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11 p, 519.1 KB 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers / Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ; Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich) ; Brendel, Matthias (Ludwig-Maximilians-University Munich) ; Rominger, Axel (Ludwig-Maximilians-University Munich) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau) ; Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE)) ; Traschütz, Andreas (Universitätsklinikum Bonn) ; Heneka, Michael T. (Universitätsklinikum Bonn) ; Struyfs, Hanne (University Hospital Antwerp (Bèlgica)) ; Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ; Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ; Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences) ; Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology) ; Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology) ; Ewers, Michael (Ludwig-Maximilians-University Munich) ; Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich) ; Universitat Autònoma de Barcelona
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). [...]
2016 - 10.15252/emmm.201506123
EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476  
Detailed record - Creative Commons

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