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5 p, 765.8 KB |
Real-world evidence of brexucabtagene autoleucel for the treatment of relapsed or refractory mantle cell lymphoma
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Iacoboni, Gloria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rejeski, Kai (Department of Medicine III, University Hospital, LMU Munich, Munich, Germany) ;
Villacampa Javierre, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
van Doesum, Jaap A. (Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands) ;
Chiappella, Annalisa (Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milano, Milano, Italy) ;
Bonifazi, Francesca (IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli", Bologna, Italy) ;
López Corral, Lucia (Centro de Investigación del Cáncer-IBMCC, Salamanca, Spain) ;
van Aalderen, Michiel (Department of Hematology, Amsterdam University Medical Centers, Cancer Center Amsterdam, LYMMCARE (Lymphoma and Myeloma Center Amsterdam), Amsterdam, The Netherlands) ;
Kwon, Mi (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Martínez-Cibrian, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Bramanti, Stefania (Istituto Clinico Humanitas IRCCS, Rozzano, Italy) ;
Reguera-Ortega, Juan Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Camacho-Arteaga, Lina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Schmidt, Christian (Department of Medicine III, University Hospital, LMU Munich, Munich, Germany) ;
Marín-Niebla, Ana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Kersten, Marie José (Department of Hematology, Amsterdam University Medical Centers, Cancer Center Amsterdam, LYMMCARE (Lymphoma and Myeloma Center Amsterdam), Amsterdam, The Netherlands) ;
Martín García-Sancho, Alejandro (Instituto de Investigación Biomédica de Salamanca) ;
Zinzani, Pier Luigi (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università di Bologna, Bologna, Italy) ;
Corradini, Paolo (Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milano, Milano, Italy) ;
van Meerten, Tom (Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands) ;
Subklewe, Marion (Department of Medicine III, University Hospital, LMU Munich, Munich, Germany) ;
Barba, Pere (Universitat Autònoma de Barcelona. Departament de Medicina)
2022 -  10.1182/bloodadvances.2021006922
Blood advances, Vol. 6 (june 2022) , p. 3606-3610
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9 p, 1.0 MB |
Metformin for treatment of cytopenias in children and young adults with Fanconi anemia
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Pollard, Jessica A. (Department of Pediatrics, Harvard Medical School, Boston, MA) ;
Furutani, Elissa (Department of Pediatrics, Harvard Medical School, Boston, MA) ;
Liu, Shanshan (Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Harvard Medical School, Boston, MA) ;
Esrick, Erica (Department of Pediatrics, Harvard Medical School, Boston, MA) ;
Cohen, Laurie E. (Department of Endocrinology, and) ;
Bledsoe, Jacob (Department of Pathology, Boston Children's Hospital, Boston, MA) ;
Liu, Chih-Wei (Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC) ;
Lu, Kun (Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC) ;
Ramírez de Haro, Ma. José (Institut d'Investigació Biomèdica Sant Pau) ;
Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Malsch, Maggie (Clinical Research Operations Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA) ;
Kuniholm, Ashley (Clinical Research Operations Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA) ;
Galvin, Ashley (Clinical Research Operations Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA) ;
Armant, Myriam (Trans Laboratory, Boston Children's Hospital, Boston, MA) ;
Kim, Annette S. (Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA) ;
Ballotti, Kaitlyn (Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA) ;
Moreau, Lisa (Comprehensive Center for Fanconi Anemia, Dana-Farber Cancer Institute, Boston, MA) ;
Zhou, Yu (Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA) ;
Babushok, Daria (Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA) ;
Boulad, Farid (Pediatric Hematology-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY) ;
Carroll, Clint (Pediatric Hematology-Oncology, The Children's Hospital at TriStar Centennial, Nashville, TN) ;
Hartung, Helge (Pediatric Hematology-Oncology, Children's Hospital of Philadelphia, Philadelphia, PA) ;
Hont, Amy (Pediatric Hematology-Oncology, Children's National Medical Center, Washington, DC) ;
Nakano, Taizo (Pediatric Hematology-Oncology, Children's Hospital Colorado, Denver, CO) ;
Olson, Tim (Pediatric Hematology-Oncology, Children's Hospital of Philadelphia, Philadelphia, PA) ;
Sze, Sei-Gyung (Department of Pediatrics, Maine Medical Center, Tufts University School of Medicine, Portland, ME) ;
Thompson, Alexis A. (Pediatric Hematology-Oncology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL) ;
Wlodarski, Marcin W. (Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN) ;
Gu, Xuesong (Beth Israel Deaconess Medical Center Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA) ;
Libermann, Towia A. (Beth Israel Deaconess Medical Center Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA) ;
D'Andrea, Alan (Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA) ;
Grompe, Markus (Oregon Stem Cell Center, Department of Pediatrics, Papé Family Institute, Oregon Health and Science University, Portland, OR; and) ;
Weller, Edie (Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Harvard Medical School, Boston, MA) ;
Shimamura, Akiko (Department of Pediatrics, Harvard Medical School, Boston, MA)
Fanconi anemia (FA), a genetic DNA repair disorder characterized by marrow failure and cancer susceptibility. In FA mice, metformin improves blood counts and delays tumor development. We conducted a single institution study of metformin in nondiabetic patients with FA to determine feasibility and tolerability of metformin treatment and to assess for improvement in blood counts. [...]
2022 - 10.1182/bloodadvances.2021006490
Blood advances, Vol. 6 (june 2022) , p. 3803-3811
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