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9 p, 2.9 MB Study and Preparation of Multifunctional Poly(L-Lysine)@Hyaluronic Acid Nanopolyplexes for the Effective Delivery of Tumor Suppressive MiR-34a into Triple-Negative Breast Cancer Cells / Djafari, Jamila (Nova University Lisbon. Chemistry Department) ; Fernández-Lodeiro, Javier (Proteomass Scientific Society) ; Santos, Hugo M. (Proteomass Scientific Society) ; Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rodriguez-Calado, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bértolo, Emilia (Canterbury Christ Church University) ; Capelo-Martínez, José Luis (Proteomass Scientific Society) ; Lodeiro, Carlos (Proteomass Scientific Society)
Non-viral gene delivery using exogenous microRNAs is a potential strategy for fighting cancers with poor prognosis and which lack specific therapies, such as triple-negative breast cancer (TNBC). Herein we report the synthesis of six nontoxic electrostatic polymeric nanocapsules (P1 to P6) for microRNA delivery in TNBC cells. [...]
2020 - 10.3390/ma13235309
Materials, Vol. 13, Issue 23 (December 2020) , art. 5309  
Detailed record - Creative Commons

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