat Autònoma de Barcelona. Departament de Química) ;
Rodríguez-Guerra Pedregal, Jaime (Universitat Autònoma de Barcelona. Departament de Química) ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Hrmova, Maria (University of Adelaide. School of Agriculture, Food and Wine)
Substrates associate and products dissociate from enzyme catalytic sites rapidly, which hampers investigations of their trajectories. The high-resolution structure of the native Hordeum exo-hydrolase HvExoI isolated from seedlings reveals that non-covalently trapped glucose forms a stable enzyme-product complex. [...]
2019 - 10.1038/s41467-019-09691-z
Nature communications, Vol. 10 (2019) , p. 2222
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3.
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11 p, 3.2 MB |
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
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Pascual-García, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bonfill-Teixidor, Ester (Vall d'Hebron Institut d'Oncologia) ;
Planas-Rigol, Ester (Vall d'Hebron Institut d'Oncologia) ;
Rubio-Perez, Carlota (Vall d'Hebron Institut d'Oncologia) ;
Iurlaro, Raffaella (Vall d'Hebron Institut d'Oncologia) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Cuartas, Isabel (Vall d'Hebron Institut d'Oncologia) ;
Sala-Hojman, Ada (Vall d'Hebron Institut d'Oncologia) ;
Escudero, Laura (Vall d'Hebron Institut d'Oncologia) ;
Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ;
Huber-Ruano, Isabel (Vall d'Hebron Institut d'Oncologia) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Pedrosa, Leire (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Marques, Carlota (Centro Nacional de Investigaciones Oncológicas) ;
Braña, Irene (Vall d'Hebron Institut d'Oncologia) ;
Garralda, Elena (Vall d'Hebron Institut d'Oncologia) ;
Vieito, María (Vall d'Hebron Institut d'Oncologia) ;
Squatrito, Juan (Centro Nacional de Investigaciones Oncológicas) ;
Pineda, Estela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Graus Ribas, Francesc (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Espejo, Carmen (Universitat Autònoma de Barcelona) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Tabernero, Josep (Universitat Autònoma de Barcelona) ;
Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats)
Cancer response to immunotherapy depends on the infiltration of CD8 T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. [...]
2019 - 10.1038/s41467-019-10369-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 2416
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13 p, 6.7 MB |
Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
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Hogarth, Marshall W. (Research Center for Genetic Medicine. Children's Research Institute. Children's National Health System) ;
Defour, Aurelia (Research Center for Genetic Medicine. Children's Research Institute. Children's National Health System) ;
Lazarski, Christopher (Children's Research Institute. Children's National Health System) ;
Gallardo, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Manera, Jordi Diaz (Institut d'Investigació Biomèdica Sant Pau) ;
Partridge, Terence A. (Department of Genomics and Precision Medicine. George Washington University School of Medicine) ;
Nagaraju, Kanneboyina (Department of Pharmaceutical Sciences. School of Pharmacy and Pharmaceutical Sciences. Binghamton University) ;
Jaiswal, JK. (Department of Genomics and Precision Medicine. George Washington University School of Medicine) ;
Universitat Autònoma de Barcelona
Muscle loss due to fibrotic or adipogenic replacement of myofibers is common in muscle diseases and muscle-resident fibro/adipogenic precursors (FAPs) are implicated in this process. While FAP-mediated muscle fibrosis is widely studied in muscle diseases, the role of FAPs in adipogenic muscle loss is not well understood. [...]
2019 - 10.1038/s41467-019-10438-z
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 2430
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11 p, 4.2 MB |
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
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Penas Pérez, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Maloof, M. E. (University of Miami Miller School of Medicine. Center for Therapeutic Innovation. Department of Psychiatry and Behavioral Sciences) ;
Stathias, V. (University of Miami Miller School of Medicine. Center for Therapeutic Innovation. Department of Psychiatry and Behavioral Sciences) ;
Long, J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Tan, S. K. (University of Miami Miller School of Medicine. Department of Psychiatry and Behavioral Sciences) ;
Mier, J. (University of Miami Miller School of Medicine. Department of Neurosurgery. Miami Project to Cure Paralysis) ;
Fang, Y. (The Rockefeller University. Laboratory of Development Neurobiology) ;
Valdes, C. (Florida International University. Computing and Information Sciences) ;
Rodriguez-Blanco, J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Chiang, C. M. (University of Texas Southwestern Medical Center. Simmons Comprehensive Cancer Center. Department of Biochemistry and Department of Pharmacology) ;
Robbins, D. J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Liebl, D. J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Lee, J. K. (University of Miami Miller School of Medicine. Department of Neurosurgery. Miami Project to Cure Paralysis) ;
Hatten, M. E. (The Rockefeller University. Laboratory of Development Neurobiology) ;
Clarke, J. (University of Nebraska. Department of Statistics) ;
Ayad, N. G. (University of Miami Miller School of Medicine. Department of Psychiatry and Behavioral Sciences. Center for Therapeutic Innovation. Sylvester Comprehensive Cancer Center. Miami Project to Cure Paralysis)
Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this process underlies many neurological diseases including ataxia and the most common pediatric brain tumor, medulloblastoma. [...]
