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17 p, 2.8 MB

Opposite effects of moderate and extreme Cx43 deficiency in conditional Cx43-deficient mice on angiotensin II-induced cardiac fibrosis / Valls de Lacalle, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Negre-Pujol, Corall (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Varona, Saray (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Valera Cañellas, Antoni (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Consegal, Marta (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Martínez-González, José (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Universitat Autònoma de Barcelona
Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43fl/fl and Cx43Cre-ER(T)/fl inducible knock-out (Cx43 content: 50%) mice treated with vehicle or 4-hydroxytamoxifen (4-OHT) to induce a Cre-ER(T)-mediated global deletion of the Cx43 floxed allele. [...]
2019 - DOI (Digital Object Identifier)

10.3390/cells8101299
Cells, Vol. 8 (2019) , p. 1-17

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