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1.
5 p, 653.8 KB Bone marrow clonogenic myeloid progenitors from NPM1-mutated AML patients do not harbor the NPM1 mutation : Implication for the cell-of-origin of NPM1+ AML / Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; González-silva, L. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ; López-Millán, Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Rodriguez-Sevilla, Juan Jose (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Baroni, Matteo Libero (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Anguita, Eduardo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Vives Polo, Susana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lapillonne, Hélène (Sorbonne Université. INSERM. Centre de recherche Saint-Antoine CRSA. AP-HP. Hôspital Armand Trousseau. Haematology Laboratory) ; Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
The cell-of-origin of NPM1- and FLT3-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML in diagnostic bone marrow (BM) from nine NPM1+/FLT3-ITD (+/−) AMLs. [...]
2020 - 10.3390/genes11010073
Genes, Vol. 11 Núm. 1 (2020) , p. 73  
Detailed record - Creative Commons
2.
25 p, 1.3 MB Understanding the relevance of DNA methylation changes in immune differentiation and disease / de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Immune cells are one of the most complex and diverse systems in the human organism. Such diversity implies an intricate network of different cell types and interactions that are dependently interconnected. [...]
2020 - 10.3390/genes11010110
Genes, Vol. 11 Núm. 1 (january 2020) , p. 110  
Detailed record - Creative Commons

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