2019 - 10.1038/s41467-019-10799-5
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3028
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16 p, 3.4 MB |
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
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Salpietro, Vincenzo (Department of Neurosciences. Rehabilitation. Ophthalmology. Genetics. Maternal and Child Health. University of Genoa) ;
Dixon, Christine L. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Guo, Hui (Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics. School of Life Sciences. Central South University) ;
Bello, Oscar D. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Vandrovcova, Jana (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Efthymiou, Stephanie (University College London) ;
Maroofian, Reza (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Heimer, Gali (Pediatric Neurology Unit. Safra Children's Hospital. Sheba Medical Center and Sackler Faculty of Medicine. Tel Aviv University) ;
Burglen, Lydie (Centre de Référence des Malformations et Maladies Congénitales du Cervelet. Département de Génétique et Embryologie Médicale. APHP. Hôpital Trousseau) ;
Valence, Stephanie (Centre de Référence des Malformations et Maladies Congénitales du Cervelet. Service de Neurologie Pédiatrique. APHP. Hôpital Trousseau) ;
Torti, Erin (GeneDx) ;
Hacke, Moritz (Biochemistry Center. Heidelberg University) ;
Rankin, Julia (Royal Devon and Exeter NHS Foundation Trust) ;
Tariq, Huma (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Colin, Estelle (MitoLab. UMR CNRS 6015-INSERM U1083. MitoVasc Institute. Angers University) ;
Procaccio, Vincent (MitoLab. UMR CNRS 6015-INSERM U1083. MitoVasc Institute. Angers University) ;
Striano, Pasquale (Department of Neurosciences. Rehabilitation. Ophthalmology. Genetics. Maternal and Child Health. University of Genoa) ;
Mankad, Kshitij (Great Ormond Street Hospital for Children (Londres)) ;
Lieb, Andreas (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Chen, Sharon (Division of Medical Genetics. Northwell Health/Hofstra University SOM) ;
Pisani, Laura (Division of Medical Genetics. Northwell Health/Hofstra University SOM) ;
Bettencourt, Conceição (UCL Institute of Neurology (Regne Unit)) ;
Männikkö, Roope (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Manole, Andreea (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Brusco, Alfredo (Department of Medical Sciences. Medical Genetics Unit. University of Torino) ;
Grosso, Enrico (Department of Medical Sciences. Medical Genetics Unit. University of Torino) ;
Ferrero, Giovanni Battista (Department of Public Health and Pediatrics. University of Torino) ;
Armstrong, Judith (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Gueden, Sophie (Unit of Neuropediatrics. University Hospital) ;
Bar-Yosef, Omer (Pediatric Neurology Unit. Safra Children's Hospital. Sheba Medical Center and Sackler Faculty of Medicine. Tel Aviv University) ;
Tzadok, Michal (Pediatric Neurology Unit. Safra Children's Hospital. Sheba Medical Center and Sackler Faculty of Medicine. Tel Aviv University) ;
Monaghan, Kristin G. (GeneDx) ;
Santiago-Sim, Teresa (GeneDx) ;
Person, Richard E. (GeneDx) ;
Cho, Megan T. (GeneDx) ;
Willaert, Rebecca (GeneDx) ;
Yoo, Kristin (Department of Biomedical Sciences. Seoul National University) ;
Chae, Jong-Hee (Department of Pediatrics. Seoul National University) ;
Quan, Yingting (Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics. School of Life Sciences. Central South University) ;
Wu, Huidan (Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics. School of Life Sciences. Central South University) ;
Wang, Tianyun (Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics. School of Life Sciences. Central South University) ;
Bernier, Raphael A. (Department of Psychiatry. University of Washington) ;
Xia, Kun (Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics. School of Life Sciences. Central South University) ;
Blesson, Alyssa (Center for Autism and Related Disorders. Kennedy Krieger Institute) ;
Jain, Mahim (Center for Autism and Related Disorders. Kennedy Krieger Institute) ;
Motazacker, Mohammad M. (Department of Clinical Genetics. University of Amsterdam) ;
Jaeger, Bregje (Department of Pediatric Neurology. Amsterdam UMC) ;
Schneider, Amy L. (Epilepsy Research Centre. Department of Medicine. University of Melbourne. Austin Health) ;
Boysen, Katja (Epilepsy Research Centre. Department of Medicine. University of Melbourne. Austin Health) ;
Muir, Alison M. (Department of Pediatrics. University of Washington) ;
Myers, Candance T. (Department of Pediatrics. Division of Genetic Medicine. University of Washington) ;
Gavrilova, Ralitza H. (Department of Clinical Genomics. Mayo Clinic) ;
Gunderson, Lauren (Department of Clinical Genomics. Mayo Clinic) ;
Schultz-Rogers, Laura (Department of Clinical Genomics. Mayo Clinic) ;
Klee, Eric W. (Department of Clinical Genomics. Mayo Clinic) ;
Dyment, David (Children's Hospital of Eastern Ontario Research Institute. University of Ottawa) ;
Osmond, Matthew (Genome Québec Innovation Center) ;
