Published articles

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11 p, 854.8 KB Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations / Sardanyés, Josep (Universitat Pompeu Fabra) ; Simó, Carles (Universitat de Barcelona. Departament de Matemàtica Aplicada i Anàlisi) ; Martínez Barchino, Regina (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Solé, Ricard V. (Universitat Pompeu Fabra) ; Elena, Santiago F. (Universitat Politècnica de València. Instituto de Biología Molecular y Celular de Plantas)
The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. [...]
2014 - 10.1038/srep04625
Scientific reports, Vol. 4 (2014) , art. 4625  

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