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13 p, 1.3 MB

Amerindian Ancestry Influences Genetic Susceptibility to Chronic Obstructive Pulmonary Disease / Díaz-Peña, Roberto (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Boekstegers, Felix (Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg) ; Silva, Rafael S. (Unidad Respiratorio, Centro de Diagnóstico Terapéutico, Hospital Regional de Talca) ; Jaime, Sergio (Unidad Respiratorio, Centro de Diagnóstico Terapéutico, Hospital Regional de Talca) ; Hosgood, H. Dean (Department of Epidemiology and Population Health, Albert Einstein College of Medicine) ; Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Agustí, Àlvar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lorenzo Bermejo, Justo (Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg) ; Olloquequi, Jordi (Universidad Autónoma de Chile. Instituto de Ciencias Biomédicas) ; Universitat Autònoma de Barcelona
The contribution of genetic ancestry on chronic obstructive pulmonary disease (COPD) predisposition remains unclear. To explore this relationship, we analyzed the associations between 754,159 single nucleotide polymorphisms (SNPs) and risk of COPD (n = 214 cases, 193 healthy controls) in Talca, Chile, considering the genetic ancestry and established risk factors. [...]
2020 - DOI (Digital Object Identifier)

10.3390/jpm10030093
Journal of personalized medicine, Vol. 10 (august 2020)

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