Parellada, Mara (Hospital General Universitario Gregorio Marañón) ;
Llorente, Cloe (Hospital General Universitario Gregorio Marañón) ;
González-Peñas, Javier (Hospital General Universitario Gregorio Marañón) ;
Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica) ;
Van Haeringen, Arie (Department of Clinical Genetics. Leiden University Medical Center) ;
Ruivenkamp, Claudia (Department of Clinical Genetics. Leiden University Medical Center) ;
Nava, Caroline (Department of Genetics. Assistance Publique - Hôpitaux de Paris. University Hôpital Pitié-Salpêtrière) ;
Heron, Delphine (Department of Genetics. Assistance Publique - Hôpitaux de Paris. University Hôpital Pitié-Salpêtrière) ;
Nardello, Rosaria (Department of Health Promotion,Mother and Child Care. Internal Medicine and Medical Specialities "G. D'Alessandro". University of Palermo) ;
Iacomino, Michele (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Minetti, Carlo (Department of Neurosciences. Rehabilitation. Ophthalmology. Genetics. Maternal and Child Health. University of Genoa) ;
Skabar, Aldo (Institute for Maternal and Child Health. IRCCS "Burlo Garofolo". University of Trieste) ;
Fabretto, Antonella (Institute for Maternal and Child Health. IRCCS "Burlo Garofolo". University of Trieste) ;
Hanna, Michael (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Bugiardini, Enrico (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Hostettler, Isabel Charlotte (UCL Queen Square Institute of Neurology (Regne Unit)) ;
O'Callaghan, Benjamin (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Khan, Alaa (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Cortese, Andrea (UCL Queen Square Institute of Neurology (Regne Unit)) ;
O'Connor, Emer (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Yau, Wai Y. (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Bourinaris, Thomas (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Kaiyrzhanov, Rauan (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Chelban, Viorica (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Madej, Monika (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Diana, Maria C. (Pediatric Neurology and Muscular Diseases Unit. IRCCS Istituto "Giannina Gaslini") ;
Vari, Maria S. (Pediatric Neurology and Muscular Diseases Unit. IRCCS Istituto "Giannina Gaslini") ;
Pedemonte, Marina (Pediatric Neurology and Muscular Diseases Unit. IRCCS Istituto "Giannina Gaslini") ;
Bruno, Claudio (Pediatric Neurology and Muscular Diseases Unit. IRCCS Istituto "Giannina Gaslini") ;
Balagura, Ganna (University of Genoa. Department of Neurosciences) ;
Scala, Marcello (University of Genoa. Department of Neurosciences) ;
Fiorillo, Chiara (University of Genoa. Department of Neurosciences) ;
Nobili, Lino (University of Genoa. Department of Neurosciences) ;
Malintan, Nancy T. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Zanetti, Maria N. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Krishnakumar, Shyam S. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Lignani, Gabriele (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Jepson, James E. C. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Broda, Paolo (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Baldassari, Simona (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Rossi, Pia (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Fruscione, Floriana (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Madia, Francesca (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Traverso, Monica (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
De-Marco, Patrizia (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Pérez-Dueñas, Belén (Hospital Universitari Vall d'Hebron) ;
Munell Casadesus, Francina (Hospital Universitari Vall d'Hebron) ;
Kriouile, Yamna (Children's Hospital of Rabat. University of Rabat) ;
El-Khorassani, Mohamed (Children's Hospital of Rabat. University of Rabat) ;
Karashova, Blagovesta (Department of Paediatrics. Medical University of Sofia) ;
Avdjieva, Daniela (Department of Paediatrics. Medical University of Sofia) ;
Kathom, Hadil (Department of Paediatrics. Medical University of Sofia) ;
Tincheva, Radka (Department of Paediatrics. Medical University of Sofia) ;
Van-Maldergem, Lionel (Centre of Human Genetics. University Hospital Liege) ;
Nachbauer, Wolfgang (Department of Neurology. Medical University Innsbruck) ;
Boesch, Sylvia (Department of Neurology. Medical University Innsbruck) ;
Gagliano, Antonella (Ospedale Pediatrico "A. Cao". Department of Biomedical Sciences. University of Cagliari) ;
Amadori, Elisabetta (Child and Adolescent Neuropsychiatry. University of Campania "Luigi Vanvitelli") ;
Goraya, Jatinder S. (Division of Paediatric Neurology. Dayanand Medical College & Hospital) ;
Sultan, Tipu (Department of Paediatric Neurology. Children's Hospital of Lahore) ;
Kirmani, Salman (Department of Medical Genetics. Aga Khan University Hospital. Karachi) ;
Ibrahim, Shahnaz (Department of Paediatric Neurology. Aga Khan University Hospital. Karachi) ;
Jan, Farida (Department of Paediatric Neurology. Aga Khan University Hospital. Karachi) ;
