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14 p, 2.0 MB PH-dependent aggregation in intrinsically disordered proteins is determined by charge and lipophilicity / Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangiagalli, Marco (Department of Biotechnology and Biosciences, University of Milano-Bicocca) ; Santos-Suárez, Juan (Galicia Supercomputing Center (CESGA)) ; Brocca, Stefania (Department of Biotechnology and Biosciences, University of Milano-Bicocca) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Protein aggregation is associated with an increasing number of human disorders and premature aging. Moreover, it is a central concern in the manufacturing of recombinant proteins for biotechnological and therapeutic applications. [...]
2020 - 10.3390/cells9010145
Cells, Vol. 9 (2020)  
Detailed record - Public domain

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