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8 p, 888.7 KB Rupatadine Oral Solution Titration by Body Weight in Paediatric Patients Suffering from Allergic Rhinitis : A Population Pharmacokinetic Study / Santamaria, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Izquierdo, Iñaki (Biorhom SL Grupo Uriach) ; Valle, Marta (Institut d'Investigació Biomèdica Sant Pau)
Allergic rhinitis (AR) and chronic urticaria, both are treated in children with doses of second generation of antihistamines that have been mostly based on extrapolation of data obtained in adults. The objectives of this work were to develop a model to explain the pharmacokinetics (PK) of rupatadine, a second generation antihistamine, administered to children 2−11 years old and to calculate the non-compartmental PK parameters for two groups of age (2-5 and 6-11 years old) based on the individual Bayesian estimates from the selected model. [...]
2021 - 10.2147/CPAA.S312911
Clinical Pharmacology : Advances and Applications, Vol. 13 (june 2021) , p. 115-122  
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