Mine, Jun (Department of Pediatrics. Shimane University School of Medicine) ;
Banu, Selina (Institute of Child Health and Shishu Shastho Foundation Hospital) ;
Veggiotti, Pierangelo (Vittore Buzzi Children's Hospital) ;
Zuccotti, Gian V. (Vittore Buzzi Children's Hospital) ;
Ferrari, Michel D.. (Leiden University Medical Center) ;
Van Den Maagdenberg, Arn M. J. (Leiden University Medical Center) ;
Verrotti, Alberto (Paediatric Department. San Salvatore Hospital. University of L'Aquila) ;
Marseglia, Gian Luigi (Department of Pediatrics. University of Pavia. IRCCS Policlinico "San Matteo") ;
Savasta, Salvatore (Department of Pediatrics. University of Pavia. IRCCS Policlinico "San Matteo") ;
Soler, Miguel A. (Computational Modelling of Nanoscale and Biophysical systems Laboratory. Italian Institute of Technology) ;
Scuderi, Carmela (Laboratorio di Neuropatologia Clinica. U.O.S. Malattie. Neuromuscolari Associazione OASI Maria SS. ONLUS - IRCCS) ;
Borgione, Eugenia (Laboratorio di Neuropatologia Clinica. U.O.S. Malattie. Neuromuscolari Associazione OASI Maria SS. ONLUS - IRCCS) ;
Chimenz, Roberto (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Gitto, Eloisa (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Dipasquale, Valeria (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Sallemi, Alessia (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Fusco, Monica (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Cuppari, Caterina (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Cutrupi, Maria C. (Department of Pediatrics. University Hospital "Gaetano Martino". University of Messina) ;
Ruggieri, Martino (Department of Clinical and Experimental Medicine. Section of Pediatrics and Child Neuropsychiatry. University of Catania) ;
Cama, Armando (Department of Neurosurgery. IRCCS Istituto Giannina Gaslini) ;
Capra, Valeria (Department of Neurosurgery. IRCCS Istituto Giannina Gaslini) ;
Mencacci, Niccolò Emanuele (Department of Neurology. Northwestern University Feinberg School of Medicine) ;
Boles, Richard (Courtagen Life Sciences) ;
Gupta, Neerja (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Kabra, Madhulika (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Papacostas, Savvas (The Cyprus Institute of Neurology and Genetics) ;
Zamba-Papanicolaou, Eleni (The Cyprus Institute of Neurology and Genetics) ;
Dardiotis, Efthimios (General University Hospital of Larissa (Grècia)) ;
Maqbool, Shazia (Department of Developmental and Behavioral Pediatrics. Children Hospital Complex and Institute of Child Health) ;
Rana, Nuzhat (Department of Pediatric Neurology. Children Hospital Complex and Institute of Child Health) ;
Atawneh, Osama (Hilal Pediatric Hospital Hebron. Hebron. West Bank) ;
Lim, Shen Y. (Department of Biomedical Science. Faculty of Medicine. University of Malaysia) ;
Shaikh, Mohmad Farooq (Jeffrey Cheah School of Medicine and Health Sciences. Monash University Malaysia) ;
Koutsis, George (Neurogenetics Unit. Neurology Department. Eginition Hospital. National and Kapodistrian University) ;
Breza, Marianthi (Neurogenetics Unit. Neurology Department. Eginition Hospital. National and Kapodistrian University) ;
Coviello, Domenico (Laboratorio di Genetica Umana. IRCCS Istituto Giannina Gaslini) ;
Dauvilliers, Yves (University Hospital of Montpellier (França)) ;
AlKhawaja, Issam (Albashir University Hospital) ;
AlKhawaja, Mariam (Prince Hamzah Hospital. Ministry of Health) ;
Al-Mutairi, Fuad (King Saud University) ;
Stojkovic, Tanya (Institute of Myology. Hôpital La Pitié Salpêtrière) ;
Ferrucci, Veronica (CEINGE. Biotecnologie Avanzate S.c.a.rl.) ;
Zollo, Massimo (CEINGE. Biotecnologie Avanzate S.c.a.rl.) ;
Alkuraya, Fowzan S (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ;
Kinali, Maria (The Portland Hospital) ;
Sherifa, Hamed (Assiut University Hospital) ;
Benrhouma, Hanene (Research Unit UR12 SP24. Department of Child and Adolescent Neurology. National Institute Mongi Ben Hmida of Neurology) ;
Turki, Ilhem B. Y. (Research Unit UR12 SP24. Department of Child and Adolescent Neurology. National Institute Mongi Ben Hmida of Neurology) ;
Tazir, Meriem (Laboratoire de Recherche en Neurosciences. Service de Neurologie) ;
Obeid, Makram (Department of Anatomy. Cell Biology and Physiology. American University of Beirut Medical Center) ;
Bakhtadze, Sophia (Department of Child Neurology. Tbilisi State Medical University) ;
Saadi, Marianthi W. (Baghdad College of Medicine. Children Welfare Teaching Hospital) ;
Zaki, Maha (Human Genetics and Genome Research Division. National Research Centre) ;
Triki, Chahnez C. (Child Neurology Department. Hedi Chaker hospital- Sfax Tunisia) ;
Benfenati, Fabio (Istituto Italiano di Tecnologia) ;
Gustincich, Stefano (Istituto Italiano di Tecnologia) ;
Kara, Majdi (Paediatric Neurology Unit. Department of Pediatrics. University of Tripoli) ;
Belcastro, Vincenzo (Neurology Unit. S. Anna Hospital) ;
Specchio, Nicola (Ospedale Pediatrico Bambino Gesù (Roma, Itàlia)) ;
Capovilla, Giuseppe (Child Neuropsychiatry Department. Epilepsy Center. C. Poma Hospital) ;
