Published articles

Published articles 1 records found  Search took 0.01 seconds. 
1.
9 p, 3.4 MB Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies / Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Jauset, Toni (Vall d'Hebron. Institut d'Oncologia) ; Díaz Riascos, Zamira V. (Centro de Investigación Biomédica en Red) ; Sánchez Chardi, Alejandro (Universitat de Barcelona. Departament de Biologia Evolutiva. Ecologia i Ciències Ambientals) ; Beaulieu, Marie Eve (Vall d'Hebron. Institut d'Oncologia) ; Seras-Franzoso, Joaquín (Vall d'Hebron Institut de Recerca) ; Sánchez García, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Baltà Foix, Ricardo. (Vall d'Hebron Institut de Recerca) ; Mancilla, Sandra (Centro de Investigación Biomédica en Red) ; Fernández, Yolanda (Centro de Investigación Biomédica en Red) ; Rinas, Ursula (Leibniz University of Hannover. Helmholtz Centre for Infection Research) ; Schwartz, Simó (Centro de Investigación Biomédica en Red) ; Soucek, Laura (Vall d'Hebron. Institut d'Oncologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Abasolo, Ibane (Centro de Investigación Biomédica en Red) ; Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44 tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. [...]
2019 - 10.1002/advs.201900849
Advanced science, Vol. 6, issue 18 (Sep. 2019) , art. 1900849  

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