Published articles

Published articles 1 records found  Search took 0.00 seconds. 
12 p, 1.4 MB Unraveling how the Gly526Ser mutation arrests prostaglandin formation from arachidonic acid catalyzed by cyclooxygenase-2 : A combined molecular dynamics and QM/MM study / Suñer Rubio, Adrián (Universitat Autònoma de Barcelona. Departament de Química) ; Cebrián Prats, Anna (Universitat Autònoma de Barcelona. Departament de Química) ; González Lafont, Àngels (Universitat Autònoma de Barcelona. Departament de Química) ; Lluch López, Josep Maria (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Cyclooxygenases (COXs) are the enzymes responsible for the biosynthesis of prostaglandins, eicosanoids that play a major role in many physiological processes. Particularly, prostaglandins are known to trigger inflammation, and COX-2, the enzyme isoform associated with this inflammatory response, catalyzes the cyclooxidation of arachidonic acid, leading to prostaglandin G2. [...]
2019 - 10.1039/c9ra08860a
RSC advances, Vol. 10, issue 2 (2019) , p. 986-997  

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