Karimiani, Ehsan G. (Genetics Research Centre. Molecular and Clinical Sciences Institute. St George's. University of London. Cranmer Terrace) ;
Salih, Ahmed M. (Medical University of Duhok) ;
Okubadejo, Njideka (College of Medicine. University of Lagos (CMUL) & Lagos University Teaching Hospital) ;
Ojo, Oluwadamilola (College of Medicine. University of Lagos (CMUL) & Lagos University Teaching Hospital) ;
Oshinaike, Olajumoke O. (College of Medicine. University of Lagos (CMUL) & Lagos University Teaching Hospital) ;
Oguntunde, Olapeju (College of Medicine. University of Lagos (CMUL) & Lagos University Teaching Hospital) ;
Wahab, Kolawole Wasiu (University of Ilorin Teaching Hospital (UITH)) ;
Bello, Abiodun H. (University of Ilorin Teaching Hospital (UITH)) ;
Abubakar, Sanni (Ahmadu Bello University) ;
Obiabo, Yahaya (Delta State University Teaching Hospital) ;
Nwazor, Ernest (Federal Medical Centre) ;
Ekenze, Oluchi (University of Nigeria Teaching Hospital) ;
Williams, Uduak (University of Calabar Teaching Hospital) ;
Iyagba, Alagoma (University of Port Harcourt Teaching Hospital) ;
Taiwo, Lolade (Babcock University. Ilishan. Remo & Federal Medical Centre) ;
Komolafe, Morenikeji (Obafemi Awolowo University Teaching Hospital (OAUTH)) ;
Senkevich, Konstantin (Pavlov First Saint Petersburg State Medical University) ;
Shashkin, Chingiz (Kazakh National State University) ;
Zharkynbekova, Nazira (Shymkent Medical Academy) ;
Koneyev, Kairgali (Kazakh National State University) ;
Manizha, Ganieva (Avicenna Tajik State Medical University) ;
Isrofilov, Maksud (Avicenna Tajik State Medical University) ;
Guliyeva, Ulviyya (Mediclub clinic) ;
Salayev, Kamran (Azerbaijan State Medical University) ;
Khachatryan, Samson G. ("Somnus" Neurology Clinic Sleep and Movement Disorders Center) ;
Rossi, Salvatore (Department of Neurology. Università Cattolica del Sacro Cuore) ;
Silvestri, Gabriella (Department of Neurology. Università Cattolica del Sacro Cuore) ;
Haridy, Nourelhoda A. (Department of Neurology and Psychiatry. Assuit University Hospital) ;
Ramenghi, Luca A. (Neonatal Intensive Care Unit. Istituto Giannina Gaslini) ;
Xiromerisiou, Georgia (Department of Neurology. Medical School. University of Thessaly) ;
David, Emanuele (Radiology Unit. Papardo Hospital. Viale Ferdinando Stagno d'Alcontres. Contrada Papardo) ;
Aguennouz, M'hammed (Unit of Neurology and Neuromuscular Diseases. Department of Clinical and Experimental Medicine. University of Messina) ;
Fidani, Lliana (Department of Biology. Medical School. Aristotle University) ;
Spanaki, Cleanthe (Department of Neurology. Medical School. University of Crete) ;
Tucci, Arianna (William Harvey Research Institute. The NIHR Biomedical Research Centre at Barts. Queen Mary University London) ;
Raspall-Chaure, Miquel (Hospital Universitari Vall d'Hebron) ;
Chez, Michael (Neuroscience Medical Group. 1625 Stockton Boulevard. Suite 104) ;
Tsai, Anne (Department of Genetics and Inherited Metabolic diseases. Children's Hospital Colorado) ;
Fassi, Emily (Department of Pediatrics. Washington University School of Medicine) ;
Shinawi, Marwan (Department of Pediatrics. Washington University School of Medicine) ;
Constantino, John N. (William Greenleaf Eliot Division of Child & Adolescent Psychiatry. Department of Psychiatry. Washington University School of Medicine) ;
De Zorzi, Rita (Department of Chemical and Pharmaceutical Sciences. University of Trieste) ;
Fortuna, Sara (Department of Chemical and Pharmaceutical Sciences. University of Trieste) ;
Kok, Fernando (Mendelics Genomic Analysis) ;
Keren, Boris (Department of Genetics. Assistance Publique - Hôpitaux de Paris. University Hôpital Pitié-Salpêtrière) ;
Bonneau, Dominique (MitoLab. UMR CNRS 6015-INSERM U1083. MitoVasc Institute. Angers University) ;
Choi, Murim (Department of Biomedical Sciences. Seoul National University) ;
Benzeev, Bruria (Pediatric Neurology Unit. Safra Children's Hospital. Sheba Medical Center and Sackler Faculty of Medicine. Tel Aviv University) ;
Zara, Federico (Laboratory of Neurogenetics and Neuroscience. IRCCS Istituto "Giannina Gaslini") ;
Mefford, Heather C. (Department of Pediatrics. University of Washington) ;
Scheffer, Ingrid E. (Epilepsy Research Centre. Department of Medicine. University of Melbourne. Austin Health) ;
Clayton-Smith, Jill (Division of Evolution and Genomic Sciences. School of Biological Sciences. University of Manchester) ;
Macaya Ruiz, Alfons (Hospital Universitari Vall d'Hebron) ;
Rothman, James E. (Department of Cell Biology. Yale University School of Medicine) ;
Eichler, Evan E (Howard Hughes Medical Institute. University of Washington) ;
Kullmann, Dimitri M. (Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology) ;
Houlden, Henry (UCL Queen Square Institute of Neurology (Regne Unit)) ;
Universitat Autònoma de Barcelona
AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca-impermeable, with a linear relationship between current and trans-membrane voltage. [...]
2019 - 10.1038/s41467-019-10910-w
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3094
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7.
