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4 p, 393.4 KB Copper(II) and the pathological H50Q α-synuclein mutant : environment meets genetics / Villar-Piqué, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ; Rossetti, Giulia (Jülich Forschungszentrum. Institut für Neurowissenschaften und Medizin) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Carloni, Paolo (Jülich Forschungszentrum. Institut für Neurowissenschaften und Medizin) ; Fernández, Claudio O. (Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario) ; Outeiro, Tiago Fleming (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Copper is one of the metals described to bind the Parkinson disease-related protein α-synuclein (aSyn), and to promote its aggregation. Although histidine at position 50 in the aSyn sequence is one of the most studied copper-anchoring sites, its precise role in copper binding and aSyn aggregation is still unclear. [...]
2017 - 10.1080/19420889.2016.1270484
Communicative & integrative Biology, Vol. 10, no. 1 (2017) , e127048  

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