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14 p, 657.9 KB Cardiopoietic cell therapy for advanced ischaemic heart failure : results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial / Bartunek, Jozef (Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis OLV Hospital, Moorselbaan 164, Aalst, B-9300, Aalst, Belgium) ; Terzic, Andre (Mayo Clinic, Center for Regenerative Medicine, Department of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 550905, USA) ; Davison, Beth A. (Momentum Research, Inc, Durham, NC, USA) ; Filippatos, Gerasimos S. (University General Hospital Attikon (Haidari, Grècia)) ; Radovanovic, Slavica (University Hospital Center Bezanijska Kosa, Belgrade, Serbia) ; Beleslin, Branko (University of Belgrade. Cardiology Clinic) ; Merkely, Bela (Semmelweis University. Heart and Vascular Center) ; Musialek, Piotr (Jagiellonian University Department of Cardiac and Vascular Diseases, John Paul II Hospital, Krakow, Poland) ; Wojakowski, Wojciech (Third Division of Cardiology, Medical University of Silesia, Katowice, Poland) ; Andreka, Peter (Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest, Hungary) ; Horvath, Ivan G. (Heart Institute, University of Pécs, Pécs, Hungary) ; Katz, Amos (Department of Cardiology, Barzilai Medical Center, Israel Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel) ; Dolatabadi, Dariouch (Division of Cardiology, Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium) ; El Nakadi, Badih (Division of Cardiology, Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium) ; Arandjelovic, Aleksandra (Cardiology Department, Clinical Hospital Zvezdara, Belgrade, Serbia) ; Edes, Istvan (Department of Cardiology, University of Debrecen, Debrecen, Hungary) ; Seferovic, Petar M. (University of Belgrade School of Medicine, Belgrade University Medical Center, Belgrade, Serbia) ; Obradovic, Slobodan (Clinic of Emergency Medicine, Military Medical Academy, School of Medicine, University of Defense, Belgrade, Serbia) ; Vanderheyden, Marc (Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis OLV Hospital, Moorselbaan 164, Aalst, B-9300, Aalst, Belgium) ; Jagic, Nikola (Clinical Center Kragujevac, Kragujevac, Serbia) ; Petrov, Ivo (Department of Cardiology, Angiology, and Electrophysiology, City Clinic Heart and Vascular Institute, Sofia University, Sofia, Bulgaria) ; Atar, Shaul (Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel) ; Halabi, Majdi (Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel) ; Gelev, Valeri L. (Department of Cardiology, Angiology, and Electrophysiology, City Clinic Heart and Vascular Institute, Sofia University, Sofia, Bulgaria) ; Shochat, Michael K. (Heart Institute, Hillel Yaffe Medical Center, Hadera, Rappaport School of Medicine, Haifa, Israel, Technion) ; Kasprzak, Jaroslaw D. (Medical University of Lodz) ; Sanz-Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ; Heyndrickx, Guy R. (Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis OLV Hospital, Moorselbaan 164, Aalst, B-9300, Aalst, Belgium) ; Nyolczas, Noémi (Medical Centre, Hungarian Defense Forces, Budapest, Hungary) ; Legrand, Victor (Department of Cardiology, Centre Hospitalier Universitaire de Liège, Liège, Belgium) ; Guédès, Antoine (Department of Cardiology, Universite Catholique de Louvain, CHU UcL Namur, Yvoir, Belgium) ; Heyse, Alex (Department of Cardiology, AZ Glorieux, Ronse, Belgium) ; Moccetti, Tiziano (Cardiocentro Ticino, Lugano, Switzerland) ; Fernandez Aviles, Francesc (Hospital General Universitario Gregorio Marañón) ; Jimenez-Quevedo, Pilar (Hospital Clínico San Carlos (Madrid)) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hernandez-Garcia, Jose Maria (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ; Ribichini, Flavio (Department of Cardiology, University of Verona, Italy) ; Gruchala, Marcin (Department of Cardiology, Medical University of Gdansk, Gdansk, Poland) ; Waldman, Scott A. (Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA) ; Teerlink, John R. (School of Medicine, University of California San Francisco and Section of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA) ; Gersh, Bernard J. (Mayo Clinic, Center for Regenerative Medicine, Department of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 550905, USA) ; Povsic, Thomas J. (Duke Clinical Research Institute and Duke Medicine, Durham, NC, USA) ; Henry, Timothy D. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Metra, Marco (Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University and Spedali Civili, Brescia, Italy) ; Hajjar, Roger J. (Mount Sinai School of Medicine, New York, NY, USA) ; Tendera, Michal (Third Division of Cardiology, Medical University of Silesia, Katowice, Poland) ; Behfar, Atta (Mayo Clinic, Center for Regenerative Medicine, Department of Cardiovascular Diseases, 200 First Street SW, Rochester, Minnesota 550905, USA) ; Alexandre, Bertrand (Celyad, Mont Saint Guibert, Belgium) ; Seron, Aymeric (Celyad, Mont Saint Guibert, Belgium) ; Stough, Wendy Gattis (Departments of Clinical Research and Pharmacy Practice, Campbell University College of Pharmacy and Health Sciences, Cary, NC, USA) ; Sherman, Warren (Celyad, Mont Saint Guibert, Belgium) ; Cotter, Gad (Momentum Research, Inc, Durham, NC, USA) ; Wijns, William (The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway and Saolta University Healthcare Group, Galway, Ireland) ; Universitat Autònoma de Barcelona
Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. [...]
2016 - 10.1093/eurheartj/ehw543
European heart journal, Vol. 38 (december 2016) , p. 648-660  

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