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14 p, 2.2 MB |
Adaptive responses of animals to climate change are most likely insufficient
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Radchuk, V. (Leibniz Institute for Zoo and Wildlife Research) ;
Reed, T. (University College Cork. School of Biological. Earth and Environmental Sciences) ;
Teplitsky, C. (Université de Montpellier) ;
van de Pol, M. (Netherlands Institute of Ecology. Department of Animal Ecology) ;
Charmantier, A. (Université de Montpellier) ;
Hassall, C. (University of Leeds. School of Biology. Faculty of Biological Sciences) ;
Adamík, P. (Palacký University. Department of Zoology) ;
Adriaensen, F. (University of Antwerp. Evolutionary Ecology Group) ;
Ahola, M. P. (Swedish Museum of Natural History) ;
Arcese, P. (Department of Forest and Conservation Sciences) ;
Miguel Avilés, J. (Experimental Station of Arid Zones (EEZA-CSIC). Department of Functional and Evolutionary Ecology.) ;
Balbontin, J. (Universidad de Sevilla) ;
Berg, K. S. (University of Texas Rio Grande Valley. Department of Biological Sciences.) ;
Borras, Antoni (Museu de Ciències Naturals de Barcelona) ;
Burthe, S. (Centre for Ecology and Hydrology. Bush Estate) ;
Clobert, J. (University Paul Sabatier) ;
Dehnhard, N. (University of Antwerp. Behavioural Ecology and Ecophysiology Group) ;
de Lope, F. (Universidad de Extremadura) ;
Dhondt, A. A. (Cornell University) ;
Dingemanse, N. J. (Ludwig-Maximilians University of Munich. Department of Biology) ;
Doi, H. (University of Hyogo. Graduate School of Simulation Studies) ;
Eeva, T. (University of Turku. Department of Biology) ;
Fickel, J. (Potsdam University. Institute for Biochemistry and Biology) ;
Filella, Iolanda (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Fossøy, F. (Norwegian University of Science and Technology) ;
Goodenough, A. E. (University of Gloucestershire. School of Natural and Social Sciences) ;
Hall, Stephen (Estonian University of Life Sciences) ;
Hansson, B. (Lund University. Department of Biology) ;
Harris, M. (Centre for Ecology and Hydrology. Bush Estate) ;
Hasselquist, D. (Lund University. Department of Biology) ;
Hickler, Thomas (Senckenberg Biodiversity and Climate Research Center (BiK-F)) ;
Joshi, J. (Institute for Landscape and Open Space.) ;
Kharouba, H. (University of Ottawa. Department of Biology) ;
Martínez, J. G. (Universidad de Granada. Departamento de Zoología) ;
Mihoub, J. B. (Sorbonne Université. Muséum National d'Histoire Naturelle) ;
Mills, J. A. (3 Miromiro Drive) ;
Molina-Morales, M. (Universidad de Extremadura) ;
Moksnes, A. (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Ozgul, A. (University of Zurich. Department of Evolutionary Biology and Environmental Studies) ;
Parejo, D. (Universidad of Extremadura) ;
Pilard, P. (LPO Mission Rapaces) ;
Poisbleau, M. (University of Antwerp. Behavioural Ecology and Ecophysiology Group) ;
Rousset, F. (Université de Montpellier) ;
Rödel, M. O. (Leibniz Institute for Evolution and Biodiversity Science) ;
Scott, D. (University of Georgia. Savannah River Ecology Laboratory) ;
Senar, Joan Carles (Museu de Ciències Naturals de Barcelona) ;
Stefanescu, C. (Natural History Museum of Granollers) ;
Stokke, B. G. (Norwegian Institute for Nature Research) ;
Kusano, T. (Tokyo Metropolitan University. Department of Biological Sciences.) ;
Tarka, M. (Lund University. Department of Biology) ;
Tarwater, C. E. (University of Wyoming. Department of Zoology and Physiology) ;
Thonicke, Kirsten (Potsdam Institute for Climate Impact Research (PIK)) ;
Thorley, J. (University of Cambridge. Department of Zoology) ;
Wilting, Andreas (Leibniz Institute for Zoo and Wildlife Research (IZW)) ;
Tryjanowski, P. (Poznan University of Life Sciences. Institute of Zoology) ;
Merilä, J. (University of Helsinki. Ecological Genetics Research Unit) ;
Sheldon, B. C. (University of Oxford. Edward Grey Institute) ;
Pape Møller, A. (Université Paris-Sud. Ecologie Systématique Evolution) ;
Matthysen, Erik (University of Antwerp. Evolutionary Ecology Group) ;
Janzen, F. (Iowa State University) ;
Dobson, F. S. (Auburn University. Department of Biological Sciences) ;
Visser, M. E. (Netherlands Institute of Ecology. Department of Animal Ecology) ;
Beissinger, S. R. (University of California. Department of Environmental Science. Policy and Management and Museum of Vertebrate Zoology) ;
Courtiol, A. (Leibniz Institute for Zoo and Wildlife Research) ;
Kramer-Schadt, S. (Technische Universität Berlin. Department of Ecology)
Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i. e. [...]
2019 - 10.1038/s41467-019-10924-4
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3109
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8.
