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Articles publicats 2 registres trobats  La cerca s'ha fet en 0.01 segons. 
13 p, 3.9 MB Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome / Menendez, Javier A. (Institut d'Investigació Biomèdica (Girona)) ; Folguera-Blasco, Núria (Centre de Recerca Matemàtica) ; Cuyàs Navarro, Elisabet (Institut d'Investigació Biomèdica (Girona)) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. [...]
2016 - 10.18632/oncotarget.7867
Oncotarget, Vol. 7, issue 11 (March 2016) , p. 11959-11971  
18 p, 5.2 MB Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish / Aquilino, Carolina (Animal Health Research Center (CISA-INIA)) ; Granja, Aitor G. (Animal Health Research Center (CISA-INIA)) ; Castro, Rosario (Animal Health Research Center (CISA-INIA)) ; Wang, Tiehui (Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen) ; Abos, Beatriz (Animal Health Research Center (CISA-INIA)) ; Parra, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Secombes, Christopher J. (Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen) ; Tafalla, Carolina (Animal Health Research Center (CISA-INIA))
CK9 is a rainbow trout (Oncorhynchus mykiss) CC chemokine phylogenetically related to mammalian CCL25. Although CK9 is known to be transcriptionally regulated in response to inflammation particularly in mucosal tissues, its functionality has never been revealed. [...]
2016 - 10.18632/oncotarget.8163
Oncotarget, Vol. 7 (march 2016) , p. 17547-17564  

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