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19 p, 2.5 MB |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
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Argemi, Josepmaria (Universidad de Navarra) ;
Latasa, M. U. (Hepatology Program. Center for Applied Medical Research (CIMA). University of Navarra) ;
Atkinson, Stephen R (Imperial College London) ;
Blokhin, I. O. (CUniversity of Miami Miller School of Medicine) ;
Massey, V. (University of North Carolina at Chapel Hill) ;
Gue, J. P. (University of Pittsburgh Medical Center) ;
Cabezas González, Joaquín (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Lozano, Juan José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Van Booven, D. (University of Miami) ;
Bell, Aaron (University of Pittsburgh School of Medicine) ;
Cao, S. (Mayo Clinic) ;
Vernetti, L. A. (University of Pittsburgh) ;
Arab, J. P. (Pontificia Universidad Católica de Chile) ;
Ventura-Cots, Meritxell (University of Pittsburgh Medical Center) ;
Edmunds, L. R. (University of Pittsburgh) ;
Fondevilla, C. (Hospital Clínic i Provincial de Barcelona) ;
Stärkel, P. (Université Catholique de Louvain) ;
Dubuquoy, L. (University of Lille) ;
Louvet, Alexandre (University of Lille) ;
Òdena Garcia, Gemma (University of North Carolina at Chapel Hill) ;
Gomez, J. L. (University of Pittsburgh School of Medicine) ;
Aragon, T. (Universidad de Navarra) ;
Altamirano, José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Caballería, J (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Jurczak, M. J. (University of Pittsburgh) ;
Taylor, D. L. (University of Pittsburgh) ;
Berasain, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Wahlestedt, C. (University of Miami Miller School of Medicine) ;
Monga, S. P. (University of Pittsburgh School of Medicine) ;
Morgan, M. Y. (University College London) ;
Sancho-Bru, P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mathurin, Philippe (University of Lille) ;
Furuya, S. (Texas A&M University) ;
Lackner, C. (Medical University of Graz) ;
Rusyn, I. (Texas A&M University) ;
Shah, V. H. (Mayo Clinic) ;
Thursz, M. R. (Imperial College London) ;
Mann, J. (Newcastle University) ;
Avila, Matias A (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bataller, Ramon (University of North Carolina at Chapel Hill) ;
Universitat Autònoma de Barcelona
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. [...]
2019 - 10.1038/s41467-019-11004-3
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3126
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9.
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15 p, 4.6 MB |
Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab
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Serra-Peinado, Carla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luque-Ballesteros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallego-Rodriguez, Jenny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín Castillo, Mario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribera, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Raventós, Berta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Willekens, Rein (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badía, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The identification of exclusive markers to target HIV-reservoir cells will represent a significant advance in the search for therapies to cure HIV. Here, we identify the B lymphocyte antigen CD20 as a marker for HIV-infected cells in vitro and in vivo. [...]
2019 - 10.1038/s41467-019-11556-4
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3705
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10.
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14 p, 1.8 MB |
Evolutionary and functional impact of common polymorphic inversions in the human genome
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Giner-Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villatoro, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lerga Jaso, Jon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gayà Vidal, Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Oliva Pavia, Meritxell (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pantano, Lorena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bitarello, Bárbara D. (Max-Planck-Institut für Evolutionäre Anthropologie) ;
Izquierdo Fontanills, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Noguera, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Olalde, Iñigo (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Delprat Obeaga, Alejandra (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Blancher, Antoine (Centre de Physiopathologie Toulouse-Purpan) ;
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Esko, Tõnu (Estonian Genome Center) ;
O'Reilly, Paul F. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Andrés, Aida M. (Max-Planck-Institut für Evolutionäre Anthropologie) ;
Ferretti, Luca (University of Oxford. Big Data Institute) ;
Puig Font, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. [...]
2019 - 10.1038/s41467-019-12173-x
Nature communications, Vol. 10 (2019) , art. 4222
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11.
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16 p, 2.5 MB |
Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
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Cantero, Jon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Serra-Peinado, Carla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosero, D. A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luque-Ballesteros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castellvi, Josep. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sanhueza, T. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lloveras, B. (Parc de Salut MAR de Barcelona) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sole-Sedeno, Josep-Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tarrats, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lecumberri, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mañalich-Barrachina, L. (Hospital Universitari Vall d'Hebron) ;
Centeno-Mediavilla, C. (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Genescà Ferrer, Meritxell. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
HIV viral reservoirs are established very early during infection. Resident memory T cells (T) are present in tissues such as the lower female genital tract, but the contribution of this subset of cells to the pathogenesis and persistence of HIV remains unclear. [...]
2019 - 10.1038/s41467-019-12732-2
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4739
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11 p, 871.5 KB |
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
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Powers, R. K. (Department of Pharmacology. University of Colorado Anschutz Medical Campus) ;
Culp-Hill, R. (Department of Biochemistry and Molecular Genetics. University of Colorado Anschutz Medical Campus) ;
Ludwig, M. P. (Department of Pharmacology. University of Colorado Anschutz Medical Campus) ;
Smith, K. P. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Waugh, K. A. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Minter, R. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Tuttle, K. D. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Lewis, H. C. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Rachubinski, A. L. (Department of Pediatrics. University of Colorado Anschutz Medical Campus) ;
Granrath, R. E. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Wilkerson, R. B. (Department of Biochemistry and Molecular Genetics. University of Colorado Anschutz Medical Campus) ;
Kahn, D. E. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ;
Joshi, M. (Functional Genomics Facility. University of Colorado Anschutz Medical Campus) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
D'Alessandro, A. (Department of Biochemistry and Molecular Genetics. University of Colorado Anschutz Medical Campus) ;
Costello, J. C. (Department of Pharmacology. University of Colorado Anschutz Medical Campus) ;
Sullivan, K. D. (Functional Genomics Facility. University of Colorado Anschutz Medical Campus) ;
Espinosa, J. M. (Department of Molecular. Cellular and Developmental Biology. University of Colorado Boulder) ;
Universitat Autònoma de Barcelona
Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of plasma and cerebrospinal fluid, showing in independent cohorts that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively. [...]
2019 - 10.1038/s41467-019-12739-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4766
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13 p, 1.4 MB |
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
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Lyons, Paul A. (Uniit)) ;
Peters, James E. (Health Data Research UK) ;
Alberici, Federico (University of Milano) ;
Liley, James (Cambridge Institute of Public Health) ;
Coulson, Richard M. R. (University of Cambridge School of Clinical Medicine. University of Cambridge) ;
Astle, William (NHS Blood and Transplant) ;
Baldini, Chiara (University of Pisa) ;
Bonatti, Francesco (University Hospital of Parma) ;
Cid, María Cinta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Elding, Heather (Wellcome Trust Sanger Institute (Regne Unit)) ;
Emmi, Giacomo (University of Firenze) ;
Epplen, Jörg (Ruhr University Bochum) ;
Guillevin, Loïc (Hôpital Cochin) ;
Jayne, David R. W. (University of Cambridge School of Clinical Medicine) ;
Jiang, Tao (University of Cambridge) ;
Gunnarsson, Iva (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Lamprecht, Peter (University of Lübeck) ;
Leslie, Stephen (Data Science. Murdoch Children's Research Institute) ;
Little, Mark A. (Tallaght Hospital) ;
Martorana, Davide (University Hospital of Parma) ;
Moosig, Frank (Rheumazentrum Schleswig-Holstein Mitte) ;
Neumann, Thomas (Department of Rheumatology. Immunology and Rehabilitation. Cantonal Hospital St. Gallen) ;
Ohlsson, Sophie (Department of Nephrology. Division of Clinical Sciences. Lund University) ;
Quickert, Stefan (Department of Internal Medicine 4 (Gastroenterology. Hepatology. and Infectious Diseases). Jena University Hospital) ;
Ramirez, Giuseppe A. (Unit of Immunology. Rheumatology. Allergy and Rare Diseases. Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
Rewerska, Barbara (Jagiellonian University Medical College) ;
Schett, George (Department of Internal Medicine 3. Rheumatology and Immunology. Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen) ;
Sinico, Renato A. (Università degli Studi di Milano-Bicocca) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Tesar, Vladimir (Charles University) ;
Vukcevic, Damjan (Murdoch Children's Research Institute) ;
Akil, Mohammed (Sheffield Royal Hallamshire Hospital) ;
Barratt, Jonathan (University of Leicester) ;
Basu, Neil (University of Glasgow) ;
Butterworth, Adam (University of Cambridge) ;
Bruce, Ian (The University of Manchester) ;
Clarkson, Michael (Cork University Hospital) ;
Conlon, Niall (St James' Hospital Dublin) ;
DasGupta, Bhaskar (Southend University Hospital) ;
Doulton, Timothy W. R. (EKent and Canterbury Hospital) ;
Espígol-Frigolé, Georgina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Flossmann, Oliver (Royal Berkshire Hospital NHS Trust) ;
Gabrielli, Armando (Ospedali Riuniti-Università) ;
Gasior, Jolanta (University Hospital. Department of allergy and immunology) ;
Gregorini, Gina (Nephrology Unit. Spedali Civili) ;
Guida, Giuseppe (ASL TO2 Birago di Vische Hospital) ;
Hernández Rodríguez, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hruskova, Zdenka (Charles University) ;
Hudson, Amy (Data Science. Murdoch Children's Research Institute) ;
Knight, Ann (Department of Medical Sciences. Uppsala University) ;
Lanyon, Peter (Nottingham University Hospitals NHS Trust (Regne Unit)) ;
Luqmani, Raashid (Nuffield Orthopaedic Centre) ;
Magliano, Malgorzata (Stoke Mandeville Hospital) ;
Manfredi, Angelo A. (Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
Marguerie, Christopher (South Warwickshire NHS Foundation Trust) ;
Maritati, Federica (University of Firenze) ;
Marvisi, Chiara (University of Firenze) ;
McHugh, Neil J. (Royal National Hospital for Rheumatic Disease) ;
Molloy, Eaminn (St Vincent's Hospital Dublin) ;
Motyer, Allan (University of Melbourne) ;
Mukhtyar, Chetan (Norfolk and Norwich University Hospital) ;
Padyukov, Leonid (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Pesci, Alberto (University of Milano Bicocca) ;
Prieto-Gonzalez, Sergio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ramentol-Sintas, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Reis, Petra (Friedrich Alexander University Erlangen-Nuremberg) ;
Roccatello, Dario (University of Torino) ;
Rovere-Querini, Patrizia (Jena University Hospital (Alemanya)) ;
Salvarani, Carlo (Università di Modena e Reggio Emilia) ;
Santarsia, Francesca (University Hospital of Parma) ;
Solans, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soranzo, Nicole (University of Cambridge) ;
Taylor, Jo (Dorset County Hospital) ;
Wessels, Julie (Royal Stoke University Hospital) ;
Zwerina, Jochen (Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen) ;
Terrier, Benjamin (Service de Médecine Interne. Hôpital Cochin) ;
Watts, Richard A. (Norwich Medical School. University of East Anglia) ;
Vaglio, Augusto (University of Firenze) ;
Holle, Julia U. (Rheumazentrum Schleswig-Holstein Mitte) ;
Wallace, Chris (Cambridge Institute of Public Health) ;
Smith, Kenneth G. C. (Jeffrey Cheah Biomedical Centre University of Cambridge) ;
Universitat Autònoma de Barcelona
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). [...]
2019 - 10.1038/s41467-019-12515-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 5120
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19 p, 6.1 MB |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis
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Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Romero-Giménez, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cuadros, Thais (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Sepúlveda, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peñuelas, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torra, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Galván, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ballabio, Andrea (Telethon Institute of Genetics and Medicine (TIGEM)) ;
Hasegawa, Takafumi (Department of Neurology. Tohoku University School of Medicin) ;
Bortolozzi, Analía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gelpi, Ellen (Institute of Neurology. Medical University of Vienna) ;
Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
2019 - 10.1038/s41467-019-08858-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 973
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